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How protein-slayer drugs could beat some of the cruellest cancers


Sree VijaykumarMomentum is building for PROTAC treatments that eliminate disease-causing proteins, including those responsible for difficult-to-treat childhood cancers.

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Can Supercapacitors Save the Grid from AI's Power Spikes?
Can Supercapacitors Save the Grid from AI's Power Spikes?
In the United Kingdom, electricity provider National Grid faces a problem every time there is a soccer match on (or any other widely viewed televised event, for that matter): During halftime, or a commercial break, an inordinate number of viewers go to turn on their tea kettles. This highly British coordinated activity strains the energy grid, causing spikes in demand of sometimes thousands of megawatts.


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Shippers are skeptical of Trumps truce with the Houthis - WSJ (No paywall)
Shippers are skeptical of Trumps truce with the Houthis
The top five container-shipping companies said they were assessing the deal announced Tuesday by President Trump but had no immediate plans to return to the area where the Houthis began targeting merchant ships in late 2023 in response to the war in the Gaza Strip.


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When Youre Asked to Meet Impossible Goals - Harvard Business Review (No paywall)
When Youre Asked to Meet Impossible Goals
John, the CRO of a private equity-backed tech company, faced mounting pressure to meet sky-high sales targets tied to an acquisition. He knew the goals he was given were unachievable. Saying yes risked burnout and failure; saying no risked his credibility.


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The Huge, Under-the-Radar Shift Happening in the West Bank
The Huge, Under-the-Radar Shift Happening in the West Bank
Over the past few months, an Israeli military operation has displaced tens of thousands of Palestinians in West Bank cities. Some Palestinians fear it may be laying the ground to annex the territory.






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White House withdraws nomination of a former Fox News contributor for U.S. surgeon general - STAT (No paywall)
White House withdraws nomination of a former Fox News contributor for U.S. surgeon general
WASHINGTON The White House is withdrawing the nomination of former Fox News medical contributorJanette Nesheiwatfor U.S. surgeon general, marking at least the second health-related pick from PresidentDonald Trumpto be pulled from Senate consideration.


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Brad Arnold, frontman with rock band 3 Doors Down, diagnosed with stage four cancer
Brad Arnold, frontman with rock band 3 Doors Down, diagnosed with stage four cancer
3 Doors Down performed at the Make America Great Again! Welcome Celebration, a concert to mark Donald Trump’s 2017 inauguration as president. After criticism in some quarters, guitarist Chris Henderson defended their performance, saying: “It wasn’t a Trump thing … It was the inauguration of a president of the United States of America. This is history-making stuff. It’s a one-in-a-lifetime chance to do something for your country.”


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Alphabet shares slide as Apple seeks AI alternatives to Google search - FT (No paywall)
Alphabet shares slide as Apple seeks AI alternatives to Google search
Senior executive says tech group is looking at start-up options for iPhone and Safari browser


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Rubio Threatens Visa Revocations After Pro-Palestinian Protests At Columbia - Forbes (No paywall)
Rubio Threatens Visa Revocations After Pro-Palestinian Protests At Columbia
Police arrested dozens of pro-Palestinian protestors at Columbia University on Wednesday evening after they took over a part of the schools main library, as Secretary of State Marco Rubio threatened a crackdown on any foreign nationals who participated in the protest.




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China Is Likely to Play Hardball in U.S. Tariff Talks
China Is Likely to Play Hardball in U.S. Tariff Talks
Beijing says it will meet with American officials to discuss trade, but warned Washington against using the engagement to ratchet up pressure on China.


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April storms that killed 24 in US made more severe by burning fossil fuels study
April storms that killed 24 in US made more severe by burning fossil fuels  study
This is the 101st WWA study, a decade-old initiative that provides rapid scientific analysis on whether and to what extent human-induced global heating driven by burning fossil fuels and deforestation has altered the likelihood and intensity of a local extreme weather event. The latest study was conducted by 15 researchers as part of the World Weather Attribution group, including scientists from universities and meteorological agencies in the US, UK, France and Netherlands.


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A Salacious Saga Engulfs the Virginia G.O.P. and Weakens Youngkin
A Salacious Saga Engulfs the Virginia G.O.P. and Weakens Youngkin
Gov. Glenn Youngkin’s failure to push out the Republican nominee for lieutenant governor over a scandal involving explicit photos showed the party’s divisions and the power of its right-wing base.


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How the US Built 5,000 Ships in WWII
How the US Built 5,000 Ships in WWII
Among the most impressive manufacturing achievements of the US during WWII was the number of ships it produced. Prior to the war, the American shipbuilding industry had been moribund. Shipyards had been busy during and immediately following WWI, but the huge flood of wartime ships greatly reduced demand for new ones, and American shipyards didn’t produce a single oceangoing hull between 1922 and 1928. The onset of the Great Depression only made things worse, and by 1935 annual tonnage produced by US commercial shipbuilders had fallen to its lowest level in more than 100 years.




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Hedge Funds $30 Million Pay Shows Race for Japan Rates Traders - Bloomberg (No paywall)
Hedge Funds $30 Million Pay Shows Race for Japan Rates Traders
A talent war is intensifying in the yen rates space, as banks and hedge funds snap up seasoned traders after the biggest market swings in years inflicted widespread losses.


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The Vatican financial mess Pope Francis couldnt fix - WSJ (No paywall)
The Vatican financial mess Pope Francis couldnt fix
The ailing pope was short of breath, sitting beneath a cherished painting of Mary, Untier of Knots, as he worked through a last-ditch plan to disentangle the finances of one of the worlds most opaque bureaucracies.


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Chinas Xi Jinping Travels to Russia for Victory Day - Foreign Policy (No paywall)
Chinas Xi Jinping Travels to Russia for Victory Day
World Brief: Chinas Xi Jinping Travels to Russia for Victory Day


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Voice of America to Receive Feeds From Pro-Trump Network, Administration Says
Voice of America to Receive Feeds From Pro-Trump Network, Administration Says
Kari Lake, whom President Trump put in charge of overhauling Voice of America, said the broadcaster would be fed with content from One America News Network.




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Private Equity Shoves Angry Lenders to the Back of the Line - Bloomberg (No paywall)
Private Equity Shoves Angry Lenders to the Back of the Line
A stampede of restructuring companies is creating a class system that's costing creditors billions. Its a new blow for debt investors just as the economy needs them most.


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Yemen's Houthis say attacks on Israel not in ceasefire deal in 'any way'
Yemen's Houthis say attacks on Israel not in ceasefire deal in 'any way'
Mohammed Abdulsalam told the Reuters news agency on Wednesday that attacking Israel was not included in "any way, shape or form" in the agreement mediated by Oman. The announcement of the deal came hours after Israeli warplanes targeted Yemen's Sanaa airport.


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AI data startup WisdomAI nabs $23M with a smart way to avoid hallucinations
AI data startup WisdomAI nabs $23M with a smart way to avoid hallucinations
Rubrik co-founder Soham Mazumdar, who left in 2023, has a new data startup called WisdomAI. The company offers AI data analytics that can deliver business insights with structured, unstructured, and even "dirty" data, meaning data not cleaned of typos or errors.


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Opinion | No One Has Ever Defeated Autocracy From the Sidelines
Opinion | No One Has Ever Defeated Autocracy From the Sidelines
And how exactly can we tell whether America has crossed the line?




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Xi's Visit to Russia Complicates China's Courtship of Europe
Xi's Visit to Russia Complicates China's Courtship of Europe
As Donald J. Trump has injected chaos into the world by roiling America's alliances and threatening economic turmoil with his wall of tariffs, China has tried to sell a consistent message: We will be a force of global stability during a turbulent time.


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This patient's Neuralink brain implant gets a boost from generative AI
This patient's Neuralink brain implant gets a boost from generative AI
Last November, Bradford G. Smith got a brain implant from Elon Musk's company Neuralink. The device, a set of thin wires attached to a computer about the thickness of a few quarters that sits in his skull, lets him use his thoughts to move a computer pointer on a screen.


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This Founder Just Launched an AI Clone of Himself. Should You? - Inc (No paywall)
This Founder Just Launched an AI Clone of Himself. Should You?
Entrepreneurs are in a constant, never-ending battle with time. Between managing direct reports, training new employees, and growing the business, it can feel like there arent enough hours in the day to get everything done. But what if you could offload some of that work to someone you trust implicitly: a version of yourself?


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Trumps latest deportation scheme is almost certainly illegal
Trumps latest deportation scheme is almost certainly illegal
In a world with too much noise and too little context, Vox helps you make sense of the news. We dont flood you with panic-inducing headlines or race to be first. We focus on being useful to you breaking down the news in ways that inform, not overwhelm.




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Know Your Enemy: How Three Years at McKinsey Shaped My Second Startup
"If you know the enemy and know yourself, you need not fear the result of a hundred battles. If you know yourself but not the enemy, for every victory gained you will also suffer a defeat. If you know neither the enemy nor yourself, you will succumb in every battle."


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Americas self-defeating AI export controls - WSJ (No paywall)
Americas self-defeating AI export controls
Americas response to Chinas rise in semiconductors and artificial intelligence has been reactive, timid and structurally unserious. The U.S. is forfeiting a long-term strategic advantage.


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Macron calls on US, Europe to lift sanctions on Syria
Macron calls on US, Europe to lift sanctions on Syria
Al-Sharaa, a former Al Qaeda member, has received a cautious welcome from the international community after his forces toppled brutal Syrian dictator Bashar Assad late last year. He has vowed to protect minority groups in Syria and to pursue more inclusive policies.


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Ultraprocessed Foods Linked to Early Symptoms of Parkinson's
Ultraprocessed Foods Linked to Early Symptoms of Parkinson's
Over the last decade, researchers have found associations between ultraprocessed foods and health conditions like heart disease, Type 2 diabetes, dementia and some types of cancer. Now, they are adding Parkinson's disease to that list.




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The Aristocrat Diet: Why Do Posh People Eat Such Beige, Bland, Boring Food?
The Aristocrat Diet: Why Do Posh People Eat Such Beige, Bland, Boring Food?
They like ice-cream - but only homemade. Carrots - but only served whole. And don't even think of cooking with any herb or spice livelier than parsley ...


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Whistleblowers who defied Credit Suisse are about to share up to $150 million - WSJ (No paywall)
Whistleblowers who defied Credit Suisse are about to share up to $150 million
A Credit Suisse unit this week pleaded guilty again to helping Americans hide their assets to evade taxes and agreed to pay $511 million for not meeting the terms of a 2014 settlement with U.S. authorities. Credit Suisse is now owned by UBS after an emergency 2023 rescue.


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Chinese cyber menace exceeds threat from Russia, Dutch spy chiefwarns
Chinese cyber menace exceeds threat from Russia, Dutch spy chiefwarns
China has a very complex, organized cyber system. And we are not able to have a full grasp on what they can do, Vice Adm. Peter Reesink, director of Dutch military intelligence agency MIVD, told POLITICO during an interview. I would say that it's more threatening than Russia.


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Live Updates: Papal Conclave Enters 2nd Day
Live Updates: Papal Conclave Enters 2nd Day
When it comes to the conclave to elect the next pope, the waiting is the hardest part. The 133 cardinals tasked with picking the new leader of the Roman Catholic Church and 1.




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How Lost Radar and Silent Radios Have Upended Newark Air Travel
How Lost Radar and Silent Radios Have Upended Newark Air Travel
A technical outage in Philadelphia last week terrified air traffic controllers and stranded passengers. As the summer travel season looms, the F.A.A. is racing to address the problems.


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Canada's F-35 nightmare
Canada's F-35 nightmare
Ellie Cook is a Newsweek security and defense reporter based in London, U.K. Her work focuses largely on the Russia-Ukraine war, the U.S. military, weapons systems and emerging technology. She joined Newsweek in January 2023, having previously worked as a reporter at the Daily Express, and is a graduate of International Journalism at City, University of London. Languages: English, Spanish.You can reach Ellie via email at [email protected].


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Genetic Study Retraces the Origins of Coronaviruses in Bats
Genetic Study Retraces the Origins of Coronaviruses in Bats
In the early 2000s, a coronavirus infecting bats jumped into raccoon dogs and other wild mammals in southwestern China. Some of those animals were sold in markets, where the coronavirus jumped again, into humans. The result was the SARS pandemic, which spread to 33 countries and claimed 774 lives.


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Vagus Nerve Stimulation Erases PTSD - Neuroscience News
Vagus Nerve Stimulation Erases PTSD - Neuroscience News
Summary: A pioneering clinical study found that pairing vagus nerve stimulation (VNS) with traditional therapy eliminated PTSD diagnoses in all participants up to six months post-treatment. The trial combined prolonged exposure therapy with brief bursts of VNS via an implanted device, enhancing neuroplasticity and sustaining remission.




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Why Peace Talks Fail in Ukraine - Foreign Affairs (No paywall)
Why Peace Talks Fail in Ukraine
Since its founding in 1922, Foreign Affairs has been the leading forum for serious discussion of American foreign policy and global affairs. The magazine has featured contributions from many leading international affairs experts.


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Smokey Robinson's Lawyer Slams 'Vile' and 'False' Sexual Assault Claims
Smokey Robinson's Lawyer Slams 'Vile' and 'False' Sexual Assault Claims
Four women have accused the Motown legend of sexually assaulting them while they worked as housekeepers.


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Samsung is paying $350 million for audio brands Bowers & Wilkins, Denon, Marantz and Polk
Samsung is paying $350 million for audio brands Bowers & Wilkins, Denon, Marantz and Polk
Harman International, a wholly owned subsidiary of Samsung, is purchasing the audio business of health technology company Masimo for $350 million in cash. The deal is expected to finalized by the end of 2025, though it's still subject to regulatory approvals. Samsung purchased Harman International back in 2017 for $8 billion, though it allowed the company to operate as an independent subsidiary. Harman's brands include JBL, Harman Kardon, AKG, Mark Levinson, Arcam and Revel. If and when the acquisition pushes through, Masimo's audio brands under Sound United will be added to the list, including Bowers & Wilkins, Denon, Marantz and Polk Audio.


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A Snake Collector Volunteered for 200 Snakebites. His Blood Is Now Being Studied in Antivenom - Scientific American (No paywall)
A Snake Collector Volunteered for 200 Snakebites. His Blood Is Now Being Studied in Antivenom
Scientists have made a potent antivenom using antibodies from a man who has been bitten hundreds of times by venomous snakes. The therapy protects mice against the venoms of 19 species of deadly snake, including the king cobra (Ophiophagus hannah).




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Efforts Grow to Thwart mRNA Therapies as RFK Jr. Pushes Vaccine Wariness
Efforts Grow to Thwart mRNA Therapies as RFK Jr. Pushes Vaccine Wariness
Therapies involving mRNA, a key to Covid vaccines, hold great potential in treating several diseases, but some lawmakers want to ban them and the government is cutting funding.


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National Archives Releases More Robert F. Kennedy Files
National Archives Releases More Robert F. Kennedy Files
The new batch of documents included transcripts of police interviews with Sirhan Sirhan, who was convicted of killing Mr. Kennedy.


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Congress Grills College Presidents with an Old Script and New Threats
Congress Grills College Presidents with an Old Script and New Threats
In a House hearing, lawmakers scrutinized a set of college leaders from institutions outside the Ivy League schools that have drawn the Trump administration’s attention.




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Trump Has Made Claims About Abrego Garcia's Tattoos. Here's a Closer Look.
Trump Has Made Claims About Abrego Garcia's Tattoos. Here's a Closer Look.
Gang experts say the tattoos on Kilmar Abrego Garcia’s knuckles are unlikely to signify gang membership. The president says otherwise.


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Federal Judge Casts Doubt on Trump Arguments in Venezuelan Migrants Case
Federal Judge Casts Doubt on Trump Arguments in Venezuelan Migrants Case
The judge pressed a lawyer for the Justice Department on the government’s role and responsibilities in the men’s deportation and incarceration in El Salvador.


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What's at Stake in the Conclave? The Keys of the Kingdom of Heaven.
What's at Stake in the Conclave? The Keys of the Kingdom of Heaven.
The Gospel of Matthew inspired an enduring Christian symbol: Jesus passing the keys to Peter. Cardinals are now choosing who will hold the keys — and their power — next.


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Courts Must 'Check the Excesses' of Congress and the President, Roberts Says
Courts Must 'Check the Excesses' of Congress and the President, Roberts Says
The chief justice, in rare public remarks, defended judicial independence before a crowd of lawyers and judges.


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He Faced a Possible Prison Term for Assault. Instead, He Was Deported.
He Faced a Possible Prison Term for Assault. Instead, He Was Deported.
Federal agents are rounding up criminal defendants and deporting them before trial. Local prosecutors say the disruptions make communities less safe.


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Is Japanese anime the next global IP gold mine? - FT (No paywall)
Is Japanese anime the next global IP gold mine?
Japans distinctive cartoons are attracting worldwide audiences, Hollywood studios and private equity companies alike. Who will reap the rewards?




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