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Epilepsy Research
News
July 2025
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This month, we share the following articles and abstracts which are furthering the study of epilepsy and bringing the world closer to a cure.
* High blood pressure in pregnancy linked to increased risk of seizure in children ([link removed])
* Comprehensive study maps genetic mutations in SLC13A5 linked to epilepsy ([link removed])
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** High blood pressure in pregnancy linked to increased risk of seizure in children
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A new study has revealed a significant association between high blood pressure during pregnancy (gestational hypertension) and an increased risk of seizures in children. The findings also suggest that inflammation in the brain may play a role in connecting gestational hypertension to seizure risk and could potentially be targeted to prevent seizures in children exposed to hypertension in the womb.
The study analyzed data from the Epic Cosmos dataset, which includes over 246 million patient records from hospitals and clinics across the United States and Lebanon. The researchers found that children born to mothers with high blood pressure during pregnancy had significantly higher rates of seizures compared to those born to mothers with normal blood pressure.
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** Comprehensive Study Maps Genetic Mutations in SLC13A5 Linked to Epilepsy
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Scientists have comprehensively studied the function and structure of the citrate transporter encoded by the gene SLC13A5.
Citrate, the negatively charged ion of citric acid, is a key component in the metabolism of every cell. In neurons, citrate plays an especially important role; as a so-called "neuromodulator," it influences neuronal activity. Neurons express high levels of the citrate transporter to facilitate citrate uptake. When this transporter is not fully functional due to genetic mutations, it can lead to SLC13A5 Citrate Transporter Disorder, a severe form of epilepsy associated with impaired brain development (also referred to as developmental epileptic encephalopathy). However, until now, little was known about which mutations impact the function of the transporter and how they influence disease progression.
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