From Dr. James Amatruda, CHLA <[email protected]>
Subject 🦋 The science and beauty of transformation
Date June 27, 2025 9:03 PM
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Children's Hospital Los Angeles
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Dear John,

Have you ever noticed our logo? It's a butterfly.

You might think it's because the bright colors are welcoming to our young patients. That's true.
But there's more. A butterfly represents something important to all of us at Children's Hospital
Los Angeles: the science and beauty of transformation. That's the driving force behind
everything we do. We help kids get through unthinkable illnesses and walk out of our hospital
happier, while supporting their families every step of the way. We live out our mission to create hope and build healthier futures.

And, for the next few days, you can have a greater impact on these transformations: every
dollar you give will TRIPLE in impact, up to $100,000.

Please help CHLA make the absolute most of this triple match with a donation of $10 TODAY.


Triple My Gift:
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Transformations take time, dedication, and support.

With over 1,600 ongoing clinical research studies and 597 clinical trials, CHLA is one of the
largest and most productive pediatric research facilities in the United States. And because we're
a research institute and a hospital, the discoveries happening here can be fast-tracked to the
kids in our care who need it most. We can't afford to lose a moment and that's why we're
turning to you.

Thanks to your support, CHLA has made major breakthroughs, including:

* A revolutionary new treatment that gives hemophilia patients new freedom. CHLA
researchers were at the forefront of validating a new gene therapy for hemophilia, a blood
clotting disorder that causes uncontrollable bleeding. "I was so stunned when my care team
told me that if everything goes well, we can just discontinue my weekly infusions," says 24-year-
old Ryan. "When I was a kid, I was basically told this is what I'd be doing for the rest of my life."
Donate $10 to bring new hope to families. >>

* Groundbreaking gene therapy that has been a game-changer for muscular dystrophy. At 4
years old, Eliot was the first patient at CHLA to receive Elevidys, a new treatment for Duchenne
muscular dystrophy. Before his treatment, Eliot got winded just walking down the block, but
today he runs and jumps with ease. Donate $10 to support more clinical trials like this one. >>

* A potential new, less-toxic approach to treating leukemia that greatly minimizes the harmful
short-term and long-term side effects. "This would be a completely different way to kill cancer,"
says Yong-Mi Kim, MD, PhD, MPH, an investigator in the Cancer and Blood Disease Institute at
CHLA. "If it works, you may not even need chemotherapy." Double your impact for pioneering
research with a $10 gift. >>

Every breakthrough that happens at CHLA means hope and transformation for a family. That's
what your $10
donation today can provide.

Thank you for your dedication and commitment to improving children's health, and for
believing, like we do, that every child deserves hope and healing.

Sincerely,


James F. Amatruda, MD, PhD headshot.

James F. Amatruda, MD, PhD
Chief, Division of Pediatric Hematology-Oncology
Director, Cancer and Blood Disease Institute
Alfred E. Mann Family Foundation Chair in Cancer Research





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