Revealing research breakthroughs for Alzheimer's care.
Dear Friend,
The Alzheimer's Association International Conference® 2025 (AAIC®) contains the latest advances on every aspect of dementia research and care. The world's leading researchers, clinicians and dementia professionals are sharing breaking research discoveries and important updates that could lead to new methods of treatment and prevention.
We're excited to report that results from the U.S. POINTER study — a two-year clinical trial to evaluate whether lifestyle interventions that simultaneously target many risk factors protect cognitive function in older adults who are at risk for cognitive decline — were presented at AAIC, and the findings give us hope.
The Key Findings:
U.S. POINTER found that, in people at risk for cognitive decline and dementia, a multidomain lifestyle intervention improved cognitive function over two years — with even greater improvement from a more intense intervention — protecting cognition from normal age-related decline for nearly two years.
This means that, relative to the self-guided group, participants in the structured group performed at a level comparable to adults 1 to 2 years younger in age — an effect that likely increases resilience against cognitive decline.
These positive results underscore the message that healthy behavior has a powerful impact on brain health. With your help, over the next four years, we’ll invest $40 million to bring the U.S. POINTER recipe into communities around the country. This includes an extension of the trial to follow U.S. POINTER participants to understand the longer-term impact of these lifestyle interventions, as well as collaborations with health systems and health agencies to turn the trial findings into action for people in all communities. Here are several initiatives you can expect to see in the coming months:
A personal brain health assessment tool to help people create their own brain health game plan
An interactive, case-based virtual brain health training program to help health care providers promote brain health among their patients
A brain health and dementia-capable Community Recognition Program to recognize employers, health care systems and communities that champion brain health and deliver quality care and support
A Brain Health Roundtable to bring together the brightest minds among health care, public health, community and corporate leaders.
We are in a new era in brain health. This was one of the largest and most ambitious lifestyle intervention trials for brain health in United States history. The results will have a real impact on Americans for generations to come — but it is just the beginning.
Kind-hearted people like you who support Alzheimer's research make the U.S. POINTER study and other clinical trials possible. To learn more about research breakthroughs, I encourage you to register and attend AAIC For All: Community. This no-cost, single day community event will be held both online and in person on July 31, where global experts will showcase research highlights from AAIC 2025 and expand your knowledge of dementia, diagnosis, treatment, risk reduction and dementia care.
I'm excited to think about the exchange of ideas happening this week at AAIC. As you read about new breakthroughs, there's a good chance many of them may have started with the people at this year's conference. That's not only a reflection on those researchers, scientists and healthcare professionals — it's also a reflection on the strength of our community's commitment.
With appreciation,
Maria C. Carrillo, Ph.D.
Chief Science Officer and Medical Affairs Lead
P.S. Friend, there is still time to take part in AAIC For All: Community to learn about the latest research findings, either in person or online, on July 31. Please consider taking part. We're thrilled to allow our supporters access to groundbreaking research in Alzheimer's and dementia clinical care and science, wherever they are. We hope you are encouraged by what you hear and that you'll be inspired to join us in the fight with a gift today.
Your donation will strengthen our efforts to advance Alzheimer's care, support and research. From face-to-face support to online education programs and promising global research initiatives, your gift makes a difference in the lives of all those affected by Alzheimer's and other dementias in your community and across the world. Thank you for your continued support.
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