Long-term investment in basic research can help us find a cure

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** Special Edition: 25th Anniversary
CURE Epilepsy Discovery
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** Funding Basic Mechanisms Research Drives Momentum Toward a CURE
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Research of basic biological mechanisms is the foundation of advances in the field of epilepsy. For 25 years, CURE Epilepsy has been funding work such as the Infantile Spasms (IS) Initiative to increase fundamental knowledge and move us closer to a cure for epilepsy.

Since 1998, CURE Epilepsy has funded over 280 research grants, and many have addressed the need to learn more about the basic biological mechanisms that underlie epilepsy. Many of these grants have formed the basis for further study, learning, and advancements that may lead us to a cure. One example of this is within infantile spasms (IS) ([link removed]) , a rare and particularly severe form of epilepsy, with approximately 90% of cases diagnosed in the first year of life. Infantile spasms manifest as sudden, jerking movements of the arms and legs, and are often accompanied by an irregular brainwave pattern on the electroencephalogram (EEG) called hypsarrhythmia.[1] These seizures are also often accompanied by significant cognitive and physical deterioration.[2] Current therapies for IS are effective in only half of the children with IS and are associated with negative side effects, highlighting the need to find better and more
effective treatments.

In 2013, CURE Epilepsy launched the Infantile Spasms Initiative ([link removed]) , with $4 million in funding. The IS Initiative employed a multi-disciplinary and multi-location team science approach to study the basic biological mechanisms underlying IS, search for biomarkers and novel drug targets, and develop improved treatments. Work done as part of the IS Initiative proved successful across multiple dimensions and led to more than 19 publications. More about the IS Initiative can be found here ([link removed]) .
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Today's CURE Epilepsy Discovery has the ability to help the 65 million people worldwide
who are impacted by epilepsy every day.
And each one of those individuals has a story.
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Our mission is to find a cure for epilepsy, by promoting and funding patient-focused research. CURE Epilepsy is a non-profit 501(c)(3) tax-exempt organization.Our tax identification number is 36-4253176.
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