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Cleveland Clinic First-In-Human Trial of CRISPR Gene-Editing Therapy Shown to Safely Lower Cholesterol and Triglycerides - Nov 11, 2025
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| Subject | Cleveland Clinic First-In-Human Trial of CRISPR Gene-Editing Therapy Shown to Safely Lower Cholesterol and Triglycerides - Nov 11, 2025 |
| Date | November 11, 2025 12:19 AM |
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Dundee and US surgeons achieve world-first stroke surgery using robot
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from Scotland and the US have completed what is thought to be a
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Continued here
Work reading, ad-free. Expense Premium
[[link removed]}&lead=419599&emailid=252419&nl=daily].
Work
Cleveland Clinic First-In-Human Trial of CRISPR Gene-Editing Therapy
Shown to Safely Lower Cholesterol and Triglycerides
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
One-time infusion of investigational CRISPR-Cas9 therapy found to
safely reduce LDL cholesterol by 50% and triglycerides by about 55% in
Phase 1 trial
Work
China rolls out its version of the H-1B visa to attract foreign tech
workers
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
China has a new visa scheme that is creating job opportunities for
foreign professionals, part of its effort to attract global talent and
gain an edge in global technology.
Work
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[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
IDF soldiers tell documentary of opening fire unprovoked and arbitrary
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Ultra-endurance athletes test the metabolic limits of the human body
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
When ultra-runners lace up for races that stretch hundreds of miles
and days, they're not merely testing their mental grit and muscle
strength--they're probing the limits of human biology. Reporting in
Current Biology, researchers found that even the most extreme athletes
cannot surpass an average "metabolic ceiling" of 2.5 times their basal
metabolic rate (BMR) in energy expenditure.
Work
South Korea's ex-president Yoon indicted on new charges
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
A special prosecutor accused Yoon Suk Yeol, South Korea's ousted
president, of trying to stoke tensions by ordering drones into North
Korea.
Work
A Texas church's online class trains Christians to run for office. Now
it may go national
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
Fort Worth's Mercy Culture Church aims to get more conservative
Christians elected through its online Campaign University.
Work
No More Dumb Sperm: Danish Sperm Bank Sets New IQ Bar
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
A Danish sperm bank has imposed a minimum IQ requirement of 85, which
disqualified 18% of applicants, igniting debate on genetics, ethics
and reproduction.
Work
Nuclear 03: How Nuclear Reactors Work
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
Nuclear reactors come in many different forms, shaped by technical
constraints and strategic priorities. This essay explores the various
commercial architectures, revealing industry trends that explain
today's nuclear landscape and influence tomorrow's.
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25 years of meatbags permanently in space on the ISS
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
: All good things come to an end, and the outpost is unlikely to reach
30
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Scam Ads Are Flooding Social Media. These Former Meta Staffers Have a
Plan - WIRED [[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
Rob Leathern and Rob Goldman, who both worked at Meta, are launching a
new nonprofit that aims to bring transparency to an increasingly
opaque, scam-filled social media ecosystem.
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Stock traders might miss Pelosi after she retires | CNN Politics
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
There's a cottage industry of investors who monitor former House
Speaker Nancy Pelosi's disclosed stock trades, match her every move,
and usually make a profit along the way.
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The Lisbon Airport is turning away private jets inbound for the Web
Summit
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
A bottleneck at the Lisbon Airport is reportedly forcing some Web
Summit attendees to land their private jets hours away from Portugal.
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Germany mulls ban on buying sex to fight exploitation
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
With forced prostitution reportedly on the rise in Germany,
politicians are debating ways to reduce exploitation in sex work. Some
say the "Nordic model," which punishes clients rather than sex
workers, is the answer.
Work
Denver study shows removing parking requirements results in more
affordable housing being built
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
Structured parking can cost as much as $50,000 per space, making
housing more expensive to build and for those living there.
Work
Texas voters approve $3bn brain health research bill
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
Historic vote heralds one of the largest ever public investments in
neuroscience and neurodegenerative disease research.
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UK transport and cyber-security chiefs investigate Chinese-made buses
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
Move to assess potential risk of remote meddling by Beijing with
Yutong buses follows investigations in Norway and Denmark
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The first new subsea habitat in 40 years is about to launch | MIT
Technology Review [[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
Unveiled by the buzzy startup Deep, Vanguard will let teams of
scientists live and work on the seabed for a week at a time.
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What we lose when we surrender care to algorithms | Eric Reinhart
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
A dangerous faith in AI is sweeping American healthcare - with
consequences for the basis of society itself
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Trump Tries to Seize 'Affordability' as Americans' Economic Worries
Grow
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[[link removed]}&lead=419599&emailid=252419&nl=daily]
The issue has buoyed Democrats and is resonating with an American
electorate that is souring on the president’s economic agenda.
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OpenAI CEO Sam Altman was served with a subpoena live onstage
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
The interruption came during a discussion about technology,
inequality, and wealth. Altman was asked about the gap between Nvidia
CEO Jensen Huang’s $179 billion fortune and the millions of
Americans losing access to food assistance, but he said Huang
“isn’t responsible for people losing benefits” and has done
“wonderful things for the country and the economy,” per the Daily
Mail.
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US Senate passes deal aimed at ending longest ever government shutdown
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
Follow the twists and turns of Trump's second term with North America
correspondent Anthony Zurcher's weekly US Politics Unspun newsletter.
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here.
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At COP30 in Belm, Brazil, Chinese Technology Is Shifting Climate
Politics
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[[link removed]}&lead=419599&emailid=252419&nl=daily]
At this year’s climate summit, the United States is out and Europe
is struggling. But emerging countries are embracing renewable energy
thanks to a glut of cheap equipment.
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Your Party row erupts over hundreds of thousands of pounds in
donations
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
Sultana’s supporters however point to her following among young
leftwingers and her success at getting her message across to an online
audience. Her TikTok following, for example, is now nearly 490,000, in
comparison with Corbyn’s 280,000.
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Drug dealer granted clemency by Trump sent back to prison for
violating terms of release
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
Braun was sentenced to 10 years in federal prison in 2019 after
pleading guilty to drug-related charges. He served about a year behind
bars before the US president commuted his sentence in the final days
of his first term in January 2021.
Work
Ghislaine Maxwell eyeing commutation, whistleblower tells House
Democrats
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
“Ghislaine Maxwell is a convicted sex offender who helped Jeffrey
Epstein commit atrocities and rape against women and girls for
decades,” Garcia said. “For months, we have been warning the
American people that Trump’s Department of Justice is providing her
with unprecedented benefits as a prisoner, including moving her to a
less restrictive facility.
Work
Canada loses measles elimination status ?as does the entire Americas
region
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
Helen Branswell covers issues broadly related to infectious diseases,
including outbreaks, preparedness, research, and vaccine development.
Follow her on Mastodon and Bluesky. You can reach Helen on Signal at
hbranswell.01.
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Medicaid's 'GENEROUS' pricing may not save states money
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
Morning, morning. Today, we have a trio of interesting studies on
cholesterol reduction from the American Heart Association’s meeting
in New Orleans. Also, Pfizer wins the Metsera deal with $10 billion,
and we look at Trump’s GLP-1 deal more closely.
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Senate takes first step toward ending the government shutdown
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
And in Washington, home to tens of thousands of federal workers who
have gone unpaid, the Capital Area Food Bank said it is providing 8
million more meals ahead of the holidays than it had prepared for
this budget year — a nearly 20% increase.
Work
Why women are embracing testosterone
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
Testosterone might contribute to higher libido, more strength, and
energy -- but it's not FDA-approved to treat menopause. There are some
risks with off-label usage.
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How thousands of fossil fuel lobbyists got access to UN climate talks
- and then kept drilling
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
Exclusive: Research shows oil, gas and coal firms' unprecedented
access to Cop26-29, blocking urgent climate action
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Why the BBC Is Facing Its Gravest Crisis in Decades
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
The British public service broadcaster apologized on Monday for a
misleadingly edited documentary about President Trump. But the scandal
had already claimed two of its top executives.
Work
Trump Threatens to Sue the BBC for $1 Billion After Jan. 6 Documentary
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
A lawyer for President Trump said the BBC’s editing of a speech he
gave was “defamatory.” The broadcaster apologized on Monday for an
“error in judgment.”
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What to Know About the BBC Resignations and Turmoil Over a Trump
Speech Edit
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
Two top executives quit after a memo by a former adviser said that the
broadcaster had misleadingly edited a speech by President Trump.
Work
BBC board member with Tory links 'led charge' in systemic bias claims,
say insiders
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
It warns that should the deadline be missed, Trump will be "left with
no alternative but to enforce his legal and equitable rights, all of
which are expressly reserved and are not waived, including by filing
legal action for no less than 1,000,000,000 dollars in damages".
Work
Suits Accuse Camp Mystic of Gross Negligence in Children's Deaths
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
Parents of campers and counselors who died in the July 4 Texas floods
said the camp leadership did little before mounting “a hopeless
‘rescue’ effort from its self-created disaster.”
Work
3 San Antonio Officers Acquitted in Fatal Shooting of Woman in 2023
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
Melissa Perez, 46, swung a hammer in their direction and appeared to
be in distress in her home when the officers arrived, officials said.
Work
Travelers Battle More Flight Disruptions Amid Shutdown Talks
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
The travel turmoil led some fliers to embark on time-consuming detours
as they monitored talks in Washington to end the government shutdown.
Work
Groups Sue to Reverse Trump's Cuts to Energy Projects in Democratic
States
[[link removed]}&lead=419599&emailid=252419&nl=daily]
[[link removed]}&lead=419599&emailid=252419&nl=daily]
A lawsuit filed on Monday argued that the president has discriminated
against blue states by slashing federal funds for political leverage
during the shutdown.
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