PNES, also known as functional seizures, have long been thought to be caused by psychological factors such as anxiety and post-traumatic stress disorder. However, a new study finds that PNES is associated with structural changes in the brain that can be seen using MRI. A team of researchers analyzed more than 650 clinical-grade MRIs, comparing images from patients with PNES to those who did not experience seizures and could have other mental health conditions, such as depression and anxiety. The results of the study revealed that patients with PNES had thinning in an area of the brain called the superior temporal cortex, which affects a person's cognitive awareness and control of one's actions, and thickness in an area of the brain called the left occipital cortex, responsible for the processing of visual and other sensory information. These changes were not present in people who had depression, anxiety, or obsessive-compulsive disorder. The researchers hope that by understanding changes in the brain associated with PNES, therapies can be developed to counter these changes and treat PNES.
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