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Issue 1,833: September 17, 2025  
Top Stories
 
Immunize​.org Website and Clinical Resources 
 
Vaccine Information Statements
 
Featured Resources
 
Notable Publications
 
Upcoming Events
 
Top Stories

The Autism Society, Immunize​.org, and Vaccinate Your Family release “The Facts About Autism and Vaccines” infographic 

The Autism Society, Immunize​.org, and Vaccinate Your Family partnered to create an infographic titled The Facts About Autism and Vaccines. This resource provides simple facts about common myths and misconceptions. This valuable tool emphasizes the scientific research showing no link between vaccines and autism. As the topic of vaccines and autism resurfaces widely online and in clinical offices in response to comments made by the HHS Secretary, this resource can help reassure and support families with facts.



View the infographic.

Related Links


Immunize​.org updates "Ask the Experts: RSV (Respiratory Syncytial Virus)," adding clesrovimab information

Immunize​.org updated the clinical content of our Ask the Experts: RSV (Respiratory Syncytial Virus) web page to reflect recent recommendation changes and the addition of clesrovimab (Enflonsia, Merck) as an RSV preventive antibody product option for infants. Answers also cover the new lower recommended age for vaccinating high-risk adults (now beginning at age 50 years). Three new questions and answers were added:

  • What is clesrovimab preventive antibody and how well does it work?
  • What are the storage requirements for clesrovimab?
  • Is palivizumab (Synagis, AstraZeneca) recommended for any infant?

Immunize​.org’s Ask the Experts main page leads you to 30 web pages on various topics with more than 1,300 common or challenging questions and answers about vaccines and their administration. Immunize​.org’s team of experts includes Kelly L. Moore, MD, MPH (team lead); Carolyn B. Bridges, MD, FACP; Iyabode Beysolow, MD, MPH; and Jane Zucker, MD, MSc.

Related Links

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American Academy of Family Physicians publishes fall immunization recommendations, urging protection against COVID-19, influenza, and RSV

On September 8, the American Academy of Family Physicians (AAFP) published its own evidence-based recommendations for COVID-19, influenza, and RSV vaccination. The American Academy of Family Physicians is the national association of family doctors. The AAFP’s recommendations are consistent with those recently issued by the American Academy of Pediatrics (AAP) and the American College of Obstetricians and Gynecologists (ACOG).

For COVID-19, AAFP's schedule calls for routine COVID-19 vaccination of all adults age 18 years and older, as well as young children age 6 through 23 months. They recommend administering the vaccine to children age 2 through 17 years whose family wants them to be protected. They also recommend COVID-19 vaccination during any trimester of pregnancy. These recommendations from AAFP align with recommendations of AAP and ACOG.

For influenza, AAFP recommends an annual influenza vaccination for everyone age 6 months and older without medical contraindications. This is consistent with current CDC, AAP, and ACOG recommendations. 

For RSV, the AAFP supports the current CDC recommendation, published on the 2025 CDC Recommended Adult Schedule, recommending a onetime RSV vaccination for adults age 75 and older, and for adults age 50 through 74 years at increased risk. They recommend the use of Abrysvo RSV vaccine at the appropriate gestational stage of pregnancy. All infants younger than age 8 months not protected through maternal Abrysvo vaccination should receive nirsevimab (Beyfortus, Sanofi) or clesrovimab (Enflonsia, Merck).

Related Link


“Influenza-Associated Hospitalizations During a High Severity Season—Influenza Hospitalization Surveillance Network, United States, 2024–25 Influenza Season” published in MMWR

CDC published Influenza-Associated Hospitalizations During a High Severity Season—Influenza Hospitalization Surveillance Network, United States, 2024–25 Influenza Season on September 11 in MMWR. Preliminary data on influenza-associated hospital admissions from October 1, 2024, through April 30, 2025, show the cumulative influenza-associated hospitalization rate was higher than all end-of-season rates going back to the 2010–11 season. Key facts include:

  • Cumulative 2024–25 season hospitalization rates were highest among people age 75 years or older
  • Across age groups, rates during the 2024–25 season were 1.8 to 2.8 times higher than median historical rates during the period beginning with the 2010–11 season
  • Like past seasons, most patients (89%) hospitalized with influenza during the 2024–25 season had one or more underlying medical conditions
  • 17% of hospitalized people were admitted to an intensive care unit, 6% required mechanical ventilation, and 3% died in hospital



Access the MMWR article in HTML or PDF.

Related Link

  • CDC: MMWR main page providing access to the MMWR family of publications

Immunize​.org updates “Ask the Experts: Influenza” questions and answers for 2025–26 season

Immunize​.org revised its Ask the Experts: Influenza web page, updating content for the 2025–26 influenza season and revising hyperlinks to CDC web pages. Clinical answers address recent ACIP changes to recommendations about the use of preservative-containing multidose vials. Where relevant, answers provide links to 2025–26 season influenza vaccination recommendations from the American Academy of Pediatrics and the American College of Obstetricians and Gynecologists.

Immunize​.org’s Ask the Experts main page leads you to 30 web pages on various topics with more than 1,300 common or challenging questions and answers about vaccines and their administration. Immunize​.org’s team of experts includes Kelly L. Moore, MD, MPH (team lead); Carolyn B. Bridges, MD, FACP; Iyabode Beysolow, MD, MPH; and Jane Zucker, MD, MSc.

Related Links

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Immunize​.org updates the season on its Spanish translations of screening checklists for contraindications to influenza vaccination

Immunize​.org updated the season information (i.e., 2025–26) on its Spanish-language versions of the influenza screening checklists. No substantive changes were made to the patient questions. The English language content on the back of the form matches recent minor updates to the English versions of the checklists.

      

Related Links


Prepare your influenza season communications with resources from leading organizations

As the fall respiratory virus season begins, remind patients, family, and friends how important it is to vaccinate against influenza, COVID-19, and RSV. Strong recommendations from trusted healthcare providers remain one of the most effective drivers of vaccine confidence and uptake. Several organizations offer toolkits and educational resources you can use to strengthen conversations and advocate for vaccination. 

  • NFID: Wild to Mild: A campaign highlighting the importance of influenza vaccination by contrasting “wild” influenza illness with the “milder” outcomes among those vaccinated. Includes patient-friendly visuals and messaging.
  • CDC: Respiratory Illness Season Toolkit: A toolkit with guidance, messaging, and graphics to support healthcare professionals and public health leaders throughout respiratory virus season.
  • HHS: Risk Less. Do More.: A public health campaign to encourage people, especially older adults, to get vaccinated against influenza, COVID-19, and RSV. 
  • Families Fighting Flu: Flu's Clues: An interactive game designed for families to learn about flu prevention in an engaging way.
  • Vaccinate Your Family: Winter Wellness web page: This page guides families through staying protected during respiratory virus season. A comprehensive toolkit is expected soon.
  • AIM: Connecting the Dots: Influenza Vaccination Resources: A 1-page resource guide to support immunization managers and clinicians in coordinating communication around influenza vaccination.
  • Immunize Kansas Coalition: Kansas Fights Flu: Toolkits, social media materials, and campaign resources tailored to influenza vaccination advocacy and outreach.



Related Link

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Immunize​.org adds recent advances to its “Vaccine History Timeline”

Do you need to know the year that CDC made a vaccination recommendation or FDA first licensed a vaccine? Refer to Immunize​.org’s Vaccine History Timeline. This useful resource was updated to include recent vaccine-related events.



If you would like to suggest an event to add, contact us at [email protected].


“Ensure Pediatricians Know About Maternal RSV Vaccination Status.” Watch the 1-minute video, part of the Ask the Experts Video Series on YouTube. 

This week, our featured episode from the Ask the Experts Video Series is titled Ensure Pediatricians Know About Maternal RSV Vaccination Status. The video highlights the importance of documenting maternal RSV vaccination. Without clear documentation and communication, pediatric practices and families may face added challenges in tracking records, and infants could receive unnecessary doses of RSV preventive antibody.

The 1-minute video is available on our YouTube channel, along with our full collection of quick video answers to popular Ask the Experts questions.

Like, follow, and share Immunize​.org’s social media accounts and encourage colleagues and others interested in vaccination to do likewise.


Vaccines in the news

These recent articles convey the potential risks of vaccine-preventable diseases and the importance of vaccination.


Immunize​.org Website and Clinical Resources

Spotlight on the website: What’s new on Immunize​.org

Use What’s New on Immunize.org to view the timeline of content changes on our website. This feature helps you quickly find Immunize​.org’s recently updated Ask the Experts sections, clinical resources, VISs, translations, or other web pages. 
 
How to access “What’s New on Immunize​.org”: 

  • Click on the “News & Updates” tab on the menu bar atop each page 
  • Click on “What's New on Immunize​.org” 
 

Next, you will see a reverse chronologic list of website updates. 
 

 
Filter results by resource, vaccine/disease, year, month, or status (new or updated). Click on the hyperlinked result to access the desired content. 


Recap: Immunize​.org posts its up-to-date 2025–26 suite of influenza vaccination resources

Immunize​.org completed the annual review of our entire suite of influenza clinical resources for the 2025–26 season. All materials have a new date in the footnote to indicate they were reviewed and are current for the 2025–26 season, even if no content changes were necessary. These resources include:

These updated resources were announced in recent editions of IZ Express:  Find all of our influenza vaccine resources for the 2025–26 season at the Vaccines A–Z: Influenza main page.
 

Recap: Immunize​.org updates “Ask the Experts: Zoster (Shingles)” questions and answers

Immunize​.org's team of experts reviewed and updated all questions and answers in Ask the Experts: Zoster (Shingles). There have been no changes to federal recommendations for the use of recombinant zoster vaccine (RZV, Shingrix, GSK) since the previous update in 2022.

Changes added specific criteria for a healthcare provider-verified history of varicella disease, and information about the manufacturer-filled syringe (MFS) presentation. The MFS is now available in addition to the presentation that requires reconstitution. Hyperlinks were added or updated as needed. No new questions were added.

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Vaccine Information Statements

Recap: Immunize​.org posts Spanish translations of both updated pneumococcal VISs

Immunize​.org posted Spanish translations of the two current pneumococcal VISs that were updated by CDC on May 29, 2025.

To locate VIS translations for a particular vaccine, click on “Vaccines & VISs” at Immunize.org, click on “VISs,” and then select a specific vaccine. Scrolling down the resulting page, you will see the current English VIS (the official federal version), followed by a list of translations of the current English version. Where applicable, current translations are followed by a list of translations of past English versions that are still usable because they are the most recent translations available in those languages. When a patient is given any VIS translation, they should also receive the current official VIS, which is in English. Additional tips on using VISs appear at the bottom of the web page.

Check the version date of your inventory of VIS translations. Discard translations of previous versions as translations of current versions become available.
 
Featured Resources

Hepatitis B Foundation shares media toolkit to combat misinformation about the HepB birth dose 

To emphasize the critical importance of the hepatitis B birth dose for newborns, the Hepatitis B Foundation created a comprehensive media toolkit. This resource includes fact sheets, ready-to-use social media messages, and other materials to help you and your organization share accurate, consistent information about protecting infants from hepatitis B. As the ACIP weighs discontinuing the longstanding, successful routine HepB birth-dose program, use these resources to champion the value of hepatitis B prevention for all infants.

View the toolkit.


Vaccinate Your Family shares its free, online Vaccination Community Learning Program covering the essentials of vaccine science, safety, communication, and access 

Vaccinate Your Family offers its VYF University's flagship program, Vaccination Community Learning Program (VCLP). This program is a set of free online courses describing the essentials of vaccine science, safety, communication, and access. It is designed for community health workers, healthcare providers, advocates, or anyone interested in protecting their community. VCLP courses include: 

  • Vaccine basics and how vaccines work  
  • Strategies to address misinformation  
  • How to navigate vaccination barriers  
  • Tips for talking with people about vaccines  

Enroll in VCLP

Related Link


CHOP’s Vaccine Education Center shares new video and podcast series that aims to help families get vaccine information easily

The Children’s Hospital of Philadelphia’s (CHOP) Vaccine Education Center (VEC) offers its new VEC Vaccine Notes series, which relays vaccine information in both video and podcast formats for people on the go. Each episode is based on one of VEC's Vaccines and Diseases web pages. Each describes the diseases vaccines prevent, the vaccines available, answers to common questions, and vaccination risks and benefits.

Season 1 will feature 10 episodes released weekly on Wednesdays through mid-November.

“VEC Video Notes” is available on YouTube and can be listened to via podcast at: Podbean, Apple Podcasts, Spotify, iHeartRadio, and PodChaser



Visit the VEC Vaccine Notes web page.
 
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“Human Papillomavirus and Cancer” published by New England Journal of Medicine in its Double Take Video Series  

In a Double Take video (13:35 minutes) from the New England Journal of Medicine, Julie Barzilay, MD, discusses the link between certain types of HPV and cancer as well as the evidence supporting the safety and effectiveness of HPV vaccination in reducing the risk of these cancers.   
 

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Common Health Coalition launches fall respiratory viral season resources, including scenario planning toolkits for payers and providers 

The Common Health Coalition offers three toolkits of fall respiratory season resources to help payers, providers, health systems, and public health leaders address respiratory disease season. Common Health Coalition is a project coordinated by the Public Good Projects, a nonprofit organization specializing in large-scale media monitoring, social and behavior change interventions, and cross-sector initiatives. These toolkits were made possible with funding from Kaiser Permanente.

  • Payers Toolkit: Resources for health plans and insurers to guide vaccine coverage decisions, communications, and member engagement
  • Providers Toolkit: Practical tools and materials to help healthcare providers integrate updated vaccine guidance and strengthen patient communication
  • States Toolkit: Guidance for state health leaders and agencies to coordinate vaccine distribution, outreach, and system-wide planning

Use these toolkits to help promote vaccine messaging and uptake.

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Notable Publications

"Aluminum-Adsorbed Vaccines and Chronic Diseases in Childhood: A Nationwide Cohort Study" published in Annals of Internal Medicine

In its July 15 issue, Annals of Internal Medicine published Aluminum-Adsorbed Vaccines and Chronic Diseases in Childhood: A Nationwide Cohort Study. Portions of the abstract are paraphrased below.               

Design: A cohort study linking nationwide registry data on childhood vaccinations, outcome diagnoses, and potential confounders, leveraging the variations in the aluminum content of childhood vaccines over time. Data come from Denmark, 1997 to 2020.

Conclusion: This nationwide cohort study found no evidence supporting an increased risk for autoimmune, atopic or allergic, or neurodevelopmental disorders associated with early childhood exposure to aluminum-adsorbed vaccines. For most outcomes, the findings were inconsistent with moderate to large relative increases in risk, although small relative effects, particularly for some rarer disorders, could not be statistically excluded.

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“Hospitalization for COVID-19 and Risk Factors for Severe Disease Among Children: 2022–2024” published in Pediatrics  

In its August 1 issue, Pediatrics published Hospitalization for COVID-19 and Factors for Severe Disease Among Children: 2022–2024. A portion of the abstract appears below. 

Of 2490 children hospitalized for COVID-19, 1114 (44.7%) were aged 6 to 23 months; 1358 (54.1%) were male. Overall, 1464 (58.9%) had at least 1 underlying condition . . . One hundred (3.8%) were up to date with recommended COVID-19 vaccination. Among children aged 6 to 23 months, severe disease was associated with underlying chronic lung . . . and cardiovascular disease . . . Among children aged 2 years and older, severity was associated with chronic lung disease . . . diabetes . . . and neurologic disorders . . . 

. . . COVID-19 vaccination, particularly among children with high-risk conditions, may reduce pediatric COVID-19 hospitalizations and severe outcomes. 



“Recognizing a Few of the Vaccine Preventable Diseases” published in Pediatrics in Review  

In its September 2025 issue, Pediatrics in Review published Recognizing a Few of the Vaccine Preventable Diseases. This article presents information on preventable diseases for which vaccination rates are declining. Providers may not have seen patients with these diseases and may not know how to recognize them. Pediatrics in Review developed a series of images formatted as flash cards that depict some of the most serious vaccine-preventable diseases to aid in recognition, treatment, and understanding of potential outcomes.


Upcoming Events

Virtual: September 18–19 ACIP meeting will discuss and vote on MMRV, HepB, and COVID-19 vaccines

CDC will convene the ACIP today and tomorrow, September 18–19. The draft agenda, posted late on September 12, shows the meeting will discuss and vote on MMRV, HepB, and COVID-19 vaccines. Experts representing professional medical societies and other vaccination stakeholders were excluded from ACIP work groups earlier this summer.

No registration is required to watch webcasts of live ACIP meetings or listen via telephone. 

Related Links


Virtual and in-person: Clinical Care Options hosts three events centered around childhood vaccination on last Saturday and Monday of September; CME available                            

Clinical Care Options will host three vaccine-focused events this September, both virtually and in person at the AAP Experience in Denver. The events include:

AMA, ANCC, and ACPE credit is available at no charge for some events.


Register for Immunize​.org Website Office Hours. Join a 30-minute discussion about the Clinical Resources web section on October 8 at 4:00 p.m. (ET) or October 9 at 12:00 p.m. (ET). Recorded sessions archived.

To learn simple tips and tricks for using our website efficiently, please register for our next set of Website Office Hours on Wednesday, October 8, at 4:00 p.m. (ET) or Thursday, October 9, at 12:00 p.m. (ET). The same content will be covered in both sessions.

We will open each 30-minute session with a short, live demonstration on navigating the popular Clinical Resources website section on Immunize​.org. You can submit questions when you register or live on Zoom during the session.

Register today for Immunize​.org Website Office Hours (content is the same for both):

The archive of previous Website Office Hours content is posted at Immunize​.org’s "Webinars & Videos" page.

Mark your calendar for future Immunize​.org Website Office Hours.


For more upcoming events, visit our Calendar of Events.
Editorial Information

Editor-in-Chief
Kelly L. Moore, MD, MPH
Managing Editor
John D. Gräbenstein, RPh, PhD
Associate Editor
Sharon G. Humiston, MD, MPH
Writer/Publication Coordinator
Taryn Chapman, MS
Courtnay Londo, MA
Style and Copy Editor
Marian Deegan, JD
Web Edition Managers
Arkady Shakhnovich
Jermaine Royes
Contributing Writer
Laurel H. Wood, MPA
Technical Reviewer
Kayla Ohlde
 
About IZ Express
Immunize​.org welcomes redistribution of this issue of IZ Express or selected articles.
When you do so, please add a note that Immunize​.org is the source of the material and provide a link to this issue.

IZ Express is supported in part by Grant No. NH23IP922654 from the National Center for Immunization and Respiratory Diseases, CDC. Its contents are solely the responsibility of Immunize​.org and do not necessarily represent the official views of CDC.

IZ Express Disclaimer
ISSN: 2771-8085






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