Read the latest information


Cystic Fibrosis Foundation Standard Logo

INFECTION RESEARCH UPDATE

Infection research remains a top priority for the Cystic Fibrosis Foundation. As we approach the new year, we are excited to report on all the latest news on studies either funded by the Foundation or facilitated through its clinical trial network, the
Therapeutics Development Network ([link removed]).

Today, we announced that we invested $4.85 million in
Aridis Pharmaceuticals ([link removed])
to continue testing a non-traditional anti-infective that could help fight antibiotic-resistant bacteria. Aridis completed enrollment of its Phase 2a clinical trial in November and expects to report some data in the first quarter of 2023.

Two industry-led clinical trials to develop treatments for nontuberculous mycobacteria (NTM) infections in people with cystic fibrosis are either underway or in planning:

*
Beyond Air ([link removed])
reported positive safety, tolerability, and efficacy data in October from its LungFit GO pilot study of inhaled nitric oxide to treat NTM in people with CF.
*
Matinas Biopharma ([link removed])
plans to start a Phase 2 trial of oral amikacin to treat NTM in people with CF in 2023.

In other news, Idera Pharmaceuticals announced recently it will soon start a Phase 2 trial to test a potential treatment for pulmonary exacerbations in people with CF. Initial data are expected in the second half of 2023. (In September, Idera bought Aceragen Inc., the parent company of Arrevus Inc. In January, the Foundation
awarded Arrevus ([link removed])
$3.5 million to test this potential treatment).

Spotlight on Pseudomonas

Because of the prevalence of Pseudomonas aeruginosa in people with CF and the growth of multi-drug resistant strains, the Foundation is aggressively pursuing treatments for these bacteria. More than 28% of people with CF tested positive for Pseudomonas, according to the
2021 Patient Registry Annual Data Report ([link removed]).

Pseudomonas research projects compose almost 40% of our infection research portfolio with a third of that funding going toward developing new treatments. Since the launch of the
Infection Research Initiative ([link removed])
in 2018, eight new drug development programs targeting Pseudomonas infections have been funded, three of which use bacteriophage (phage) therapy. The latest updates on phage programs that target Pseudomonas in people with CF include:

*
BiomX Inc. ([link removed])
began dosing patients in June in
Part 1 ([link removed])
of a Phase 1b/2a study to test the safety and tolerability of phage therapy. Results from Part 1 are expected in the first half of 2023, followed by results from
Part 2 ([link removed])
in the second half of the year.
*
Armata Pharmaceuticals ([link removed])
will complete enrollment in its Phase 2a trial by the end of 2022. Top-line data are expected in 2023.



Advocacy

In addition to investing in infection research, the Foundation has been advocating for passage of the
PASTEUR Act ([link removed])
— federal legislation to support the development of new antibiotics and promote appropriate use of existing ones. In addition to meeting with members of Congress, the Foundation partnered with five organizations to launch a
grassroots advocacy campaign ([link removed])
to promote PASTEUR.

Want to join the effort?
Urge your member of Congress to cosponsor the PASTEUR Act today ([link removed]).

The Cystic Fibrosis Foundation periodically sends out information regarding our infection research efforts. To learn more about drugs in development and current studies, please check out the links below.


DRUG DEVELOPMENT PIPELINE ([link removed])


CLINICAL TRIAL FINDER ([link removed])




To receive periodic updates on the latest research, sign up below and choose 'research'

[SIGN UP FOR RESEARCH UPDATES]([link removed])


DONATE ([link removed])


[Opt out]([link removed] "opt out of this mailing list") of this mailing list |
Opt out ([link removed])
of all CFF emails


([link removed])
% link:[link removed] name="[link removed]" content="" %]
% link:[link removed] name="[link removed]" content="" %]
% link:[link removed] name="[link removed]" content="" %]


4550 Montgomery Avenue, Suite 1100N | Bethesda, MD 20814 US

This email was sent to [email protected].
To continue receiving our emails, add us to your address book.