During this season of giving, please make your gift while it can be matched 2X.

Dear John, This incredible $200,000 Holiday Match Challenge is truly a gift — and it couldn't come at a more crucial time. The more than 6 million people in America living with Alzheimer's, along with their over 11 million caregivers, are counting on you and me to provide compassionate, high-quality care and support — while also giving them hope this holiday season. Research is moving forward and will one day make our vision of a world without Alzheimer's and all other dementia a reality. Please don't miss this chance to double your impact in the fight against Alzheimer's. A generous donor who wishes to remain anonymous has pledged to match all gifts up to $200,000 — if we raise the same amount by December 31. This donor's gift will support the Tau Pipeline Enabling Program (T-PEP), a funding initiative to accelerate drug development breakthroughs that could help mitigate the toxic effects of tau protein "tangles" in the brain. Because tau tangles are implicated in a number of neurodegenerative disorders, the research made possible by T-PEP could potentially benefit individuals living with Alzheimer's, Parkinson's disease, frontotemporal dementia and more. And with your holiday gift today, you can double your impact in the fight against Alzheimer's and help further our efforts to provide much-needed care and support and accelerate global research. Please make your first gift to the Alzheimer's Association today. We call the holidays the season of hope, and your commitment to helping provide care and support services, along with advancing research toward methods of treatment, prevention and, ultimately, a cure, is so critical at this time. The more than 750 active best-of-field projects in 39 countries provide all of us with the hope that we can — one day — end Alzheimer's. John, please don't miss the chance to double your impact on our work to provide care and support and accelerate critical research. Will you make your first gift now? Of course, the holidays are not just a time of hope but also of gratitude. And believe me when I say that everyone here at the Alzheimer's Association is grateful for you and your support of our mission to lead the way to end Alzheimer's and all other dementia — by accelerating global research, driving risk reduction and early detection, and maximizing quality care and support. Thank you in advance for helping us reach this critical goal and close out the year by making a big impact in the fight against Alzheimer's. Your gift can go twice as far in the fight to end Alzheimer's. Sincerely, Donna McCullough Chief Mission and Field Operations Officer P.S. Please take advantage of this $200,000 Holiday Match Challenge to double your impact on our work to provide Alzheimer's care and support and accelerate vital research.

Your donation will strengthen our efforts to advance Alzheimer's care, support and research. From face-to-face support to online education programs and promising global research initiatives, your gift makes a difference in the lives of all those affected by Alzheimer's and other dementias in your community and across the world. Thank you for your continued support. Alzheimer's Association Home Office, 225 N. Michigan Ave., Fl. 17, Chicago, IL 60601 © 2021 Alzheimer's Association. All rights reserved. 800.272.3900 | alz.org® | Donate Please add [email protected] to your address book to ensure you receive all future emails.   Having trouble reading this email? View it in your browser   View your email preferences or unsubscribe.