͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌ ͏‌To prevent cruelty to animals, we promote enacting and enforcing good public policies. To enact good laws, we must elect good lawmakers, and that’s why we remind voters which candidates care about our issues and which ones don’t. If you’d like to unsubscribe, click here. [[link removed]]

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Dear Friend,
Thousands of beagles are languishing at Ridglan Farms, a breeding facility with as many as 5,000 dogs who will soon be on their way to laboratories for painful invasive testing.
The breed, so trusting and compliant, is the perfect experimental subject for people who don’t give a damn about the well-being of dogs. Unless we run this company out of this trade in dogs as “testing models,” the beagles are doomed.
State and federal inspections and whistleblower testimony show that the Wisconsin-based company confines dogs in barren, overcrowded cages. With little to no socialization. Untreated injuries, deficient veterinary care.
A recent court ruling found probable cause that Ridglan may have committed multiple criminal violations.
The good news is, there are only two of these massive beagle breeding facilities supplying dogs to labs. The other giant, though, is Marshall BioResources in upstate New York, with more than 20,000 beagles bred for this same purpose.
It’s cruelty masquerading as science.
Testing using animals is wildly inaccurate in predicting the human reaction to drugs. It fails 95% of the time.
With the campaign culminating in 2022, we lobbied Congress that beagle testing is inhumane and inefficient and unreliable. That year, Congress approved the FDA Modernization Act 2.0 to start us down the path of eliminating this senseless cruelty, thanks to especially capable leadership from U.S. Sens. Rand Paul, M.D., R-Ky., and Cory Booker, D-N.J.
With your help, we ended an 84-year-old mandate requiring animal tests for all new drug approvals.
And when Dr. Marty Makary became FDA commissioner in April, his very first major act — enabled by our reform — was the release of a landmark Roadmap to Reducing Animal Testing in Preclinical Safety Studies. [[link removed]] This roadmap provides the blueprint for replacing animal tests with modern, human-relevant science. The bold plan seeks to make animal testing the exception, not the norm, for preclinical safety studies.
Makary says his aim is to replace animal models with new alternative methods (NAMs) like computational modeling, specialized engineered tissues, and human-specific systems.
The question remains, after Makary’s announcement, why are we still battling with Ridglan Farms and its house of horror for beagles?
Our nation should have learned from the horror show at Envigo in Virginia — a massive beagle-breeding operation where thousands of dogs were kept in squalid cages, denied care, and bred only to suffer in laboratories. Ridglan Farms is just one more cog in a broken system of inhumane, unreliable drug testing.
We must charge ahead, embracing 21st-century science: organs-on-a-chip, organoids, spheroids, artificial intelligence, and other advanced human-based platforms that can help scientists develop cures and treatments faster, safer, and more effectively.
These methods can spare animals and deliver results that patients can trust.
Your support is critical to keep the pressure on, to enforce the FDA roadmap, and to close the beagle mills that feed the pipeline of animal cruelty. Together, we can ensure that no contract labs, pharma companies, or university labs have any interest in buying the tormented beagles coming from Ridglan or Marshall BioResources.
We want these companies to be known in the history books as infamous examples of the way things used to be done, before we embraced moral purpose and sound science. [[link removed]]

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One part of that future involves passing the FDA Modernization Act 3.0 (H.R. 2821 in the House and S. 355 in the Senate). Please do write your federal lawmakers in support of it.
And just as importantly, please support our work so that we can take on Ridglan, Charles River Laboratories, and the other companies that feed animals into a system that produces more suffering and does little to sustain life of any sort. [[link removed]]

FDA Modernization Action Alert [[link removed]]

“Life Sciences” has often been anything but that. Let’s turn it all around.
For all animals and people,

Wayne Pacelle [[link removed]] Wayne Pacelle
President
Animal Wellness Action
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