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As of October 8, 2025, CDC’s newly
revised Terms of Reference (ToR) include ingredient-specific
safety evaluations, with a direct focus on aluminum adjuvants and
associated risks, including asthma.
The updated Terms of Reference asks: “Do either of the two
different aluminum adjuvants increase the risk of asthma?” This
language marks the first formal acknowledgment by ACIP that aluminum
hydroxide and aluminum phosphate, the primary adjuvants in most
pediatric vaccines, may merit differentiated toxicological scrutiny.
This change places the issue within the Workgroup’s formal priority
and scope, not as a fringe or side issue.
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