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** Epilepsy Research
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** News
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March 2025
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This month, we share the following articles and abstracts which are furthering the study of epilepsy and bringing the world closer to a cure.
* UCLA Team Identifies Brain Rhythms Linked to Seizures in Alzheimer's ([link removed])
* Researchers Identify Genetic Cause of Lennox-Gastaut Syndrome ([link removed])
* Epilepsy AI Tool Detects Brain Lesions Doctors Miss ([link removed])
** UCLA Team Identifies Brain Rhythms Linked to Seizures in Alzheimer's
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A UCLA Health research team has identified changes in brain rhythms that indicate seizure activity in Alzheimer’s patients. Senior author Dr. Keith Vossel’s previous studies showed that silent (non-convulsive) seizures, detected through overnight electroencephalography (EEG) and one-hour magnetoencephalography (MEG), occur in more than 40% of Alzheimer’s disease patients, significantly more than the 20% who experience overt seizures. That research also demonstrated that both silent and overt seizures accelerate cognitive decline. In their latest study, the team analyzed MEG and EEG recordings for high-frequency oscillations (HFOs) which are fast bursts of rhythmic activity indicative of epilepsy.
Learn More ([link removed])
** Researchers Identify Genetic Cause of Lennox-Gastaut Syndrome
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In a recent study, researchers at Baylor College of Medicine and collaborating institutions provided a rare genetic diagnosis in a child with Lennox-Gastaut syndrome, a type of developmental epileptic encephalopathy (DEE) associated with a severe, complex form of epilepsy and developmental delay.
In the study, the team reported the case of a young child with DEE whose previous genomic studies did not provide a genetic diagnosis. Researchers found that a highly complex rearrangement of fragments from certain chromosomes altered the typical organization of genes, leading to a rare condition known as 5q14.3 microdeletion syndrome.
“The child and the family came to Texas Children’s for answers and our team took a closer look at their genome,” said co-author Dr. Hsiao-Tuan Chao. “We reevaluated the child’s genomic condition and found a highly complex reshuffling of chromosomes 3 and 5 resulting in 5q14.3 microdeletion syndrome.”
Learn More ([link removed])
** Epilepsy AI Tool Detects Brain Lesions Doctors Miss
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Researchers have developed an artificial intelligence (AI) tool that can detect two-thirds of epilepsy brain lesions doctors often miss. Brain abnormalities called focal cortical dysplasias are characterized by abnormal development of the outermost layer of the brain, or cerebral cortex. This type of brain abnormality is a common cause of epilepsy, especially medication-resistant epilepsy. Removing a small part of the brain can be a safe and effective way of stopping seizures but if radiologists cannot see the tiny lesions on brain scans, diagnosis, treatment and surgery can be delayed.
For this study the researchers from King’s College London and University College London, fed their tool, called MELD Graph, magnetic-resonance-imaging (MRI) scans from more than 1,185 adults and children at 23 hospitals around the world, 703 of whom had brain abnormalities. The tool was able to process the images more quickly than a doctor could – and in more detail – which could mean more timely treatment and fewer costly tests and procedures, said lead researcher Dr. Konrad Wagstyl.
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