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** 04 May 2022
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** UK
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** Northern Lights: Sheffield has one of the lowest smoking in pregnancy rates in Yorkshire (#1)
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** New smoking survey is being launched across Herefordshire and Worcestershire (#2)
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** International
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** US: Cytisinicline shows statistically significant smoking cessation results in Phase 3 trial of adult smokers (#3)
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** UK
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** Northern Lights: Sheffield has one of the lowest smoking in pregnancy rates in Yorkshire
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**
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** Writing in the Star, Greg Fell, Director of Public Health for Sheffield City Council discusses Sheffield’s public health strategy to reduce infant mortality through reducing smoking in pregnancy.
Fell discusses how the Council has worked in partnership with families, communities, the NHS and voluntary organisations since 2010 to address eight key public health concerns - breastfeeding, maternal smoking, recessive genetic conditions, child poverty, maternal weight, early access to maternity care, teenage conception and safer sleep.
Sheffield’s “comprehensive” strategy for tackling smoking in pregnancy has subsequently become something the city does “amazingly well”, Fell explains. This strategy has involved the implementation of a smoke free hospital policy, midwifery stop smoking provision, significant support from consultants, relapse prevention and carbon monoxide monitoring. Fell also highlights the health visiting service’s focus on preventing relapse to smoking through brief interventions, as well as communications and campaigns.
According to Fell, this work has contributed to Sheffield now having the second-lowest rate of smoking in pregnancy in Yorkshire and successfully reducing infant mortality from 116 in 2001-2003 to 62 in 2018-2020.
Fell concludes with a word of caution about recent rises in sudden infant death rates and widening inequalities in infant mortality rates, but highlights that despite this, “there ARE successes [in public health] and that public health isn’t only covid”.
Source: The Star, 3 May 2022
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Read Article ([link removed] )
** New smoking survey is being launched across Herefordshire and Worcestershire
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**
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** A new survey is being launched across Herefordshire and Worcestershire asking smokers ex-smokers, and vapers about quitting smoking. The aim of the research is to help understand what support people who want to stop smoking might need.
The online survey ([link removed]) is available until Friday 3rd June and focus groups will be running during this period.
Councillor Karen May, cabinet member for Health and Wellbeing said: “Stopping smoking is one of the best things you will ever do for your health. It not only improves your physical health but also is proven to boost your mental health and wellbeing. Quitting can improve mood, and help relieve stress, anxiety and depression.”
“This survey will help us make sure the right support is available to help people achieve their stop smoking goals. If you're able to take part in either the survey or a focus group, we'd love to hear your views.”
The research will be used as part of a new Smoking Needs Assessment, used by local Public Health to help commission services and interventions for community smoking and tobacco stopping smoking.
Source: Worcestershire County Council, 3 May 2022
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Read Article ([link removed])
** International
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** US: Cytisinicline shows statistically significant smoking cessation results in Phase 3 trial of adult smokers
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**
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** Topline results from the phase 3 ORCA-2 trial of cytisinicline demonstrated significantly better quit rates than placebo in smoking cessation among adult smokers.
The trial was designed to evaluate the efficacy and safety of 3 mg cytisinicline dosed 3 times daily for a period of 6 weeks or 12 weeks compared to placebo in 810 adult smokers. The subjects were monitored for smoking abstinence for 24 weeks post randomization and received standard behavioural support for the duration of the trial.
As for the primary endpoints, both the 6 and 12 week cytisinicline treatments demonstrated significantly better quit rates than placebo, with odds ratios of 8.0 and 6.3, respectively, according to the study.
Participants who received 12 weeks of cytisinicline treatment had 6.3 times higher odds to have quit smoking during the last 4 weeks of treatment versus participants who received placebo. Their abstinence rate during weeks 9 to 12 was 32.6% for cytisinicline compared to 7.0% for placebo.
Participants who received 6 weeks of cytisinicline treatment had 8 times greater odds of quitting smoking during the last 4 weeks of treatment compared to subjects who received placebo. Their abstinence rate during weeks 3 to 6 was 25.3% for cytisinicline compared to 4.4% for placebo.
“Cytisinicline demonstrated impressive efficacy for smoking cessation compared to placebo in this trial, the first large randomized clinical trial conducted in a US population,” said Nancy Rigotti, MD, professor of medicine at Harvard Medical School, and principal investigator of ORCA-2.
Source: Pharmacy Times, 3 May 2022
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**
See also: ORCA-3 - Ongoing Research for Cytisinicline for Addiction ([link removed])
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