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Issue 1,809: April 16, 2025
Top Stories
* HPV vaccination is powerful cancer prevention: three Immunize.org patient handouts on HPV updated with case counts and corrected CDC URLs
* PBS and YouTube offer free streaming of documentary titled Virulent: The Vaccine War
* Measles marches on; 712 confirmed measles cases reported in 24 states, including two new states since last week
* National Infant Immunization Week is April 21–28; jump start promotion activities with Vaccinate Your Family’s NIIW resources
* Our last weekly influenza season update as influenza lingers; 188 children have died so far
* Get up to speed on how to navigate our clinical resources on your smartphone in 3 minutes or less with Immunize.org’s Orientation Video Series: "Introducing Clinical Resources" (mobile view)
* Vaccines in the news
Immunize.org Website and Clinical Resources
* Spotlight on the website: "Calendar of Events"
* Recap: Immunize.org updates references in five vaccine standing orders templates for infants, children, and adults
Vaccine Information Statements
* Recap: Immunize.org posts Spanish translations of 17 recently updated VISs
Featured Resources
* Medscape offers CDC educational activity on measles; CE credit available
* Almost out of childhood schedules! Order laminated 2025 U.S. immunization schedule booklets from Immunize.org.
* Updated 65+ Flu Defense website offers resources for healthcare professionals serving older adults
* Assessing adults for vaccine needs? Use Immunize.org’s Vaccinating Adults: A Step-by-Step Guide—free to download
Notable Publications
* "Strategies for Communicating with Parents About Vaccines" published in JAMA
* "Approaches for MMR Vaccination During a Measles Outbreak and Evolving Domestic Attitudes" published in JAMA
Upcoming Events
* Today. Virtual: Watch April 16 ACIP meeting conclude with votes on chikungunya, MenABCWY, and RSV recommendations.
* Virtual: North Dakota State University hosts webinar titled “Pediatric Vaccine Conversations: Addressing Common Concerns” on April 23 at 1:00 p.m. (ET); CME credit available
* Virtual: Register for Immunize.org Website Office Hours. Ask your questions and learn about our affiliated websites on May 7 at 4:00 p.m. ET or May 8 at 12:00 p.m. ET. Previously recorded sessions available online.
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Top Stories
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HPV vaccination is powerful cancer prevention: three Immunize.org patient handouts on HPV updated with case counts and corrected CDC URLs
With all the talk about measles and influenza, it can be easy to overlook other important childhood vaccinations. Immunize.org offers several resources to help you educate families and adults about HPV vaccination and its critical role in cancer prevention. Immunize.org recently updated three of its patient handouts on HPV with current HPV-associated cancer case counts and updated reference URLs:
* Human Papillomavirus (HPV): A Parent's Guide to Preteen and Teen HPV Vaccination ([link removed])
* HPV Vaccine: A Guide for Adults Ages 18–26 Years ([link removed])
* Human Papillomavirus (HPV): Questions and Answers ([link removed])
Related Links
* Immunize.org: Vaccines A–Z: HPV (Human Papillomavirus) ([link removed]) main page
* Immunize.org: Clinical Resources A–Z ([link removed]) main page, where you can filter by topic, vaccine, language, or other criteria
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PBS and YouTube offer free streaming of documentary titled Virulent: The Vaccine War
Virulent: The Vaccine War, a documentary exploring vaccine hesitancy, can now be streamed, free of charge ([link removed]), on YouTube ([link removed]). Thanks to the Public Broadcasting System (PBS), it is also available through the PBS website and the free PBS app. The PBS app functions on iPhone, Apple TV, Android TV, Android smartphones, Amazon Fire TV, Amazon Fire Tablet, Roku, Samsung Smart TV, and Vizio. The PBS description of the documentary appears below.
[Virulent: The Vaccine War] examines the consequences of vaccine denial & hesitancy which the World Health Organization calls one of the top 10 threats to global health. It cuts across political, cultural, racial and socio-economic lines. It’s a war anti-vax activists . . . have been fighting for years. And COVID-19 is what they practiced for: A national conversation about vaccine safety & mandates.
Deepen your understanding of the challenging issues faced by vaccination providers and public health professionals every day. Stream the 86-minute documentary at pbs.org/show/virulent-the-vaccine-war ([link removed]), request a screening ([link removed]), or watch it on YouTube ([link removed]).
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Measles marches on; 712 confirmed measles cases reported in 24 states, including two new states since last week
In its April 10 weekly update, CDC reported 712 confirmed measles cases ([link removed]) in 2025, with 93% of the cases associated with seven outbreaks. Indiana and Arkansas both reported cases since the last weekly update. Most reported cases (541 of 712, 76%) were reported by the Texas Department of State Health Services ([link removed]). To date, three people have died, including the confirmed measles deaths of two otherwise healthy unvaccinated children in Texas, age 6 and 8 years, and one unvaccinated adult in New Mexico who was infected with measles but did not seek medical attention before dying. The adult’s cause of death is under investigation.
A map of 2025 measles cases, as of April 10, is shown below.
[link removed]
On April 8, CDC issued updated measles guidance to healthcare providers ([link removed]), urging them to stay alert for measles cases. The CDC notice reminds healthcare professionals of four basic steps to take when a measles case is suspected:
* Isolate your patient with suspected measles immediately
* Immediately notify public health
* Collect samples
* Manage patients with supportive care, being careful to avoid overuse of vitamin A, which can cause toxicity or birth defects if given during pregnancy
For the details of each step, see the April 8 CDC web page: Healthcare Providers: Stay Alert for Measles Cases ([link removed]).
Related Links
* CDC: Measles Cases and Outbreaks ([link removed]) main page
* CDC: Public Health Preparedness Checklist: Measles Clusters and Outbreaks ([link removed]) (PDF)
* Immunize.org: Vaccines A–Z: Measles ([link removed]) main page
* Immunize.org: Standing Orders for Administering Measles, Mumps, and Rubella Vaccine to Children and Teens ([link removed]) (PDF)
* Immunize.org: Standing Orders for Administering Measles, Mumps, and Rubella Vaccine to Adults ([link removed]) (PDF)
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National Infant Immunization Week is April 21–28; jump start promotion activities with Vaccinate Your Family’s NIIW resources
National Infant Immunization Week (NIIW) ([link removed]), April 21–28, highlights the importance of protecting infants from vaccine-preventable diseases and celebrates the achievements of immunization partners. Since 1994, hundreds of communities have joined together during NIIW to highlight the crucial role vaccination plays in protecting our children, communities, and public health.
CDC, the American Academy of Pediatrics, and the American Academy of Family Physicians recommend that children stay on track with their well-child appointments and routine vaccinations. Completing the recommended vaccinations by age 2 years is the best way to protect young children from 15 potentially life-threatening diseases. In light of the recent measles outbreaks, these messages are more important than ever.
Relevant resources are available from Vaccinate Your Family (VYF) ([link removed]). VYF’s #VaxToTheFuture campaign is a bilingual initiative to remind parents, caregivers, and communities of a simple but powerful truth: a childhood free from vaccine-preventable diseases is possible — but only if we remember the lessons of the past and choose to vaccinate.
CDC resources cited in last week’s edition of IZ Express are no longer posted online. CDC continues to offer NIIW logos in various languages and formats.
Related Links
* CDC: National Infant Immunization Week (NIIW) ([link removed]) main page
* CDC: Routine Immunizations on Schedule for Everyone (RISE) ([link removed]) main page
* VYF: National Infant Immunization Week 2025 ([link removed]) main page
* Immunize.org: Parent Handouts ([link removed]) main page
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Our last weekly influenza season update as influenza lingers; 188 children have died so far
As the prevalence of influenza-like illness finally dips below the epidemic threshold, this article will be the final routine IZ Express weekly influenza season update, barring a late-season influenza resurgence. For week 14, ending April 5, CDC’s Weekly Influenza Surveillance Report, FluView ([link removed]), reports that five jurisdictions showed influenza-like illness activity at moderate levels. CDC classified the 2024–25 season as a high-severity season for people of all ages, with the highest hospitalization rate recorded since the 2010–11 season. During week 14, 2.5% of outpatient visits involved influenza-like illness, which is below the epidemic threshold of 3.0% after 18 weeks of sustained activity above the epidemic threshold. Twenty pediatric deaths associated with seasonal influenza virus infection were reported during week 14, bringing the 2024–25 season total to 188 childhood deaths so far.
CDC and medical societies recommend that children age 6 months through 8 years ([link removed]) receive two doses of influenza vaccine during the first season they are vaccinated against influenza to help them mount an effective immune response to a single influenza vaccination in future seasons. Continue offering influenza vaccination to children who need two doses but have had only one so far this season.
Related Links
* CDC: Weekly National Flu Vaccination Dashboard ([link removed]) main page
* CDC: FluView ([link removed]) main page
* CDC: RESP-NET ([link removed]) main page
* Immunize.org: Vaccines A–Z: Influenza ([link removed]) main page
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Get up to speed on how to navigate our clinical resources on your smartphone in 3 minutes or less with Immunize.org’s Orientation Video Series: "Introducing Clinical Resources" (mobile view)
Learn how to navigate Immunize.org’s clinical resources to find just what you need on your smartphone. Check out the “mobile view” version of our 3-minute Orientation Video Series: ([link removed]) Introducing Clinical Resources ([link removed]).
Available on our YouTube channel ([link removed]), this is part of our Orientation Video Series ([link removed]).
Share these videos with anyone who would like to learn more about Immunize.org’s website to support effective immunization practices.
* Immunize.org: Webinars & Videos Orientation Video Series ([link removed]) page
* Facebook at ImmunizeOrg ([link removed])
* Instagram at ImmunizeOrg ([link removed])
* LinkedIn at ImmunizeOrg ([link removed])
* YouTube at ImmunizeOrg ([link removed])
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Vaccines in the news
These recent articles convey the potential risks of vaccine-preventable diseases and the importance of vaccination.
* Council on Foreign Relations: How Vaccines Changed the World ([link removed]) (4/9/25)
* Nature: 154 Million Lives and Counting: 5 Charts Reveal the Power of Vaccines ([link removed]) (4/8/25)
* Philadelphia Inquirer: I Put the ‘R’ in the MMR Vaccine, and I’m Scared That, Like Measles, Rubella Could Make a Comeback Under RFK Jr. ([link removed]) (4/7/25)
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Immunize.org Website and Clinical Resources
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Spotlight on the website: "Calendar of Events"
The Immunize.org Calendar of Events ([link removed]) lists upcoming vaccination-related events of national or regional importance, including conferences and ACIP meetings. There are two ways to access it.
From the Immunize.org home page ([link removed]): Scroll to the bottom, where you see “Upcoming Events.” See more by clicking the “See all Events” button.
From the “News & Updates” tab on each web page: on the left side, click on Calendar of Events ([link removed]).
Select the “More Information” button for any event to view additional details.
If you are planning an event lasting at least half a day that may interest members of the national immunization community, send a suggestion for the calendar by submitting a Contact Us ([link removed]) message from our website.
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Recap: Immunize.org updates references in five vaccine standing orders templates for infants, children, and adults
Immunize.org updated the references on five standing orders templates for infants, children, and adults to remove the reference to Appendix B ([link removed]) in the Epidemiology and Prevention of Vaccine-Preventable Diseases (the "Pink Book"). The updated standing order templates include:
* Standing Orders for Administering Inactivated Poliovirus Vaccine to Infants and Children ([link removed])
* Standing Orders for Administering Diphtheria, Tetanus, and Acellular Pertussis (DTaP) Vaccine to Children Younger Than Age 7 Years ([link removed])
* Standing Orders for Administering Td/Tdap Vaccine to Adults ([link removed])
* Standing Orders for Administering Tdap/Td Vaccine to Children and Teens Age 7 Years and Older ([link removed])
* Standing Orders for Administering Tdap During Pregnancy ([link removed])
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Vaccine Information Statements
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Recap: Immunize.org posts Spanish translations of 17 recently updated VISs
Immunize.org updated Spanish translations of 17 VISs to correspond with CDC's recently posted revisions, dated January 31, 2025. The revisions comply with a January 20, 2025, presidential executive order. Changes were limited to replacing the words “persons,” “person,” and “they” with the words "women," "woman," and "she" when referring to pregnancy or breastfeeding.
COVID-19 ([link removed])
COVID-19 ([link removed]) COVID-19 ([link removed])
Dengue ([link removed])
Dengue ([link removed])
Dengue ([link removed])
Hepatitis A ([link removed])
Hepatitis A ([link removed]) Hepatitis A ([link removed])
Hepatitis B ([link removed])
Hepatitis B ([link removed])
Hepatitis B ([link removed])
Influenza, live ([link removed])
Influenza, live ([link removed]) Influenza, live ([link removed])
Influenza, recombinant ([link removed])
Influenza, recombinant ([link removed])
Influenza, recombinant ([link removed])
MMR ([link removed])
MMR ([link removed])
MMR ([link removed])
MMRV ([link removed])
MMRV ([link removed])
MMRV ([link removed])
Meningococcal ACWY ([link removed])
Meningococcal ACWY ([link removed])
Meningococcal ACWY ([link removed])
Meningococcal B ([link removed])
Meningococcal B ([link removed])
Meningococcal B ([link removed])
Polio ([link removed])
Polio ([link removed])
Polio ([link removed])
RSV ([link removed])
RSV ([link removed])
RSV ([link removed])
Smallpox/monkeypox ([link removed])
Smallpox/monkeypox ([link removed])
Smallpox/monkeypox ([link removed])
Tdap ([link removed])
Tdap ([link removed])
Tdap ([link removed])
Varicella ([link removed])
Varicella ([link removed])
Varicella ([link removed])
When given any VIS translation, the patient should also receive the current VIS in English. You Must Provide Patients with Vaccine Information Statements (VISs) – It’s Federal Law! ([link removed]) offers additional tips on using VISs.
To locate all available VISs and clinical resources in a given language, visit our translations home page ([link removed]).
Check the version dates of your inventory of VIS translations at regular intervals. Discard translations of previous versions as updated translations of current versions become available. Due to the minimal content changes, Immunize.org is not updating other VIS translations at this time.
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Featured Resources
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Medscape offers CDC educational activity on measles; CE credit available
Medscape released a text-based educational activity for healthcare professionals: Medscape Now! Hot Topics in Pediatrics Edition 1 ([link removed]). The "Would You Be Able to Identify Measles in a Patient?" section discusses the signs of measles and what to do if you see them in a patient.
To view the activity and earn 0.25 hours of CME and other credits towards requirements for various health professions, click here ([link removed]).
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Almost out of childhood schedules! Order laminated 2025 U.S. immunization schedule booklets from Immunize.org.
Laminated booklets of the 2025 U.S. child and adolescent immunization schedule ([link removed]) and the 2025 U.S. adult immunization schedule ([link removed]) are available now in the Immunize.org shop.
The schedules are available online as PDFs from CDC ([link removed]) at no cost. Immunize.org’s laminated booklets are ideal for use in any busy healthcare setting where vaccines are given. Features include:
* Durability: Their tough coating can be wiped down, and they can stand up to a year's worth of use.
* Format: Each schedule is produced in an 8.5” X 11” booklet format; with color coding for easy reading, our laminated schedules replicate the original CDC formatting, including all tables and notes. The adult schedule is 16 pages and the child and adolescent schedule is 20 pages.
* Easy access to CDC updates: The CDC online schedule includes an addendum page that will display ACIP’s new recommendations as CDC adopts them during 2025. Each Immunize.org laminated schedule addendum page includes QR codes you can scan to view or print the online addendum page as it is revised.
* Bonus content: Both schedules include a bonus page with Immunize.org’s popular 1-page handout summarizing the dose, route, and needle size recommendations for all vaccines and recipients.
Pricing:
Child and Adolescent Booklets Adult Booklets
1 copy: $10.50 1 copy: $10.00
2–4 copies: $10.00 each 2–4 copies: $9.50 each
5–19 copies: $9.00 each 5–19 copies: $8.50 each
20–99 copies: $8.00 each 20–99 copies: $7.50 each
100–499 copies: $6.50 each 100–499 copies: $6.00 each
500–999 copies: $5.50 each 500–999 copies: $5.00 each
1,000–1,999 copies: $4.50 each 1,000–1,999 copies: $4.00 each
2,000+ copies: $3.75 each 2,000+ copies: $3.25 each
Visit the Shop Immunize.org: Laminated Schedules ([link removed]) web page to view images and order today!
For additional information, call 651-647-9009 or email
[email protected].
Related Links
* Immunize.org: Laminated Child and Adolescent Immunization Schedules (0–18 years) ([link removed]) web page
* Immunize.org: Laminated Adult Immunization Schedules (19 and older) ([link removed]) web page
* Immunize.org: Shop Immunize.org ([link removed]) main page
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Updated 65+ Flu Defense website offers resources for healthcare professionals serving older adults
Confident healthcare provider recommendations for influenza vaccine are powerfully persuasive. This influenza season has been a tough one. To help you maximize patient protection, Immunize.org, in collaboration with CSL Seqirus, updated the 65+ Flu Defense ([link removed]) website.
This helpful site includes information, tools, and tips for communicating with adults age 65 and older about the scope and severity of influenza. Resources include:
* Influenza in Adults 65+: The Facts ([link removed])
* Influenza Vaccination: Questions Patients Aged 65 and Older Frequently Ask Their HCP ([link removed])
* The Importance of Preventing Influenza and COVID-19 ([link removed])
Older adults are at increased risk of severe influenza, COVID-19, and RSV illness, including hospitalization and death, especially if they are not up to date on these vaccinations. A clinician recommendation is the most important reason why a patient will get vaccinated.
Check out the updated 65+ Flu Defense ([link removed]) website to assist your ongoing efforts in protecting this vulnerable population.
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Assessing adults for vaccine needs? Use Immunize.org’s Vaccinating Adults: A Step-by-Step Guide—free to download
Download Immunize.org’s free 142-page book on adult vaccination to help build your program and train your team: Vaccinating Adults: A Step-by-Step Guide (Guide) ([link removed]).
This thorough "how to" guide on adult vaccination provides easy-to-use, practical information covering all essential activities. It helps vaccine providers enhance their existing adult vaccination services or introduce them into any clinical setting.
The Guide ([link removed]) is available to download/print either by chapter or in its entirety free of charge. The National Vaccine Program Office and CDC both supported the development of the Guide and provided early technical review.
The Guide is a valuable resource to assist providers in increasing adult vaccination rates. Be sure to get a copy today!
Please note: this guide was produced in 2017, before the COVID-19 era, and reflects the recommendations of that time.
Related Links
* Vaccinating Adults: A Step-by-Step Guide ([link removed]) main page, permitting download of entire Guide (142 pages, PDF) ([link removed])
* View the table of contents and individual chapters (PDF):
+ Table of Contents ([link removed])
+ Step 1: Getting Started ([link removed])
+ Step 2: Setting Up for Vaccination Services ([link removed])
+ Step 3: Vaccine Storage and Handling ([link removed])
+ Step 4: Deciding Whom to Vaccinate ([link removed])
+ Step 5: Administering Vaccines ([link removed])
+ Step 6: Documentation and Related Issues ([link removed])
+ Step 7A: Financial Considerations ([link removed])
+ Step 7B: How to Bill for Adult Immunizations ([link removed])
* Immunize.org’s Clinical Resources on adult immunization ([link removed])
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Notable Publications
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"Strategies for Communicating with Parents About Vaccines" published in JAMA
In the April 9 issue, JAMA published Strategies for Communicating with Parents About Vaccines ([link removed]). The article’s table, "Strategies for Discussions of Vaccination with Patients," appears below. The article contains additional detail about each of these communication approaches (strategy, example).
Shared goals: "You and I have a shared goal of trying to do what is best for your child."
Presumptive approach: "Johnny is due for three vaccines today."
Social norms: "Almost all of my patients have gotten this vaccine."
Permission to share: "This question has come up for me a few times, so I looked into it. Would it be okay if I go over what I found out for you?"
Prebunking: "You should be careful about what you see on the internet about vaccines because there is a lot of inaccurate information. I can recommend some sources that I trust if you have questions."
Values-based messaging: "One way of thinking about making the decision to vaccinate your child is that, similar to encouraging them to be active and eat healthy foods, it is a decision to help them thrive and grow into a healthy adult."
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"Approaches for MMR Vaccination During a Measles Outbreak and Evolving Domestic Attitudes" published in JAMA
In the April 9 issue, JAMA published Approaches for MMR Vaccination During a Measles Outbreak and Evolving Domestic Attitudes ([link removed]) by Kathryn M. Edwards, MD. A portion of the commentary appears below.
When CDC guidance is slow or incomplete, infectious disease specialists should provide updated educational materials to inform clinicians about the signs and symptoms of measles and appropriate infection control measures for office and clinic settings. Specialty organizations such as the American Academy of Pediatrics, the American Academy of Family Practitioners, the Infectious Diseases Society of America, and other professional societies must step forward to strongly support vaccination and provide medical guidance. Efforts should also be extended to support our CDC colleagues who have toiled for decades in the interest of public health to ensure their expertise is heard.
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Upcoming Events
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Today. Virtual: Watch April 16 ACIP meeting conclude with votes on chikungunya, MenABCWY, and RSV recommendations.
CDC concludes its first 2025 ACIP ([link removed]) meeting on April 16. On Wednesday, the ACIP will vote on recommendations regarding vaccines targeting chikungunya, meningococcal disease, and RSV.
No registration is required to watch webcasts of live ACIP meetings or listen via telephone.
View the agenda ([link removed]) and anticipated vote language ([link removed]).
Related Links
* CDC: ACIP main page ([link removed]) for access to webcast, agendas
* CDC: ACIP: Meeting Information ([link removed]) for presentation slides, content from previous meetings, and information about future meetings
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Virtual: North Dakota State University hosts webinar titled “Pediatric Vaccine Conversations: Addressing Common Concerns” on April 23 at 1:00 p.m. (ET); CME credit available
North Dakota State University's Center for Immunization Research and Education (CIRE) will host a webinar titled Pediatric Vaccine Conversations: Addressing Common Concerns ([link removed]), 1:00–2:00 p.m. (ET) on April 23. During this webinar, Rebecca Bakke, MD, FAAP, will review questions about childhood vaccinations, discuss research-backed communication strategies, and describe how to engage in empathetic conversations that build trust.
Register for the webinar ([link removed]).
CIRE offers free access to recordings of its monthly webinars on its website. Participants who watch the full recording and complete the pre- and post-training quizzes may earn free CME and maintenance of certification for each webinar. Learn more about CE opportunities ([link removed]).
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Virtual: Register for Immunize.org Website Office Hours. Ask your questions and learn about our affiliated websites on May 7 at 4:00 p.m. ET or May 8 at 12:00 p.m. ET. Previously recorded sessions available online.
To learn simple tips and tricks for using our website efficiently, please register for our next set of Website Office Hours on Wednesday, May 7 at 4:00 p.m. (ET) ([link removed]) or Thursday, May 8 at 12:00 p.m. (ET) ([link removed]). The same content will be covered in both sessions.
We will open each 45-minute session with a short, live demonstration on navigating our affiliated websites, including our educational website for the general public, VaccineInformation.org. You can submit questions when you register or live on Zoom during the session.
Register today for Immunize.org Website Office Hours (content is the same for both):
* Wednesday, May 7 at 4:00 p.m. (ET) ([link removed])
* Thursday, May 8 at 12:00 p.m. (ET) ([link removed])
The archive of previous Website Office Hours content is posted at Immunize.org’s Webinars & Videos ([link removed]) page. These archived webinars include Ask the Experts; Clinical Resources; Vaccine Information Statements (VISs); Images, Webinars, Videos, & Social Media; Official Guidance; Travel Vaccines, Vaccine Confidence & Addressing Concerns; Vaccines A–Z; and Publication Archives, Vaccine Timeline, & About Us.
Mark your calendar ([link removed]) for future Immunize.org Website Office Hours.
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For more upcoming events, visit our Calendar of Events ([link removed]).
Editorial Information
Editor-in-Chief
Kelly L. Moore, MD, MPH
Managing Editor
John D. Grabenstein, RPh, PhD
Associate Editor
Sharon G. Humiston, MD, MPH
Writer/Publication Coordinator
Taryn Chapman, MS
Courtnay Londo, MA
Style and Copy Editor
Marian Deegan, JD
Web Edition Managers
Arkady Shakhnovich
Jermaine Royes
Contributing Writer
Laurel H. Wood, MPA
Technical Reviewer
Kayla Ohlde
About IZ Express
Immunize.org welcomes redistribution of this issue of IZ Express or selected articles.
When you do so, please add a note that Immunize.org is the source of the material and provide a link to this issue ([link removed]).
IZ Express is supported in part by Grant No. NH23IP922654 from the National Center for Immunization and Respiratory Diseases, CDC. Its contents are solely the responsibility of Immunize.org and do not necessarily represent the official views of CDC.
IZ Express Disclaimer (http:// [link removed])
ISSN: 2771-8085
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