World Alzheimer's Day is Tomorrow! Last Chance to
Double Your Impact.

We're down to one day left until World Alzheimer's Day
- when our World Alzheimer's Day 2X Match Challenge ends. We
only have until midnight tomorrow - September 21 - to
reach our goal. That's why

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we urgently need your support. Your gift today could be the one to
unlock these critically needed match funds that will advance research
for treatment breakthroughs, as well as help provide care and support
to the millions impacted by Alzheimer's disease or another dementia.

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MAKE A GIFT FOR WORLD ALZHEMER'S DAY

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POP QUIZ

Which of the following actions could lower your risk of
cognitive decline and possibly Alzheimer's and dementia?

Exercise

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Eating healthier foods

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Getting a good night's sleep

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All of the above

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Double Your Impact in the Fight with a Gift by Midnight
Tomorrow.

This World Alzheimer's Day, you have the chance to be part of
something big. Something global. Something that can change lives and
offer hope to generations to come. Thanks to our generous supporter,
Leone McKay, any gift you make - up to a total of $150,000
- can have double the impact. Her pledge is made in honor of her
late husband, Col. William P. McKay, whom she lost to Alzheimer's
disease, and will support vital research. Your gift can go 2X as far
toward advancing research and helping to provide care and support. We
only have until midnight tomorrow, and we urgently need you to stand
with us at this critical time. Will you make your first gift today
that can go 2X as far in the fight to end Alzheimer's?

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YES, I WILL BE PART OF THIS WORLD ALZHEIMER'S DAY MATCH
CHALLENGE

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U.S. POINTER Results Are In!

We're excited to report that results from U.S. POINTER -
a two-year clinical trial to evaluate whether lifestyle interventions
that simultaneously target many risk factors protect cognitive
function in older adults who are at risk for cognitive decline -
were presented at the 2025 Alzheimer's Association International
Conference
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® (AAIC®), and the findings give us hope.

About the study:
* 2,111 older adults were enrolled in the study from five
different regions across the country. More than 30% of
participants were from groups that have been historically
underrepresented in dementia research.
* Participants were randomly assigned to either a self-guided or
structured lifestyle program. Both interventions focused on
increasing physical activity, improving nutrition, cognitive and
social challenge and health monitoring - but differed in
structure, accountability and support provided.

Results:

Cognitive function improved from baseline over the two years
for both intervention groups, but the improvement was greater for the
structured group. This extra benefit was similar across all subgroups
of U.S. POINTER participants.

The positive results of U.S. POINTER encourage us to look at
the potential for a combination of a lifestyle program and drug
treatment as the next frontier in our fight against cognitive decline
and dementia.

Healthy Habits for Your Brain

Here are just a few positive, everyday actions that could make
a difference in lowering the risk of cognitive decline and possibly
Alzheimer's and dementia. With a gift that can double in impact during
our World Alzheimer's Day 2X Match Challenge, you can help make more
educational resources like our

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10 Healthy Habits for Your Brain available, as well as accelerate
research and help provide care and support to millions impacted by
Alzheimer's.

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Your Gift Can Go 2X As Far in Honor of Someone You Love
This World Alzheimer's Day.

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This World Alzheimer's Day, and every day, we honor and
cherish those we have lost to this disease. With a tribute gift today,
you can leave a lasting legacy for a loved one and help further our
mission to lead the way to end Alzheimer's and all other dementia
- by accelerating global research, driving risk reduction and
early detection, and maximizing quality care and support.

If you make your gift before our World Alzheimer's Day 2X
Match Challenge ends at midnight tomorrow, your gift can go 2X further
in the fight to end this devastating disease so that no one will have
to lose a loved one to Alzheimer's.

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MAKE A TRIBUTE GIFT

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   DONATE NOW   

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Alzheimer's Association

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800.272.3900     |

    alz.org
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®     |     Donate

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Your donation will strengthen our efforts to advance
Alzheimer's care, support and research. From face-to-face support to
online education programs and promising global research initiatives,
your gift makes a difference in the lives of all those affected by
Alzheimer's and other dementias in your community and across the
world. Thank you for your continued support.

Alzheimer's Association Home Office, 225 N. Michigan Ave.,
Fl. 17, Chicago, IL 60601

© 2025 Alzheimer's Association. All rights
reserved.

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