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IZ Express #1,818: mNexspike COVID-19 vaccine, vaccine administration records, and more
| From | Immunize.org <[email protected]> |
| Subject | IZ Express #1,818: mNexspike COVID-19 vaccine, vaccine administration records, and more |
| Date | June 11, 2025 10:16 AM |
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Issue 1,818: June 11, 2025
Top Stories
* FDA licenses Moderna's next generation mRNA COVID-19 Vaccine (mNexspike) for people age 12 to 64 years with high-risk conditions and all adults age 65 and older. ACIP will consider recommendations for its use at its June meeting.
* Immunize.org updates “Vaccine Administration Record for Children and Teens” and “Vaccine Administration Record for Adults”
* Immunize.org updates references in two more standing orders templates
* Immunize.org updates its "Notification of Immunization Letter Template"
* For National Men’s Health Week, June 9–15, encourage men to seek preventive care, including vaccination. Happy Father’s Day!
* Confirmed measles cases increase to 1,168 across 33 states; encourage vaccination
* Journalists interview Immunize.org experts
* Vaccines in the news
Immunize.org Website and Clinical Resources
* Spotlight on the website: "Ask the Experts" topics and subtopics
* Summary: Updated Immunize.org clinical resources released in April and May
* Recap: Immunize.org updates “Administering Vaccines: Dose, Route, Site, and Needle Size”
Vaccine Information Statements
* Summary: Spanish and Pohnpeian VIS translations released in April and May
* Recap: CDC issues two updated VISs for pneumococcal vaccines
Featured Resources
* Vaccinate adults! Order laminated 2025 U.S. adult immunization schedule booklets.
* Help Immunize.org reach more vaccinators through your social media networks. Follow us and share our posts on Facebook, Instagram, and LinkedIn!
Notable Publications
* "Trends in County-Level MMR Vaccination Coverage in Children in the United States" published in JAMA
Upcoming Events
* Virtual: Register for Immunize.org Website Office Hours. Ask questions and learn about our "News & Updates" web section on June 11 at 4:00 p.m. (ET) or June 12 at 12:00 p.m. (ET). Recorded sessions archived.
* Virtual: AIM hosts webinar, “Responding to Measles Outbreaks in High Priority Populations Part II,” on June 17 at 2:00 p.m. (ET)
* Virtual: NFID hosts webinar, “Protecting Patients Before Travel,” on June 18 at 1:00 p.m. (ET); CE credit offered
* Virtual: Watch June 25–27 ACIP meeting with discussion of several vaccine recommendations, including COVID-19, HPV, influenza, meningococcal, and RSV
Editorial Information
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Top Stories
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FDA licenses Moderna's next generation mRNA COVID-19 Vaccine (mNexspike) for people age 12 to 64 years with high-risk conditions and all adults age 65 and older. ACIP will consider recommendations for its use at its June meeting.
On May 30, FDA licensed mNexspike (Moderna) to prevent COVID-19 disease in adults age 65 years and older as well as those age 12 through 64 years with at least one underlying condition that elevates their risk for severe outcomes from COVID-19 ([link removed]). Among other differences, a dose of mNexspike contains 10 mcg of messenger RNA, compared to 50 mcg in Moderna’s Spikevax messenger RNA vaccine.
At its June 25–27 meeting, ACIP will consider its recommendations for use of all available COVID-19 vaccines.
FDA posted the mNexspike package insert ([link removed]) and approval letter ([link removed]).
Related Link
* Immunize.org: Vaccines A–Z: COVID-19 ([link removed]) main page
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Immunize.org updates “Vaccine Administration Record for Children and Teens” and “Vaccine Administration Record for Adults”
Immunize.org updated vaccine administration records for children and teens ([link removed]) and for adults ([link removed]), adding Penmenvy (MenABCWY, GSK), which was licensed on February 14, 2025. ACIP voted on recommendations for its use at the April meeting; these recommendations are pending acceptance by the CDC Director or Secretary of Health.
Related Links
* Immunize.org: Clinical Resources: Administering Vaccines ([link removed]) main page
* Immunize.org: Clinical Resources A–Z ([link removed]) main page, where you can filter by topic, vaccine, language, or other criteria
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Immunize.org updates references in two more standing orders templates
Immunize.org continues to update its standing orders templates ([link removed]) to remove the reference to the excipient table that used to appear in Appendix B ([link removed]) of the Epidemiology and Prevention of Vaccine-Preventable Diseases (the "Pink Book"). The two updated standing order templates posted in the past week are:
* Standing Orders for Administering Meningococcal ACWY Vaccine to Children and Teens ([link removed])
* Standing Orders for Administering Meningococcal ACWY Vaccine to Adults ([link removed])
Previously announced updated standing orders templates include:
* Standing Orders for Administering Rotavirus Vaccine to Infants ([link removed])
* Standing Orders for Administering Human Papillomavirus Vaccine to Children and Teens ([link removed]) (additional update to font and QR code)
* Standing Orders for Administering Human Papillomavirus Vaccine to Adults ([link removed])
* Standing Orders for Administering Hepatitis A Vaccine to Children and Teens ([link removed])
* Standing Orders for Administering Hepatitis A Vaccine to Adults ([link removed])
* Standing Orders for Administering Varicella Vaccine to Adults ([link removed])
* Standing Orders for Administering Varicella Vaccine to Children and Teens ([link removed])
* Standing Orders for Administering Haemophilus influenzae Type B Vaccine to Adults ([link removed])
* Standing Orders for Administering Pneumococcal Vaccines to Children and Teens ([link removed])
Related Links
* Immunize.org: Clinical Resources: Standing Orders Templates ([link removed]) main page
* Immunize.org: Clinical Resources A–Z ([link removed]) main page, where you can filter by topic, vaccine, language, or other criteria
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Immunize.org updates its "Notification of Immunization Letter Template"
Immunize.org updated its Notification of Immunization Letter Template ([link removed]), adding Penmenvy (MenABCWY, GSK), which was licensed on February 14, 2025. ACIP voted on recommendations for its use at the April meeting; these recommendations are pending acceptance by the CDC Director or Secretary of Health.
Related Links
* Immunize.org: Clinical Resources: Documenting Vaccination ([link removed]) main page
* Immunize.org: Clinical Resources A–Z ([link removed]) main page, where you can filter by topic, vaccine, language, or other criteria
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For National Men’s Health Week, June 9–15, encourage men to seek preventive care, including vaccination. Happy Father’s Day!
National Men's Health Week ([link removed]) is June 9–15, ending on Father's Day. This annual observance encourages men of all ages to prioritize their health and seek preventive care including recommended vaccines ([link removed]). Compared with women, men generally die earlier, become ill at a younger age, and develop more chronic illnesses, but are up to 50% less likely ([link removed]) to seek medical care. According to CDC ([link removed]), more than 14% of adult men are in fair or poor health.
Encourage men to get up to date with vaccination. Men can learn what they may need in this easy-to-read version of CDC’s Recommended Immunizations for Adults ([link removed]). In addition to vaccines needed by age or health status, some may need additional vaccines based on their occupation. CDC resources on Traveler’s Health ([link removed]) address vaccines needed for international travel. Also see Immunize.org's resource, Vaccinations for Men Who Have Sex with Men ([link removed]), for information about additional vaccines recommended for them, including mpox vaccine.
The HPV vaccine ([link removed]) is critical cancer prevention for all young adults and teens, helping to prevent HPV-associated cancers of the mouth, throat, and genitals. Currently, about 16,000 HPV-associated cancers occur in men each year. All males age 9 through 26 years should be protected from HPV-related cancers through vaccination; men age 27 through 45 years should talk with their healthcare provider to decide if they would benefit.
Happy Father's Day to all the fathers among our IZ Express readers! Thank you for all you do to safeguard your family’s health. Remember to take care of your vaccination needs, too.
Related Links
* CDC: Men's Health ([link removed]) main page
* CDC: Immunization Schedules ([link removed]) main page
* Immunize.org: Vaccinations for Men Who Have Sex with Men ([link removed]) (PDF)
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Confirmed measles cases increase to 1,168 across 33 states; encourage vaccination
As of June 5, CDC reported 1,168 confirmed measles cases ([link removed]) in 2025 in 33 states, including the first case reported this year in South Dakota ([link removed]). This case occurred in an adult resident of Meade County who became ill after international travel. The states with the most confirmed cases in 2025 are Texas (742, 63.5%) ([link removed]) and Kansas (71, 6.1%) ([link removed]). Among confirmed cases, 12% were hospitalized and two out of three were younger than age 20 years.
CDC only requires reporting of laboratory-confirmed measles cases. Cases without laboratory testing for confirmation are not included in these numbers. Actual numbers of cases are, therefore, higher than confirmed case counts.
A map of 2025 measles cases ([link removed]) in the contiguous United States, as of June 6, from the Johns Hopkins International Vaccine Access Center ([link removed]) appears below. The U.S. Measles Tracker ([link removed]) website includes state and county-level data.
CDC updated its Travelers' Health: Global Measles ([link removed]) web page to encourage all international travelers to be fully vaccinated before travel. Additionally, CDC offers resources for communities experiencing a measles outbreak including infographics for families, images to help clinic personnel identify cases, guidance for caring for patients with measles ([link removed]), and a Be Ready for Measles communication toolkit ([link removed]). Spanish-language resources ([link removed]) are now available on the toolkit page.
Related Links
* CDC: Measles Cases and Outbreaks ([link removed]) main page
* CDC: Be Ready for Measles Toolkit ([link removed])
* Center for Outbreak Response Innovation: Measles Outbreak Response ([link removed]) main page
* Immunize.org: Vaccines A–Z: Measles ([link removed]) main page
* Immunize.org: Standing Orders for Administering Measles, Mumps, and Rubella Vaccine to Children and Teens ([link removed]) (PDF)
* Immunize.org: Standing Orders for Administering Measles, Mumps, and Rubella Vaccine to Adults ([link removed]) (PDF)
* Immunize.org: Ask the Experts: MMR (Measles, Mumps, and Rubella) ([link removed]) web page
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Journalists interview Immunize.org experts
Journalists seek out Immunize.org experts to help explain vaccines to the public and policy makers. We help the media understand and communicate the complex work vaccinators do. Here is a recent citation.
* NPR: COVID Vaccine Changes Confuse and Upset Some Parents and Families ([link removed]) (6/3/25)
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Vaccines in the news
These recent articles convey the potential risks of vaccine-preventable diseases and the importance of vaccination.
* Washington Post: RFK Jr. Purges Every Vaccine Adviser on CDC Panel; Will Pick Replacements ([link removed]) (6/9/25)
* New York Times: Whooping Cough Is Surging. Do You Need Another Shot? ([link removed]) (6/6/25)
* American Journal of Managed Care: ACP Experts Say FDA, CDC Moves May Undermine COVID-19 Vaccine Coverage for Millions ([link removed]) (6/2/25)
* New York Times: Kennedy Says Healthy Kids Don’t Need COVID Shots. Is That True? ([link removed]) (5/27/25)
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Immunize.org Website and Clinical Resources
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Spotlight on the website: "Ask the Experts" topics and subtopics
This week, we continue highlighting our popular “Ask the Experts ([link removed])” section. This resource provides more than 1,300 practical answers to questions from healthcare professionals about vaccines and vaccine administration. Content is divided into two categories:
* Vaccine Topics—22 specific vaccines
* General Topics—10 vaccination-related categories
Larger topics feature subcategories to assist with your search.
[link removed]
Look at the left navigation menu. If there is a carat (>) next to the topic, click to expand the list of subcategories available. Clicking on a subcategory such as “Vaccine Recommendations” will filter results.
Browse the resulting questions or narrow your results with keyword search (marked 1 in the image above) or by choosing filters (2). Select the “Hide All Answers/Show All Answers” button (3) to hide or expand answer content. In the illustration above, “Hepatitis A,” followed by “Vaccine Recommendations,” and the keyword “Twinrix” produces two results.
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Summary: Updated Immunize.org clinical resources released in April and May
IZ Express regularly provides readers with information about Immunize.org’s new and updated educational materials for healthcare professionals and handouts for patients. All Immunize.org materials are free to distribute.
In case you missed them during recent weeks, updates were made to the following helpful materials.
Immunize.org Updated Materials for Clinicians
Standing Orders Templates: see Top Story above for list.
Materials Supporting Immunization Services:
* Checklist of Current Versions of U.S. COVID-19 Vaccination Guidance and Clinic Support Tools ([link removed])
* Vaccine Storage Quick Reference ([link removed])
* Vaccine Storage Troubleshooting Record ([link removed])
Immunize.org Web Pages:
* Vaccine History Timeline ([link removed])
* New! Website Office Hours: Publication Archives, Vaccine Timeline, & About Us ([link removed])
* New! Website Office Hours: Affiliated Websites ([link removed])
Immunize.org Updated Printable Materials for Your Patients
* Human Papillomavirus (HPV): Questions and Answers ([link removed])
* Human Papillomavirus (HPV): A Parent’s Guide to Preteen and Teen HPV Vaccination ([link removed])
* HPV Vaccine: A Guide for Adults Ages 18–26 Years ([link removed])
Related Links
* Immunize.org: Clinical Resources: Screening Checklists ([link removed]) main page
* Immunize.org: Clinical Resources A–Z ([link removed]) main page to see educational materials sorted by category
* Immunize.org: Ask the Experts ([link removed]) main page to access more than 1,200 questions answered by Immunize.org experts
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Recap: Immunize.org updates “Administering Vaccines: Dose, Route, Site, and Needle Size”
Immunize.org recently updated its clinical resource titled Administering Vaccines: Dose, Route, Site, and Needle Size ([link removed]) to add Penmenvy, the new MenABCWY vaccine from GSK.
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Vaccine Information Statements
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Summary: Spanish and Pohnpeian VIS translations released in April and May
IZ Express provides readers with information about new and updated VISs, translations, and resources. In April, Immunize.org provided updated Spanish translations (PDF and RTF for electronic medical record systems). In May, the Cerro Gordo County Public Health Department generously donated 16 new Pohnpeian VIS translations to post on the website.
The table below contains hyperlinks to the English vaccine VISs, 15 updated Spanish translations, and 16 new Pohnpeian translations.
COVID-19 ([link removed])
COVID-19 ([link removed]) COVID-19 ([link removed])
COVID-19 ([link removed])
Dengue ([link removed])
Dengue ([link removed])
Dengue ([link removed])
Haemophilus influenzae type b (Hib) ([link removed])
Haemophilus influenzae type b (Hib) ([link removed])
Hepatitis A ([link removed]) Hepatitis A ([link removed])
Hepatitis A ([link removed])
Hepatitis B ([link removed])
Hepatitis B ([link removed]) Hepatitis B ([link removed])
Hepatitis B ([link removed])
Influenza, live ([link removed])
Influenza, live ([link removed])
Influenza, live ([link removed])
Influenza, recombinant ([link removed])
Influenza, recombinant ([link removed])
Influenza, recombinant ([link removed])
Influenza, recombinant ([link removed])
Meningococcal ACWY ([link removed])
Meningococcal ACWY ([link removed])
Meningococcal ACWY ([link removed])
Meningococcal B ([link removed])
Meningococcal B ([link removed])
Meningococcal B ([link removed])
Meningococcal B ([link removed])
MMR ([link removed])
MMR ([link removed])
MMR ([link removed])
MMR ([link removed])
MMRV ([link removed])
MMRV ([link removed])
MMRV ([link removed])
MMRV ([link removed])
Multi-vaccine pediatric ([link removed])
Multi-vaccine pediatric ([link removed])
Polio ([link removed])
Polio ([link removed])
Polio ([link removed])
Polio ([link removed])
Pneumococcal conjugate ([link removed])
Pneumococcal conjugate ([link removed])
Rotavirus ([link removed])
Rotavirus ([link removed])
RSV ([link removed])
RSV ([link removed])
RSV ([link removed])
RSV ([link removed])
Smallpox-monkeypox ([link removed])
Smallpox-monkeypox ([link removed])
Smallpox-monkeypox ([link removed])
Smallpox-monkeypox ([link removed])
Td ([link removed])
Td ([link removed])
Tdap ([link removed])
Tdap ([link removed])
Tdap ([link removed])
Varicella ([link removed])
Varicella ([link removed])
Varicella ([link removed])
Varicella ([link removed])
Zoster ([link removed]) Zoster ([link removed])
Immunize.org offers three clinical resources that link to VISs via QR codes:
* QR Code Links to Routinely Recommended Vaccine Information Statements ([link removed])
* QR Code Links to All Vaccine Information Statements ([link removed])
* QR Code Links to Vaccine Information Statement (VIS) Translations: Influenza (Flu) Vaccine (Inactivated or Recombinant) ([link removed])
All these resources appear on our new Clinical Resources topic: VIS-Related Resources ([link removed]).
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Recap: CDC issues two updated VISs for pneumococcal vaccines
On May 29, CDC released updated VISs for pneumococcal polysaccharide vaccine (PPSV23) ([link removed]) and pneumococcal conjugate vaccine (PCV) ([link removed]). Changes incorporate recommendations for the routine use of PCV for adults age 50 years and older (previously 65 years) and the limited use of PPSV23. The updated VISs refer to PCVs generally and no longer reference specific PCV products.
The use of the updated VISs should begin immediately. If you use Immunize.org’s QR code reference resources linking directly to the English VISs ([link removed]) on our website, you can keep using them. These QR code documents automatically link to the updated VISs and ensure you are always accessing the current official version.
Immunize.org will create and post translations of these updated VISs in coming weeks. CDC notes that translated VISs that are out of date following publication of an updated version may continue to be used. The official English VIS must also be provided when providing any translation.
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Featured Resources
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Vaccinate adults! Order laminated 2025 U.S. adult immunization schedule booklets.
Laminated booklets of the 2025 U.S. adult immunization schedule ([link removed]) are still available in the Immunize.org shop. The 2025 child and adolescent schedule booklets sold out.
The schedules are available online as PDFs from CDC ([link removed]) at no cost. Immunize.org’s laminated booklets are ideal for use in any busy healthcare setting where vaccines are given.
Adult Booklets
1 copy: $10.00
2–4 copies: $9.50 each
5–19 copies: $8.50 each
20–99 copies: $7.50 each
100–499 copies: $6.00 each
500–999 copies: $5.00 each
1,000–1,999 copies: $4.00 each
2,000+ copies: $3.25 each
Visit the Shop Immunize.org: Laminated Schedules ([link removed]) web page to view images and order today!
For additional information, call 651-647-9009 or email [email protected].
Related Links
* Immunize.org: Laminated Adult Immunization Schedules (19 and older) ([link removed]) web page
* Immunize.org: Shop Immunize.org ([link removed]) main page
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Help Immunize.org reach more vaccinators through your social media networks. Follow us and share our posts on Facebook, Instagram, and LinkedIn!
Immunize.org offers a social media program to highlight our educational resources for a new audience of vaccinators. Our social media channels now feature our most popular printable resources and Ask the Experts questions, as well as announcements important to frontline vaccinators. Please view and share our newest feature, the Ask the Experts Video Series ([link removed]).
Like, follow, and share Immunize.org’s social media accounts and encourage colleagues and others interested in vaccination to do likewise:
* Facebook at ImmunizeOrg ([link removed])
* Instagram at ImmunizeOrg ([link removed])
* LinkedIn at Immunize.org ([link removed])
* YouTube at ImmunizeOrg ([link removed])
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Notable Publications
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"Trends in County-Level MMR Vaccination Coverage in Children in the United States" published in JAMA
In the June 2 issue, JAMA published Trends in County-Level MMR Vaccination Coverage in Children in the United States ([link removed]). Parts of the research letter appear below.
Childhood vaccination has substantially reduced the incidence of vaccine-preventable diseases and saved countless children’s lives worldwide. The U.S. childhood vaccination program is estimated to have prevented more than 24 million cases of vaccine-preventable diseases in 2019 alone. Nonetheless, there is evidence of a U.S. national-level decline in the childhood measles-mumps-rubella (MMR) vaccination rate between 2019 and 2024. . . .
Our county-level dataset complements the state and national-level CDC data, confirming a widespread decline in MMR vaccination rates in the US after the COVID-19 pandemic while revealing significant heterogeneity in vaccination patterns within and across states. This dataset can be used in spatial and statistical analyses to identify factors associated with low or declining MMR rates in US counties and help inform targeted vaccination strategies to reduce the risk of measles outbreaks.
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Upcoming Events
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Virtual: Register for Immunize.org Website Office Hours. Ask questions and learn about our "News & Updates" web section on June 11 at 4:00 p.m. (ET) or June 12 at 12:00 p.m. (ET). Recorded sessions archived.
To learn simple tips and tricks for using our website efficiently, please register for our next set of Website Office Hours on Wednesday, June 11 at 4:00 p.m. (ET) ([link removed]) or Thursday, June 12 at 12:00 p.m. (ET) ([link removed]). The same content will be covered in both sessions.
We will open each 45-minute session with a short, live demonstration on navigating ourNews & Updates ([link removed]).
Register today for Immunize.org Website Office Hours (content is the same for both):
* Wednesday, June 11 at 4:00 p.m. (ET) ([link removed])
* Thursday, June 12 at 12:00 p.m. (ET) ([link removed])
Th archive of previous Website Office Hours content ([link removed]) is posted at Immunize.org’s "Webinars & Videos" page. These archived programs include Ask the Experts; Clinical Resources; Vaccine Information Statements (VISs); Affiliated Websites; Images, Webinars, Videos, & Social Media; Official Guidance; Publication Archives, Vaccine Timeline, & About Us; Travel Vaccines, Vaccine Confidence, & Addressing Concerns; and Vaccines A–Z.
See our Calendar of Events ([link removed]) for future Immunize.org Website Office Hours.
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Virtual: AIM hosts webinar, “Responding to Measles Outbreaks in High Priority Populations Part II,” on June 17 at 2:00 p.m. (ET)
The Association of Immunization Managers (AIM) will present a 1-hour webinar titled Responding to Measles Outbreaks in High Priority Populations Part II ([link removed]) beginning at 2:00 p.m. (ET) on June 17.
Based on feedback from Part I, this webinar will focus on strategies and engagement with close-knit communities.
Register for the webinar ([link removed]).
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Virtual: NFID hosts webinar, “Protecting Patients Before Travel,” on June 18 at 1:00 p.m. (ET); CE credit offered
NFID ([link removed]) will host a webinar titled Protecting Patients Before Travel ([link removed]) at 1:00 p.m. (ET) on June 18. The panel includes NFID Medical Director Robert H. Hopkins Jr., MD; Chapman University School of Pharmacy Professor Jeffery A. Goad, PharmD, MPH; and ACIP member and Harvard Medical School Associate Professor Lin H. Chen, MD. Speakers will review current recommendations for travelers and share implementation strategies.
CME and CNE credit are available. There is no fee to participate in this activity, but preregistration is required.
Register for the webinar ([link removed]).
NFID hosts monthly webinars ([link removed]) to increase awareness of the importance of infectious disease prevention and treatment. CME, CNE, and CPE credits are available for select recordings. View all archived NFID webinars ([link removed]).
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Virtual: Watch June 25–27 ACIP meeting with discussion of several vaccine recommendations, including COVID-19, HPV, influenza, meningococcal, and RSV
CDC has been scheduled to convene the ACIP ([link removed]) on June 25–27. Recommendation votes are scheduled for COVID-19, HPV, influenza, meningococcal, and RSV vaccines. Additionally, the agenda includes discussion of vaccines targeting anthrax, chikungunya, cytomegalovirus (CMV), Lyme, and pneumococcal diseases.
A recent HHS decision led to the dismissal of all 17 members of ACIP ([link removed]). HHS intends to replace those 17 members with new members currently under consideration ([link removed]) and hold the June 25–27 meeting in Atlanta.
Related Links
* CDC: ACIP main page ([link removed]) for access to webcast, agendas
* CDC: ACIP: Meeting Information ([link removed]) for presentation slides, content from previous meetings, and information about future meetings
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For more upcoming events, visit our Calendar of Events ([link removed]).
Editorial Information
Editor-in-Chief
Kelly L. Moore, MD, MPH
Managing Editor
John D. Gräbenstein, RPh, PhD
Associate Editor
Sharon G. Humiston, MD, MPH
Writer/Publication Coordinator
Taryn Chapman, MS
Courtnay Londo, MA
Style and Copy Editor
Marian Deegan, JD
Web Edition Managers
Arkady Shakhnovich
Jermaine Royes
Contributing Writer
Laurel H. Wood, MPA
Technical Reviewer
Kayla Ohlde
About IZ Express
Immunize.org welcomes redistribution of this issue of IZ Express or selected articles.
When you do so, please add a note that Immunize.org is the source of the material and provide a link to this issue ([link removed]).
IZ Express is supported in part by Grant No. NH23IP922654 from the National Center for Immunization and Respiratory Diseases, CDC. Its contents are solely the responsibility of Immunize.org and do not necessarily represent the official views of CDC.
IZ Express Disclaimer (http:// [link removed])
ISSN: 2771-8085
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Issue 1,818: June 11, 2025
Top Stories
* FDA licenses Moderna's next generation mRNA COVID-19 Vaccine (mNexspike) for people age 12 to 64 years with high-risk conditions and all adults age 65 and older. ACIP will consider recommendations for its use at its June meeting.
* Immunize.org updates “Vaccine Administration Record for Children and Teens” and “Vaccine Administration Record for Adults”
* Immunize.org updates references in two more standing orders templates
* Immunize.org updates its "Notification of Immunization Letter Template"
* For National Men’s Health Week, June 9–15, encourage men to seek preventive care, including vaccination. Happy Father’s Day!
* Confirmed measles cases increase to 1,168 across 33 states; encourage vaccination
* Journalists interview Immunize.org experts
* Vaccines in the news
Immunize.org Website and Clinical Resources
* Spotlight on the website: "Ask the Experts" topics and subtopics
* Summary: Updated Immunize.org clinical resources released in April and May
* Recap: Immunize.org updates “Administering Vaccines: Dose, Route, Site, and Needle Size”
Vaccine Information Statements
* Summary: Spanish and Pohnpeian VIS translations released in April and May
* Recap: CDC issues two updated VISs for pneumococcal vaccines
Featured Resources
* Vaccinate adults! Order laminated 2025 U.S. adult immunization schedule booklets.
* Help Immunize.org reach more vaccinators through your social media networks. Follow us and share our posts on Facebook, Instagram, and LinkedIn!
Notable Publications
* "Trends in County-Level MMR Vaccination Coverage in Children in the United States" published in JAMA
Upcoming Events
* Virtual: Register for Immunize.org Website Office Hours. Ask questions and learn about our "News & Updates" web section on June 11 at 4:00 p.m. (ET) or June 12 at 12:00 p.m. (ET). Recorded sessions archived.
* Virtual: AIM hosts webinar, “Responding to Measles Outbreaks in High Priority Populations Part II,” on June 17 at 2:00 p.m. (ET)
* Virtual: NFID hosts webinar, “Protecting Patients Before Travel,” on June 18 at 1:00 p.m. (ET); CE credit offered
* Virtual: Watch June 25–27 ACIP meeting with discussion of several vaccine recommendations, including COVID-19, HPV, influenza, meningococcal, and RSV
Editorial Information
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Top Stories
------------------------------------------------------------
FDA licenses Moderna's next generation mRNA COVID-19 Vaccine (mNexspike) for people age 12 to 64 years with high-risk conditions and all adults age 65 and older. ACIP will consider recommendations for its use at its June meeting.
On May 30, FDA licensed mNexspike (Moderna) to prevent COVID-19 disease in adults age 65 years and older as well as those age 12 through 64 years with at least one underlying condition that elevates their risk for severe outcomes from COVID-19 ([link removed]). Among other differences, a dose of mNexspike contains 10 mcg of messenger RNA, compared to 50 mcg in Moderna’s Spikevax messenger RNA vaccine.
At its June 25–27 meeting, ACIP will consider its recommendations for use of all available COVID-19 vaccines.
FDA posted the mNexspike package insert ([link removed]) and approval letter ([link removed]).
Related Link
* Immunize.org: Vaccines A–Z: COVID-19 ([link removed]) main page
------------------------------------------------------------
Immunize.org updates “Vaccine Administration Record for Children and Teens” and “Vaccine Administration Record for Adults”
Immunize.org updated vaccine administration records for children and teens ([link removed]) and for adults ([link removed]), adding Penmenvy (MenABCWY, GSK), which was licensed on February 14, 2025. ACIP voted on recommendations for its use at the April meeting; these recommendations are pending acceptance by the CDC Director or Secretary of Health.
Related Links
* Immunize.org: Clinical Resources: Administering Vaccines ([link removed]) main page
* Immunize.org: Clinical Resources A–Z ([link removed]) main page, where you can filter by topic, vaccine, language, or other criteria
------------------------------------------------------------
Immunize.org updates references in two more standing orders templates
Immunize.org continues to update its standing orders templates ([link removed]) to remove the reference to the excipient table that used to appear in Appendix B ([link removed]) of the Epidemiology and Prevention of Vaccine-Preventable Diseases (the "Pink Book"). The two updated standing order templates posted in the past week are:
* Standing Orders for Administering Meningococcal ACWY Vaccine to Children and Teens ([link removed])
* Standing Orders for Administering Meningococcal ACWY Vaccine to Adults ([link removed])
Previously announced updated standing orders templates include:
* Standing Orders for Administering Rotavirus Vaccine to Infants ([link removed])
* Standing Orders for Administering Human Papillomavirus Vaccine to Children and Teens ([link removed]) (additional update to font and QR code)
* Standing Orders for Administering Human Papillomavirus Vaccine to Adults ([link removed])
* Standing Orders for Administering Hepatitis A Vaccine to Children and Teens ([link removed])
* Standing Orders for Administering Hepatitis A Vaccine to Adults ([link removed])
* Standing Orders for Administering Varicella Vaccine to Adults ([link removed])
* Standing Orders for Administering Varicella Vaccine to Children and Teens ([link removed])
* Standing Orders for Administering Haemophilus influenzae Type B Vaccine to Adults ([link removed])
* Standing Orders for Administering Pneumococcal Vaccines to Children and Teens ([link removed])
Related Links
* Immunize.org: Clinical Resources: Standing Orders Templates ([link removed]) main page
* Immunize.org: Clinical Resources A–Z ([link removed]) main page, where you can filter by topic, vaccine, language, or other criteria
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Immunize.org updates its "Notification of Immunization Letter Template"
Immunize.org updated its Notification of Immunization Letter Template ([link removed]), adding Penmenvy (MenABCWY, GSK), which was licensed on February 14, 2025. ACIP voted on recommendations for its use at the April meeting; these recommendations are pending acceptance by the CDC Director or Secretary of Health.
Related Links
* Immunize.org: Clinical Resources: Documenting Vaccination ([link removed]) main page
* Immunize.org: Clinical Resources A–Z ([link removed]) main page, where you can filter by topic, vaccine, language, or other criteria
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For National Men’s Health Week, June 9–15, encourage men to seek preventive care, including vaccination. Happy Father’s Day!
National Men's Health Week ([link removed]) is June 9–15, ending on Father's Day. This annual observance encourages men of all ages to prioritize their health and seek preventive care including recommended vaccines ([link removed]). Compared with women, men generally die earlier, become ill at a younger age, and develop more chronic illnesses, but are up to 50% less likely ([link removed]) to seek medical care. According to CDC ([link removed]), more than 14% of adult men are in fair or poor health.
Encourage men to get up to date with vaccination. Men can learn what they may need in this easy-to-read version of CDC’s Recommended Immunizations for Adults ([link removed]). In addition to vaccines needed by age or health status, some may need additional vaccines based on their occupation. CDC resources on Traveler’s Health ([link removed]) address vaccines needed for international travel. Also see Immunize.org's resource, Vaccinations for Men Who Have Sex with Men ([link removed]), for information about additional vaccines recommended for them, including mpox vaccine.
The HPV vaccine ([link removed]) is critical cancer prevention for all young adults and teens, helping to prevent HPV-associated cancers of the mouth, throat, and genitals. Currently, about 16,000 HPV-associated cancers occur in men each year. All males age 9 through 26 years should be protected from HPV-related cancers through vaccination; men age 27 through 45 years should talk with their healthcare provider to decide if they would benefit.
Happy Father's Day to all the fathers among our IZ Express readers! Thank you for all you do to safeguard your family’s health. Remember to take care of your vaccination needs, too.
Related Links
* CDC: Men's Health ([link removed]) main page
* CDC: Immunization Schedules ([link removed]) main page
* Immunize.org: Vaccinations for Men Who Have Sex with Men ([link removed]) (PDF)
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Confirmed measles cases increase to 1,168 across 33 states; encourage vaccination
As of June 5, CDC reported 1,168 confirmed measles cases ([link removed]) in 2025 in 33 states, including the first case reported this year in South Dakota ([link removed]). This case occurred in an adult resident of Meade County who became ill after international travel. The states with the most confirmed cases in 2025 are Texas (742, 63.5%) ([link removed]) and Kansas (71, 6.1%) ([link removed]). Among confirmed cases, 12% were hospitalized and two out of three were younger than age 20 years.
CDC only requires reporting of laboratory-confirmed measles cases. Cases without laboratory testing for confirmation are not included in these numbers. Actual numbers of cases are, therefore, higher than confirmed case counts.
A map of 2025 measles cases ([link removed]) in the contiguous United States, as of June 6, from the Johns Hopkins International Vaccine Access Center ([link removed]) appears below. The U.S. Measles Tracker ([link removed]) website includes state and county-level data.
CDC updated its Travelers' Health: Global Measles ([link removed]) web page to encourage all international travelers to be fully vaccinated before travel. Additionally, CDC offers resources for communities experiencing a measles outbreak including infographics for families, images to help clinic personnel identify cases, guidance for caring for patients with measles ([link removed]), and a Be Ready for Measles communication toolkit ([link removed]). Spanish-language resources ([link removed]) are now available on the toolkit page.
Related Links
* CDC: Measles Cases and Outbreaks ([link removed]) main page
* CDC: Be Ready for Measles Toolkit ([link removed])
* Center for Outbreak Response Innovation: Measles Outbreak Response ([link removed]) main page
* Immunize.org: Vaccines A–Z: Measles ([link removed]) main page
* Immunize.org: Standing Orders for Administering Measles, Mumps, and Rubella Vaccine to Children and Teens ([link removed]) (PDF)
* Immunize.org: Standing Orders for Administering Measles, Mumps, and Rubella Vaccine to Adults ([link removed]) (PDF)
* Immunize.org: Ask the Experts: MMR (Measles, Mumps, and Rubella) ([link removed]) web page
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Journalists interview Immunize.org experts
Journalists seek out Immunize.org experts to help explain vaccines to the public and policy makers. We help the media understand and communicate the complex work vaccinators do. Here is a recent citation.
* NPR: COVID Vaccine Changes Confuse and Upset Some Parents and Families ([link removed]) (6/3/25)
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Vaccines in the news
These recent articles convey the potential risks of vaccine-preventable diseases and the importance of vaccination.
* Washington Post: RFK Jr. Purges Every Vaccine Adviser on CDC Panel; Will Pick Replacements ([link removed]) (6/9/25)
* New York Times: Whooping Cough Is Surging. Do You Need Another Shot? ([link removed]) (6/6/25)
* American Journal of Managed Care: ACP Experts Say FDA, CDC Moves May Undermine COVID-19 Vaccine Coverage for Millions ([link removed]) (6/2/25)
* New York Times: Kennedy Says Healthy Kids Don’t Need COVID Shots. Is That True? ([link removed]) (5/27/25)
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Immunize.org Website and Clinical Resources
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Spotlight on the website: "Ask the Experts" topics and subtopics
This week, we continue highlighting our popular “Ask the Experts ([link removed])” section. This resource provides more than 1,300 practical answers to questions from healthcare professionals about vaccines and vaccine administration. Content is divided into two categories:
* Vaccine Topics—22 specific vaccines
* General Topics—10 vaccination-related categories
Larger topics feature subcategories to assist with your search.
[link removed]
Look at the left navigation menu. If there is a carat (>) next to the topic, click to expand the list of subcategories available. Clicking on a subcategory such as “Vaccine Recommendations” will filter results.
Browse the resulting questions or narrow your results with keyword search (marked 1 in the image above) or by choosing filters (2). Select the “Hide All Answers/Show All Answers” button (3) to hide or expand answer content. In the illustration above, “Hepatitis A,” followed by “Vaccine Recommendations,” and the keyword “Twinrix” produces two results.
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Summary: Updated Immunize.org clinical resources released in April and May
IZ Express regularly provides readers with information about Immunize.org’s new and updated educational materials for healthcare professionals and handouts for patients. All Immunize.org materials are free to distribute.
In case you missed them during recent weeks, updates were made to the following helpful materials.
Immunize.org Updated Materials for Clinicians
Standing Orders Templates: see Top Story above for list.
Materials Supporting Immunization Services:
* Checklist of Current Versions of U.S. COVID-19 Vaccination Guidance and Clinic Support Tools ([link removed])
* Vaccine Storage Quick Reference ([link removed])
* Vaccine Storage Troubleshooting Record ([link removed])
Immunize.org Web Pages:
* Vaccine History Timeline ([link removed])
* New! Website Office Hours: Publication Archives, Vaccine Timeline, & About Us ([link removed])
* New! Website Office Hours: Affiliated Websites ([link removed])
Immunize.org Updated Printable Materials for Your Patients
* Human Papillomavirus (HPV): Questions and Answers ([link removed])
* Human Papillomavirus (HPV): A Parent’s Guide to Preteen and Teen HPV Vaccination ([link removed])
* HPV Vaccine: A Guide for Adults Ages 18–26 Years ([link removed])
Related Links
* Immunize.org: Clinical Resources: Screening Checklists ([link removed]) main page
* Immunize.org: Clinical Resources A–Z ([link removed]) main page to see educational materials sorted by category
* Immunize.org: Ask the Experts ([link removed]) main page to access more than 1,200 questions answered by Immunize.org experts
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Recap: Immunize.org updates “Administering Vaccines: Dose, Route, Site, and Needle Size”
Immunize.org recently updated its clinical resource titled Administering Vaccines: Dose, Route, Site, and Needle Size ([link removed]) to add Penmenvy, the new MenABCWY vaccine from GSK.
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Vaccine Information Statements
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Summary: Spanish and Pohnpeian VIS translations released in April and May
IZ Express provides readers with information about new and updated VISs, translations, and resources. In April, Immunize.org provided updated Spanish translations (PDF and RTF for electronic medical record systems). In May, the Cerro Gordo County Public Health Department generously donated 16 new Pohnpeian VIS translations to post on the website.
The table below contains hyperlinks to the English vaccine VISs, 15 updated Spanish translations, and 16 new Pohnpeian translations.
COVID-19 ([link removed])
COVID-19 ([link removed]) COVID-19 ([link removed])
COVID-19 ([link removed])
Dengue ([link removed])
Dengue ([link removed])
Dengue ([link removed])
Haemophilus influenzae type b (Hib) ([link removed])
Haemophilus influenzae type b (Hib) ([link removed])
Hepatitis A ([link removed]) Hepatitis A ([link removed])
Hepatitis A ([link removed])
Hepatitis B ([link removed])
Hepatitis B ([link removed]) Hepatitis B ([link removed])
Hepatitis B ([link removed])
Influenza, live ([link removed])
Influenza, live ([link removed])
Influenza, live ([link removed])
Influenza, recombinant ([link removed])
Influenza, recombinant ([link removed])
Influenza, recombinant ([link removed])
Influenza, recombinant ([link removed])
Meningococcal ACWY ([link removed])
Meningococcal ACWY ([link removed])
Meningococcal ACWY ([link removed])
Meningococcal B ([link removed])
Meningococcal B ([link removed])
Meningococcal B ([link removed])
Meningococcal B ([link removed])
MMR ([link removed])
MMR ([link removed])
MMR ([link removed])
MMR ([link removed])
MMRV ([link removed])
MMRV ([link removed])
MMRV ([link removed])
MMRV ([link removed])
Multi-vaccine pediatric ([link removed])
Multi-vaccine pediatric ([link removed])
Polio ([link removed])
Polio ([link removed])
Polio ([link removed])
Polio ([link removed])
Pneumococcal conjugate ([link removed])
Pneumococcal conjugate ([link removed])
Rotavirus ([link removed])
Rotavirus ([link removed])
RSV ([link removed])
RSV ([link removed])
RSV ([link removed])
RSV ([link removed])
Smallpox-monkeypox ([link removed])
Smallpox-monkeypox ([link removed])
Smallpox-monkeypox ([link removed])
Smallpox-monkeypox ([link removed])
Td ([link removed])
Td ([link removed])
Tdap ([link removed])
Tdap ([link removed])
Tdap ([link removed])
Varicella ([link removed])
Varicella ([link removed])
Varicella ([link removed])
Varicella ([link removed])
Zoster ([link removed]) Zoster ([link removed])
Immunize.org offers three clinical resources that link to VISs via QR codes:
* QR Code Links to Routinely Recommended Vaccine Information Statements ([link removed])
* QR Code Links to All Vaccine Information Statements ([link removed])
* QR Code Links to Vaccine Information Statement (VIS) Translations: Influenza (Flu) Vaccine (Inactivated or Recombinant) ([link removed])
All these resources appear on our new Clinical Resources topic: VIS-Related Resources ([link removed]).
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Recap: CDC issues two updated VISs for pneumococcal vaccines
On May 29, CDC released updated VISs for pneumococcal polysaccharide vaccine (PPSV23) ([link removed]) and pneumococcal conjugate vaccine (PCV) ([link removed]). Changes incorporate recommendations for the routine use of PCV for adults age 50 years and older (previously 65 years) and the limited use of PPSV23. The updated VISs refer to PCVs generally and no longer reference specific PCV products.
The use of the updated VISs should begin immediately. If you use Immunize.org’s QR code reference resources linking directly to the English VISs ([link removed]) on our website, you can keep using them. These QR code documents automatically link to the updated VISs and ensure you are always accessing the current official version.
Immunize.org will create and post translations of these updated VISs in coming weeks. CDC notes that translated VISs that are out of date following publication of an updated version may continue to be used. The official English VIS must also be provided when providing any translation.
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Featured Resources
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Vaccinate adults! Order laminated 2025 U.S. adult immunization schedule booklets.
Laminated booklets of the 2025 U.S. adult immunization schedule ([link removed]) are still available in the Immunize.org shop. The 2025 child and adolescent schedule booklets sold out.
The schedules are available online as PDFs from CDC ([link removed]) at no cost. Immunize.org’s laminated booklets are ideal for use in any busy healthcare setting where vaccines are given.
Adult Booklets
1 copy: $10.00
2–4 copies: $9.50 each
5–19 copies: $8.50 each
20–99 copies: $7.50 each
100–499 copies: $6.00 each
500–999 copies: $5.00 each
1,000–1,999 copies: $4.00 each
2,000+ copies: $3.25 each
Visit the Shop Immunize.org: Laminated Schedules ([link removed]) web page to view images and order today!
For additional information, call 651-647-9009 or email [email protected].
Related Links
* Immunize.org: Laminated Adult Immunization Schedules (19 and older) ([link removed]) web page
* Immunize.org: Shop Immunize.org ([link removed]) main page
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Help Immunize.org reach more vaccinators through your social media networks. Follow us and share our posts on Facebook, Instagram, and LinkedIn!
Immunize.org offers a social media program to highlight our educational resources for a new audience of vaccinators. Our social media channels now feature our most popular printable resources and Ask the Experts questions, as well as announcements important to frontline vaccinators. Please view and share our newest feature, the Ask the Experts Video Series ([link removed]).
Like, follow, and share Immunize.org’s social media accounts and encourage colleagues and others interested in vaccination to do likewise:
* Facebook at ImmunizeOrg ([link removed])
* Instagram at ImmunizeOrg ([link removed])
* LinkedIn at Immunize.org ([link removed])
* YouTube at ImmunizeOrg ([link removed])
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Notable Publications
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"Trends in County-Level MMR Vaccination Coverage in Children in the United States" published in JAMA
In the June 2 issue, JAMA published Trends in County-Level MMR Vaccination Coverage in Children in the United States ([link removed]). Parts of the research letter appear below.
Childhood vaccination has substantially reduced the incidence of vaccine-preventable diseases and saved countless children’s lives worldwide. The U.S. childhood vaccination program is estimated to have prevented more than 24 million cases of vaccine-preventable diseases in 2019 alone. Nonetheless, there is evidence of a U.S. national-level decline in the childhood measles-mumps-rubella (MMR) vaccination rate between 2019 and 2024. . . .
Our county-level dataset complements the state and national-level CDC data, confirming a widespread decline in MMR vaccination rates in the US after the COVID-19 pandemic while revealing significant heterogeneity in vaccination patterns within and across states. This dataset can be used in spatial and statistical analyses to identify factors associated with low or declining MMR rates in US counties and help inform targeted vaccination strategies to reduce the risk of measles outbreaks.
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Upcoming Events
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Virtual: Register for Immunize.org Website Office Hours. Ask questions and learn about our "News & Updates" web section on June 11 at 4:00 p.m. (ET) or June 12 at 12:00 p.m. (ET). Recorded sessions archived.
To learn simple tips and tricks for using our website efficiently, please register for our next set of Website Office Hours on Wednesday, June 11 at 4:00 p.m. (ET) ([link removed]) or Thursday, June 12 at 12:00 p.m. (ET) ([link removed]). The same content will be covered in both sessions.
We will open each 45-minute session with a short, live demonstration on navigating ourNews & Updates ([link removed]).
Register today for Immunize.org Website Office Hours (content is the same for both):
* Wednesday, June 11 at 4:00 p.m. (ET) ([link removed])
* Thursday, June 12 at 12:00 p.m. (ET) ([link removed])
Th archive of previous Website Office Hours content ([link removed]) is posted at Immunize.org’s "Webinars & Videos" page. These archived programs include Ask the Experts; Clinical Resources; Vaccine Information Statements (VISs); Affiliated Websites; Images, Webinars, Videos, & Social Media; Official Guidance; Publication Archives, Vaccine Timeline, & About Us; Travel Vaccines, Vaccine Confidence, & Addressing Concerns; and Vaccines A–Z.
See our Calendar of Events ([link removed]) for future Immunize.org Website Office Hours.
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Virtual: AIM hosts webinar, “Responding to Measles Outbreaks in High Priority Populations Part II,” on June 17 at 2:00 p.m. (ET)
The Association of Immunization Managers (AIM) will present a 1-hour webinar titled Responding to Measles Outbreaks in High Priority Populations Part II ([link removed]) beginning at 2:00 p.m. (ET) on June 17.
Based on feedback from Part I, this webinar will focus on strategies and engagement with close-knit communities.
Register for the webinar ([link removed]).
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Virtual: NFID hosts webinar, “Protecting Patients Before Travel,” on June 18 at 1:00 p.m. (ET); CE credit offered
NFID ([link removed]) will host a webinar titled Protecting Patients Before Travel ([link removed]) at 1:00 p.m. (ET) on June 18. The panel includes NFID Medical Director Robert H. Hopkins Jr., MD; Chapman University School of Pharmacy Professor Jeffery A. Goad, PharmD, MPH; and ACIP member and Harvard Medical School Associate Professor Lin H. Chen, MD. Speakers will review current recommendations for travelers and share implementation strategies.
CME and CNE credit are available. There is no fee to participate in this activity, but preregistration is required.
Register for the webinar ([link removed]).
NFID hosts monthly webinars ([link removed]) to increase awareness of the importance of infectious disease prevention and treatment. CME, CNE, and CPE credits are available for select recordings. View all archived NFID webinars ([link removed]).
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Virtual: Watch June 25–27 ACIP meeting with discussion of several vaccine recommendations, including COVID-19, HPV, influenza, meningococcal, and RSV
CDC has been scheduled to convene the ACIP ([link removed]) on June 25–27. Recommendation votes are scheduled for COVID-19, HPV, influenza, meningococcal, and RSV vaccines. Additionally, the agenda includes discussion of vaccines targeting anthrax, chikungunya, cytomegalovirus (CMV), Lyme, and pneumococcal diseases.
A recent HHS decision led to the dismissal of all 17 members of ACIP ([link removed]). HHS intends to replace those 17 members with new members currently under consideration ([link removed]) and hold the June 25–27 meeting in Atlanta.
Related Links
* CDC: ACIP main page ([link removed]) for access to webcast, agendas
* CDC: ACIP: Meeting Information ([link removed]) for presentation slides, content from previous meetings, and information about future meetings
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For more upcoming events, visit our Calendar of Events ([link removed]).
Editorial Information
Editor-in-Chief
Kelly L. Moore, MD, MPH
Managing Editor
John D. Gräbenstein, RPh, PhD
Associate Editor
Sharon G. Humiston, MD, MPH
Writer/Publication Coordinator
Taryn Chapman, MS
Courtnay Londo, MA
Style and Copy Editor
Marian Deegan, JD
Web Edition Managers
Arkady Shakhnovich
Jermaine Royes
Contributing Writer
Laurel H. Wood, MPA
Technical Reviewer
Kayla Ohlde
About IZ Express
Immunize.org welcomes redistribution of this issue of IZ Express or selected articles.
When you do so, please add a note that Immunize.org is the source of the material and provide a link to this issue ([link removed]).
IZ Express is supported in part by Grant No. NH23IP922654 from the National Center for Immunization and Respiratory Diseases, CDC. Its contents are solely the responsibility of Immunize.org and do not necessarily represent the official views of CDC.
IZ Express Disclaimer (http:// [link removed])
ISSN: 2771-8085
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- Sender: Immunization Action Coalition
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- Country: United States
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