Email
IZ Express #1,796: 2025 immunization schedules published in MMWR, CDC encourages influenza A subtyping, and more
| From | Immunize.org <[email protected]> |
| Subject | IZ Express #1,796: 2025 immunization schedules published in MMWR, CDC encourages influenza A subtyping, and more |
| Date | January 22, 2025 11:02 AM |
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Issue 1,796: January 22, 2025
Top Stories
* 2025 U.S. recommended immunization schedules published in MMWR with articles describing changes (#IZX1)
* CDC issues Health Alert Network (HAN) Health Advisory: “Accelerated Subtyping of Influenza A in Hospitalized Patients” (#IZX2)
* Immunize.org updates its "Standing Orders for Administering Hepatitis B Vaccine to Children and Teens" template (#IZX3)
* Immunize.org updates its resource "Don't Be Guilty of These Preventable Errors in Vaccine Storage and Handling!" (#IZX4)
* I (#IZX5) mmunize.org updates its "Notification of Immunization Letter Template" (#IZX5)
* Influenza activity remains elevated across the country; it's not too late to vaccinate (#IZX6)
* Immunize.org revises "Supplies You May Need at an Immunization Clinic" (#IZX7)
* “How Is RSV Preventive Antibody Different from an RSV Vaccine?” Watch the 2-minute answer, part of the Ask the Experts Video Series on YouTube. (#IZX8)
* IZ Express keeps 52,000+ readers up to date on what’s new in vaccines each week; invite your colleagues to subscribe! (#IZX9)
* Vaccines in the news (#IZX11)
Immunize.org Website and Clinical Resources
* Spotlight on the website: Official Guidance: WHO and FDA (#IZX12)
Featured Resources
* Now shipping! Order laminated 2025 U.S. immunization schedule booklets from Immunize.org. (#IZX13)
* Visit St. Jude’s HPV Cancer Prevention Program for resources for Cervical Cancer Awareness Month and beyond (#IZX14)
* Immunize Kansas Coalition offers HPV education module to help increase HPV vaccination rates; CE credit available (#IZX15)
* National Foundation for Infectious Diseases shares its “U.S. Vaccine Uptake Dashboard” mapping attitudes, behaviors, and barriers to vaccination against respiratory diseases (#IZX16)
* Voices for Vaccines releases podcast featuring Paul Offit, MD, on the role of school vaccine requirements in protecting children (#IZX17)
* CHOP and Pennsylvania pediatricians offer online modules on vaccine communication; CE credit available (#IZX18)
* Moderna offers "Healthy Discussions" simulation to aid healthcare professionals in discussing COVID-19 vaccines with patients (#IZX19)
Notable Publications
* “Invalid Vaccine Doses Among Children Aged 0 to 35 Months: 2011 to 2020” published in Pediatrics (#IZX20)
Upcoming Events
* Questions about our website? Register for Immunize.org Website Office Hours February 12 at 4:00 p.m. (ET) or February 13 at 12:00 p.m. (ET). Previously recorded sessions available online. (#IZX21)
Editorial Information (#Editorial)
------------------------------------------------------------
Top Stories
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2025 U.S. recommended immunization schedules published in MMWR with articles describing changes
On January 16, CDC published two articles in MMWR highlighting the differences between the 2024 and 2025 recommended immunization schedules:
* Advisory Committee on Immunization Practices Recommended Immunization Schedule for Children and Adolescents Aged 18 Years or Younger—United States, 2025 ([link removed])
* Advisory Committee on Immunization Practices Recommended Immunization Schedule for Adults Aged 19 Years or Older—United States, 2025 ([link removed])
The 2025 schedules were originally posted online and available for free download in November 2024 on the CDC Immunization Schedules for Healthcare Providers ([link removed]) main page. Immunize.org offers laminated booklet versions of the 2025 schedules for sale in its online shop ([link removed]) .
The updated schedules for children and adolescents reflect more than a dozen changes to guidance ([link removed]) made by ACIP during 2024, including:
* Adoption of the new Bexsero
(GSK) dosing regimens, matching Trumenba (Pfizer) for MenB
Supplemental doses of COVID-19 vaccine for people with moderate or severe immunocompromise
Timing for nirsevimab (Beyfortus, Sanofi) or maternal RSV vaccine (Abrysvo, Pfizer)
Access the full-color, 17-page PDF of the child/adolescent schedule ([link removed]) .
[link removed]
The 2025 schedules for adults reflect multiple changes to guidance ([link removed]) , ([link removed]) including:
* Revisions to the pneumococcal row for PCV21 and routine PCV use at age 50
* Addition of a polio vaccine row for adults known or suspected of being unimmunized
* Revisions to the RSV row specifying routine use at age 75 or older and risk-based use age 60 through 74
* Supplemental doses of COVID-19 vaccine for people age 65 or older and those with moderate or severe immunocompromise
Access the full-color, 15-page PDF of the adult schedule ([link removed]) .
[link removed]
Related Links
* CDC: Immunization Schedule-Related Resources for Healthcare Providers ([link removed]) main page
* CDC: Vaccine Schedules for You and Your Family ([link removed]) main page, includes links related to vaccination during childhood/adolescence ([link removed]) , adulthood ([link removed]) , and pregnancy ([link removed])
* CDC: Vaccines & Immunizations: Education and Training ([link removed]) main page
Back to top (#Top)
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CDC issues Health Alert Network (HAN) Health Advisory: “Accelerated Subtyping of Influenza A in Hospitalized Patients”
On January 16, CDC issued a Health Alert Network (HAN) ([link removed]) Health Advisory: Accelerated Subtyping of Influenza A in Hospitalized Patients ([link removed]) . CDC issued this notice due to sporadic human infections with avian influenza A(H5N1) viruses amid high levels of seasonal influenza activity. A portion of the summary of the HAN appears below.
Clinicians and laboratorians are reminded to test for influenza in patients with suspected influenza and, going forward, to now expedite the subtyping of influenza A-positive specimens from hospitalized patients, particularly those in an intensive care unit (ICU). This approach can help prevent delays in identifying human infections with avian influenza A(H5N1) viruses, supporting optimal patient care and timely infection control and case investigation.
[link removed]
CDC recommends a shortened timeline for subtyping all influenza A specimens among hospitalized patients and increasing efforts at clinical laboratories to identify nonseasonal influenza.
Related Links
* CDC: Avian Influenza (Bird Flu) ([link removed]) main page
* Immunize.org: Vaccines A–Z: Influenza ([link removed]) main page
Back to top (#Top)
------------------------------------------------------------
Immunize.org updates its "Standing Orders for Administering Hepatitis B Vaccine to Children and Teens" template
Immunize.org made minor updates to its Standing Orders for Administering Hepatitis B Vaccine to Children and Teens ([link removed]) template. All hyperlinks were reviewed and updated as needed, and a note was added to reinforce that teens age 18 years and older who received 2 doses of Heplisav-B at least 4 weeks apart do not need a third dose.
[link removed]
Related Links
* Immunize.org: Clinical Resources: Standing Orders Templates ([link removed]) main page
* Immunize.org: Clinical Resources: Hepatitis B ([link removed]) main page
* Immunize.org: Clinical Resources A–Z ([link removed]) main page, where you can filter by topic, vaccine, language, or other criteria
Back to top (#Top)
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Immunize.org updates its resource "Don't Be Guilty of These Preventable Errors in Vaccine Storage and Handling!"
Immunize.org edited its Don't Be Guilty of These Preventable Errors in Vaccine Storage and Handling! ([link removed]) resource. Updates now indicate that COVID-19 content is now blended into the CDC's main vaccine storage toolkit. Additionally, two new bullets were created to encourage:
* Checking for NSF/ANSI 456 certification indicating compliance with voluntary standards of quality performance when purchasing new vaccine storage units
* Use of digital data loggers for temperature monitoring, which is required for Vaccines for Children (VFC) vaccines
[link removed]
Related Links
* Immunize.org: Clinical Resources: Storage and Handling ([link removed]) main page
* Immunize.org: Clinical Resources A–Z ([link removed]) main page, where you can filter by topic, vaccine, language, or other criteria
Back to top (#Top)
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Immunize.org updates its "Notification of Immunization Letter Template"
Immunize.org updated its Notification of Immunization Letter Template ([link removed]) , removing PreHevbrio from the list of possible immunizations given. VBI Vaccines withdrew PreHevbrio from the U.S. market in fall 2024 for business reasons.
[link removed]
Related Links
* Immunize.org: Clinical Resources: Documenting Vaccination ([link removed]) main page
* Immunize.org: Clinical Resources A–Z ([link removed]) main page, where you can filter by topic, vaccine, language, or other criteria
Back to top (#Top)
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Influenza activity remains elevated across the country; it's not too late to vaccinate
For week 2, ending January 11, CDC’s Weekly U.S. Influenza Surveillance Report, FluView ([link removed]) , showed influenza-like illness activity at high to very high levels in 35 jurisdictions. This week, 5.4% of outpatient visits were for influenza-like illness, well above the epidemic threshold of 3.0% for the seventh consecutive week. Eleven pediatric deaths associated with seasonal influenza virus infection were reported this week, bringing the 2024–25 season total to 27 pediatric deaths.
[link removed]
RESP-NET
Visit the CDC Respiratory Virus Hospitalization Surveillance Network (RESP-NET) ([link removed]) for weekly reports of hospitalizations due to three vaccine-preventable seasonal respiratory viruses: COVID-19, influenza, and RSV.
Influenza Vaccination Dashboard
CDC's Weekly Flu Vaccination Dashboard ([link removed]) shows that, as of January 4, 36.2% of pregnant patients had received influenza vaccination, the same rate as this time in 2024. Vaccination coverage was highest among non-Hispanic Asian pregnant patients (51.6%) and lowest among non-Hispanic Black pregnant patients (24.5%). Vaccination coverage during pregnancy decreased between 2019–20 and 2023–24 overall and in all race and ethnicity groups. Vaccination during pregnancy helps protect both mother and infant from the consequences of influenza infection.
CDC recommends everyone age 6 months and older get annual influenza vaccination. Influenza and other vaccines (e.g., COVID-19 vaccine, RSV vaccine) may be given at the same visit, if needed. Infants age 6 months and older may receive influenza and COVID-19 vaccines at the same visit when they receive nirsevimab (Beyfortus, Sanofi).
Identify pharmacies in your area that may offer influenza and COVID-19 vaccines by entering a zip code in the VaccineFinder on Vaccines.gov ([link removed]) or Vacunas.gov ([link removed]) .
Related Links
* CDC: Weekly National Flu Vaccination Dashboard ([link removed]) main page
* CDC: FluView ([link removed]) main page
* CDC: RESP-NET ([link removed]) main page
* Immunize.org: free clinical resources and patient handouts related to influenza ([link removed])
* Immunize.org: Vaccines A–Z: Influenza ([link removed]) main page
Back to top (#Top)
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Immunize.org revises "Supplies You May Need at an Immunization Clinic"
Immunize.org updated the URLs in its resource, Supplies You May Need at an Immunization Clinic ([link removed]) .
[link removed]
Related Links
* Immunize.org: Clinical Resources: Administering Vaccines ([link removed]) main page
* Immunize.org: Clinical Resources A–Z ([link removed]) main page, where you can filter by topic, vaccine, language, or other criteria
Back to top (#Top)
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“How Is RSV Preventive Antibody Different from an RSV Vaccine?” Watch the 2-minute answer, part of the Ask the Experts Video Series on YouTube.
This week, our featured episode from the Ask the Experts Video Series is How Is RSV Preventive Antibody Different from an RSV Vaccine? ([link removed] ) The video describes how antigens in vaccines activate the immune system. The resulting immune response induces antibody production. In contrast, monoclonal antibodies give the recipient direct, immediate protection through passive immunization.
The 2-minute video is available on our YouTube channel ([link removed]) , along with our full collection of quick video answers to popular Ask the Experts ([link removed]) questions.
[link removed]
Like, follow, and share Immunize.org’s social media accounts and encourage colleagues and others interested in vaccination to do likewise.
* Facebook at ImmunizeOrg ([link removed])
* Instagram at ImmunizeOrg ([link removed])
* LinkedIn at ImmunizeOrg ([link removed])
* YouTube at ImmunizeOrg ([link removed])
Back to top (#Top)
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IZ Express keeps 52,000+ readers up to date on what’s new in vaccines each week; invite your colleagues to subscribe!
Encourage your coworkers to subscribe to ([link removed]) IZ Express ([link removed]) ([link removed]) so they get all the news that matters to vaccinators in their own inbox each Wednesday. It’s free! IZ Express, the weekly e-newsletter produced by Immunize.org, alerts 52,000+ readers to the week’s important vaccine developments. IZ Express also features:
* Educational materials from Immunize.org, CDC, AAP, and others
* Newly posted VISs and their translations
* Notices about online and in-person educational opportunities, many offering free continuing education credit
[link removed]
We appreciate you as a subscriber! Thank you for helping us get the latest vaccine news to every clinical and public health professional who needs to know.
Back to top (#Top)
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Vaccines in the news
These recent articles convey the potential risks of vaccine-preventable diseases and the importance of vaccination.
* Annals of Internal Medicine: Letter from the American College of Physicians to the U.S. Presidential Transition Team ([link removed]) (1/14/25)
* New York Times: Even Adults May Soon Be Vulnerable to ‘Childhood’ Diseases ([link removed]) (1/13/25)
* Washington Post: My Mother Had Polio. We Thought It Was Gone for Good. ([link removed]) (1/13/25)
* New York Times: Don’t Call Kennedy a Vaccine Skeptic. Call Him What He Is: A Cynic. ([link removed]) (commentary) (1/13/25)
* New York Times: Falling Child Vaccination Rates ([link removed]) (1/13/25)
* New York Times: How Lagging Vaccination Could Lead to a Polio Resurgence ([link removed]) (1/13/25)
Back to top (#Top)
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Immunize.org Website and Clinical Resources
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Spotlight on the website: Official Guidance: WHO and FDA
Today, we turn the spotlight on WHO ([link removed]) and FDA ([link removed]) immunization-related resources, which are located under the Official Guidance menu tab atop each page.
Selecting the WHO option under Official Guidance leads you to the World Health Organization ([link removed]) page, which links to current vaccine-specific and general position papers. Also included are links to the Bulletin of the World Health Organization and Weekly Epidemiological Record.
Find direct links to vaccine package inserts ([link removed]) and related content under Official Guidance. Click FDA, then click FDA Package Inserts & EUAs. Use the Vaccine or Disease Name filter to narrow results.
Package inserts can also be accessed from their respective Vaccines A–Z ([link removed]) page. For example, package inserts for both PCV and PPSV vaccines are included on Pneumococcal Vaccine ([link removed]) . View the right menu on this page and click on FDA Package Inserts & EUAs to jump directly to their location.
Back to top (#Top)
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Featured Resources
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Now shipping! Order laminated 2025 U.S. immunization schedule booklets from Immunize.org.
Laminated booklets of the 2025 U.S. child and adolescent immunization schedule ([link removed]) and the 2025 U.S. adult immunization schedule ([link removed]) are available now in the Immunize.org shop. The laminated booklets are shipping now.
The schedules are available online as PDFs from CDC ([link removed]) at no cost. Immunize.org’s laminated booklets are ideal for use in any busy healthcare setting where vaccines are given. Features include:
* Durability: Their tough coating can be wiped down, and they can stand up to a year's worth of use.
* Format: Each schedule is produced in an 8.5” X 11” booklet format; with color coding for easy reading, our laminated schedules replicate the original CDC formatting, including all tables and notes. The adult schedule is 16 pages and the child and adolescent schedule is 20 pages.
* Easy access to CDC updates: The CDC online schedule includes an addendum page that will display ACIP’s new recommendations as CDC adopts them during 2025. Each Immunize.org laminated schedule addendum page includes QR codes you can scan to view or print the online addendum page as it is revised.
* Bonus content: Both schedules include a bonus page with Immunize.org’s popular 1-page handout summarizing the dose, route, and needle size recommendations for all vaccines and recipients.
[link removed] [link removed]
Pricing:
Child and Adolescent Booklets Adult Booklets ([link removed])
1 copy: $10.50 1 copy: $10.00
2–4 copies: $10.00 each 2–4 copies: $9.50 each
5–19 copies: $9.00 each 5–19 copies: $8.50 each
20–99 copies: $8.00 each 20–99 copies: $7.50 each
100–499 copies: $6.50 each 100–499 copies: $6.00 each
500–999 copies: $5.50 each 500–999 copies: $5.00 each
1,000–1,999 copies: $4.50 each 1,000–1,999 copies: $4.00 each
2,000+ copies: $3.75 each 2,000+ copies: $3.25 each
Visit the Shop Immunize.org: Laminated Schedules ([link removed]) web page to view images and preorder today!
For additional information, call 651-647-9009 or email [email protected] (mailto:[email protected]) .
Related Links
* Immunize.org: Laminated Child and Adolescent Immunization Schedules (0–18 years) ([link removed]) web page
* Immunize.org: Laminated Adult Immunization Schedules (19 and older) ([link removed]) web page
* Immunize.org: Shop Immunize.org ([link removed]) main page
Back to top (#Top)
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Visit St. Jude’s HPV Cancer Prevention Program for resources for Cervical Cancer Awareness Month and beyond
The St. Jude HPV Cancer Prevention Program website ([link removed]) identifies opportunities for increasing HPV vaccination. You will find a wide range of HPV- and HPV-vaccine-related resources.
[link removed]
Visit St. Jude HPV Prevention Program ([link removed]) to view the resources.
Back to top (#Top)
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Immunize Kansas Coalition offers HPV education module to help increase HPV vaccination rates; CE credit available
Immunize Kansas Coalition's ([link removed]) (IKC) updated and accredited its Shutting the Door on HPV Cancers ([link removed]) module, available at no cost. The module’s development team included Immunize.org’s Sharon G. Humiston, MD, MPH. During Cervical Cancer Awareness Month, IKC will focus on increasing HPV vaccination rates, emphasizing the vaccine's proven protection against cervical precancers and cancers.
This is a 0.5-hour continuing education (CE) activity. CE is available at no cost to physicians, pharmacists, physician assistants, nurses, and nurse practitioners.
[link removed]
View the education module ([link removed]) .
See all of IKC's education modules ([link removed]) .
Back to top (#Top)
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National Foundation for Infectious Diseases shares its “U.S. Vaccine Uptake Dashboard” mapping attitudes, behaviors, and barriers to vaccination against respiratory diseases
The National Foundation for Infectious Diseases ([link removed]) (NFID) and partners created the U.S. Vaccine Update Dashboard ([link removed]) . This tool aims to improve adult vaccine uptake by tracking motivation and access barriers to vaccination against COVID-19, influenza, RSV, and pneumococcal disease. Users can view health data at the state, county, and zip code levels and compare geographies based on intent to get vaccinated.
[link removed]
Request access to the dashboard ([link removed]) .
Back to top (#Top)
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Voices for Vaccines releases podcast featuring Paul Offit, MD, on the role of school vaccine requirements in protecting children
Voices for Vaccines ([link removed]) (VFV) posted a new entry in its Vax Talk ([link removed]) podcast series: Vaccines Are Required for School ([link removed] ) featuring Paul Offit, MD. A description from the VFV web page appears below.
The conversation delves into pivotal moments in vaccine policy history, from the early days of state mandates to modern challenges facing public health measures. Dr. Offit recalls his firsthand experience with Philadelphia’s devastating 1991 measles outbreak and discusses how the 2014 Disneyland outbreak led to significant policy changes in California. The discussion tackles complex issues around religious and philosophical exemptions, the impact on vulnerable populations, and growing concerns about vaccine hesitancy in the post-COVID era.
Back to top (#Top)
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CHOP and Pennsylvania pediatricians offer online modules on vaccine communication; CE credit available
Children’s Hospital of Philadelphia (CHOP) Vaccine Education Center (VEC), the Pennsylvania Chapter of the American Academy of Pediatrics, and partners developed four free web-based, interactive learning modules related to vaccines ([link removed]) . Several modules offer CME and CNE credit. The project’s development team included Immunize.org’s Sharon G. Humiston, MD, MPH.
[link removed]
View the modules ([link removed]) .
Back to top (#Top)
------------------------------------------------------------
Moderna offers "Healthy Discussions" simulation to aid healthcare professionals in discussing COVID-19 vaccines with patients
Moderna developed a web-based simulation game called Healthy Discussions ([link removed]) to help healthcare professionals hold stronger COVID-19 vaccination conversations with their patients. The game shows how to incorporate data around personal risk, use presumptive language, and frame dialogue for responding to patient concerns. Each scenario in the game takes no more than 5 minutes.
Other than a disclaimer stating "brought to you by Moderna," there is no mention of specific products or manufacturers.
View Healthy Discussions ([link removed]) .
Back to top (#Top)
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Notable Publications
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“Invalid Vaccine Doses Among Children Aged 0 to 35 Months: 2011 to 2020” published in Pediatrics
In the January 10 issue, Pediatrics published Invalid Vaccine Doses Among Children Aged 0 to 35 Months: 2011 to 2020 ([link removed]) . The Results section appears below.
[Among 161,187 children, 15.4%] had an invalid vaccine dose. Of children with a minimum age or minimum interval invalid dose, 44.9% . . . received extra doses and completed the series. The highest prevalence of invalid doses was for 3-dose rotavirus (n = 5733, 4.4%), with the first dose being administered after the maximum age (n = 3996, 3.1%). Overall, the percentage of children with an invalid dose decreased from 2011 (16.9%) to 2020 (12.5%). Children who moved across state lines vs not . . . had higher odds of an invalid vaccine dose.
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Upcoming Events
------------------------------------------------------------
Questions about our website? Register for Immunize.org Website Office Hours February 12 at 4:00 p.m. (ET) or February 13 at 12:00 p.m. (ET). Previously recorded sessions available online.
To learn simple tips and tricks for using our website efficiently, please register for our next set of Website Office Hours on Wednesday, February 12 at 4:00 p.m. (ET) ([link removed]) or Thursday, February 13 at 12:00 p.m. (ET) ([link removed]) . The same content will be covered in both sessions.
We will open each 45-minute session with a short, live demonstration on navigating the Official Guidance ([link removed]) (part 2: state resources) website section and address questions submitted in advance. This section is extremely useful for those who want to know about state immunization requirements for school and childcare. You can submit questions when you register or live on Zoom during the session.
Register today for Immunize.org Website Office Hours (content is the same for both):
* Wednesday, February 12 at 4:00 p.m. (ET) ([link removed])
* Thursday, February 13 at 12:00 p.m. (ET) ([link removed])
The archive of previous Website Office Hours content is posted at Immunize.org’s Webinars & Videos ([link removed]) page.
Mark your calendar ([link removed]) for future Immunize.org Website Office Hours.
Back to top (#Top)
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For more upcoming events, visit our Calendar of Events ([link removed]) .
Editorial Information
Editor-in-Chief
Kelly L. Moore, MD, MPH
Managing Editor
John D. Grabenstein, RPh, PhD
Associate Editor
Sharon G. Humiston, MD, MPH
Writer/Publication Coordinator
Taryn Chapman, MS
Courtnay Londo, MA
Style and Copy Editor
Marian Deegan, JD
Web Edition Managers
Arkady Shakhnovich
Jermaine Royes
Contributing Writer
Laurel H. Wood, MPA
Technical Reviewer
Kayla Ohlde
About IZ Express
Immunize.org welcomes redistribution of this issue of IZ Express or selected articles.
When you do so, please add a note that Immunize.org is the source of the material and provide a link to this issue ([link removed]) .
IZ Express is supported in part by Grant No. NH23IP922654 from the National Center for Immunization and Respiratory Diseases, CDC. Its contents are solely the responsibility of Immunize.org and do not necessarily represent the official views of CDC.
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Issue 1,796: January 22, 2025
Top Stories
* 2025 U.S. recommended immunization schedules published in MMWR with articles describing changes (#IZX1)
* CDC issues Health Alert Network (HAN) Health Advisory: “Accelerated Subtyping of Influenza A in Hospitalized Patients” (#IZX2)
* Immunize.org updates its "Standing Orders for Administering Hepatitis B Vaccine to Children and Teens" template (#IZX3)
* Immunize.org updates its resource "Don't Be Guilty of These Preventable Errors in Vaccine Storage and Handling!" (#IZX4)
* I (#IZX5) mmunize.org updates its "Notification of Immunization Letter Template" (#IZX5)
* Influenza activity remains elevated across the country; it's not too late to vaccinate (#IZX6)
* Immunize.org revises "Supplies You May Need at an Immunization Clinic" (#IZX7)
* “How Is RSV Preventive Antibody Different from an RSV Vaccine?” Watch the 2-minute answer, part of the Ask the Experts Video Series on YouTube. (#IZX8)
* IZ Express keeps 52,000+ readers up to date on what’s new in vaccines each week; invite your colleagues to subscribe! (#IZX9)
* Vaccines in the news (#IZX11)
Immunize.org Website and Clinical Resources
* Spotlight on the website: Official Guidance: WHO and FDA (#IZX12)
Featured Resources
* Now shipping! Order laminated 2025 U.S. immunization schedule booklets from Immunize.org. (#IZX13)
* Visit St. Jude’s HPV Cancer Prevention Program for resources for Cervical Cancer Awareness Month and beyond (#IZX14)
* Immunize Kansas Coalition offers HPV education module to help increase HPV vaccination rates; CE credit available (#IZX15)
* National Foundation for Infectious Diseases shares its “U.S. Vaccine Uptake Dashboard” mapping attitudes, behaviors, and barriers to vaccination against respiratory diseases (#IZX16)
* Voices for Vaccines releases podcast featuring Paul Offit, MD, on the role of school vaccine requirements in protecting children (#IZX17)
* CHOP and Pennsylvania pediatricians offer online modules on vaccine communication; CE credit available (#IZX18)
* Moderna offers "Healthy Discussions" simulation to aid healthcare professionals in discussing COVID-19 vaccines with patients (#IZX19)
Notable Publications
* “Invalid Vaccine Doses Among Children Aged 0 to 35 Months: 2011 to 2020” published in Pediatrics (#IZX20)
Upcoming Events
* Questions about our website? Register for Immunize.org Website Office Hours February 12 at 4:00 p.m. (ET) or February 13 at 12:00 p.m. (ET). Previously recorded sessions available online. (#IZX21)
Editorial Information (#Editorial)
------------------------------------------------------------
Top Stories
------------------------------------------------------------
2025 U.S. recommended immunization schedules published in MMWR with articles describing changes
On January 16, CDC published two articles in MMWR highlighting the differences between the 2024 and 2025 recommended immunization schedules:
* Advisory Committee on Immunization Practices Recommended Immunization Schedule for Children and Adolescents Aged 18 Years or Younger—United States, 2025 ([link removed])
* Advisory Committee on Immunization Practices Recommended Immunization Schedule for Adults Aged 19 Years or Older—United States, 2025 ([link removed])
The 2025 schedules were originally posted online and available for free download in November 2024 on the CDC Immunization Schedules for Healthcare Providers ([link removed]) main page. Immunize.org offers laminated booklet versions of the 2025 schedules for sale in its online shop ([link removed]) .
The updated schedules for children and adolescents reflect more than a dozen changes to guidance ([link removed]) made by ACIP during 2024, including:
* Adoption of the new Bexsero
(GSK) dosing regimens, matching Trumenba (Pfizer) for MenB
Supplemental doses of COVID-19 vaccine for people with moderate or severe immunocompromise
Timing for nirsevimab (Beyfortus, Sanofi) or maternal RSV vaccine (Abrysvo, Pfizer)
Access the full-color, 17-page PDF of the child/adolescent schedule ([link removed]) .
[link removed]
The 2025 schedules for adults reflect multiple changes to guidance ([link removed]) , ([link removed]) including:
* Revisions to the pneumococcal row for PCV21 and routine PCV use at age 50
* Addition of a polio vaccine row for adults known or suspected of being unimmunized
* Revisions to the RSV row specifying routine use at age 75 or older and risk-based use age 60 through 74
* Supplemental doses of COVID-19 vaccine for people age 65 or older and those with moderate or severe immunocompromise
Access the full-color, 15-page PDF of the adult schedule ([link removed]) .
[link removed]
Related Links
* CDC: Immunization Schedule-Related Resources for Healthcare Providers ([link removed]) main page
* CDC: Vaccine Schedules for You and Your Family ([link removed]) main page, includes links related to vaccination during childhood/adolescence ([link removed]) , adulthood ([link removed]) , and pregnancy ([link removed])
* CDC: Vaccines & Immunizations: Education and Training ([link removed]) main page
Back to top (#Top)
------------------------------------------------------------
CDC issues Health Alert Network (HAN) Health Advisory: “Accelerated Subtyping of Influenza A in Hospitalized Patients”
On January 16, CDC issued a Health Alert Network (HAN) ([link removed]) Health Advisory: Accelerated Subtyping of Influenza A in Hospitalized Patients ([link removed]) . CDC issued this notice due to sporadic human infections with avian influenza A(H5N1) viruses amid high levels of seasonal influenza activity. A portion of the summary of the HAN appears below.
Clinicians and laboratorians are reminded to test for influenza in patients with suspected influenza and, going forward, to now expedite the subtyping of influenza A-positive specimens from hospitalized patients, particularly those in an intensive care unit (ICU). This approach can help prevent delays in identifying human infections with avian influenza A(H5N1) viruses, supporting optimal patient care and timely infection control and case investigation.
[link removed]
CDC recommends a shortened timeline for subtyping all influenza A specimens among hospitalized patients and increasing efforts at clinical laboratories to identify nonseasonal influenza.
Related Links
* CDC: Avian Influenza (Bird Flu) ([link removed]) main page
* Immunize.org: Vaccines A–Z: Influenza ([link removed]) main page
Back to top (#Top)
------------------------------------------------------------
Immunize.org updates its "Standing Orders for Administering Hepatitis B Vaccine to Children and Teens" template
Immunize.org made minor updates to its Standing Orders for Administering Hepatitis B Vaccine to Children and Teens ([link removed]) template. All hyperlinks were reviewed and updated as needed, and a note was added to reinforce that teens age 18 years and older who received 2 doses of Heplisav-B at least 4 weeks apart do not need a third dose.
[link removed]
Related Links
* Immunize.org: Clinical Resources: Standing Orders Templates ([link removed]) main page
* Immunize.org: Clinical Resources: Hepatitis B ([link removed]) main page
* Immunize.org: Clinical Resources A–Z ([link removed]) main page, where you can filter by topic, vaccine, language, or other criteria
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Immunize.org updates its resource "Don't Be Guilty of These Preventable Errors in Vaccine Storage and Handling!"
Immunize.org edited its Don't Be Guilty of These Preventable Errors in Vaccine Storage and Handling! ([link removed]) resource. Updates now indicate that COVID-19 content is now blended into the CDC's main vaccine storage toolkit. Additionally, two new bullets were created to encourage:
* Checking for NSF/ANSI 456 certification indicating compliance with voluntary standards of quality performance when purchasing new vaccine storage units
* Use of digital data loggers for temperature monitoring, which is required for Vaccines for Children (VFC) vaccines
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Related Links
* Immunize.org: Clinical Resources: Storage and Handling ([link removed]) main page
* Immunize.org: Clinical Resources A–Z ([link removed]) main page, where you can filter by topic, vaccine, language, or other criteria
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Immunize.org updates its "Notification of Immunization Letter Template"
Immunize.org updated its Notification of Immunization Letter Template ([link removed]) , removing PreHevbrio from the list of possible immunizations given. VBI Vaccines withdrew PreHevbrio from the U.S. market in fall 2024 for business reasons.
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Related Links
* Immunize.org: Clinical Resources: Documenting Vaccination ([link removed]) main page
* Immunize.org: Clinical Resources A–Z ([link removed]) main page, where you can filter by topic, vaccine, language, or other criteria
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Influenza activity remains elevated across the country; it's not too late to vaccinate
For week 2, ending January 11, CDC’s Weekly U.S. Influenza Surveillance Report, FluView ([link removed]) , showed influenza-like illness activity at high to very high levels in 35 jurisdictions. This week, 5.4% of outpatient visits were for influenza-like illness, well above the epidemic threshold of 3.0% for the seventh consecutive week. Eleven pediatric deaths associated with seasonal influenza virus infection were reported this week, bringing the 2024–25 season total to 27 pediatric deaths.
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RESP-NET
Visit the CDC Respiratory Virus Hospitalization Surveillance Network (RESP-NET) ([link removed]) for weekly reports of hospitalizations due to three vaccine-preventable seasonal respiratory viruses: COVID-19, influenza, and RSV.
Influenza Vaccination Dashboard
CDC's Weekly Flu Vaccination Dashboard ([link removed]) shows that, as of January 4, 36.2% of pregnant patients had received influenza vaccination, the same rate as this time in 2024. Vaccination coverage was highest among non-Hispanic Asian pregnant patients (51.6%) and lowest among non-Hispanic Black pregnant patients (24.5%). Vaccination coverage during pregnancy decreased between 2019–20 and 2023–24 overall and in all race and ethnicity groups. Vaccination during pregnancy helps protect both mother and infant from the consequences of influenza infection.
CDC recommends everyone age 6 months and older get annual influenza vaccination. Influenza and other vaccines (e.g., COVID-19 vaccine, RSV vaccine) may be given at the same visit, if needed. Infants age 6 months and older may receive influenza and COVID-19 vaccines at the same visit when they receive nirsevimab (Beyfortus, Sanofi).
Identify pharmacies in your area that may offer influenza and COVID-19 vaccines by entering a zip code in the VaccineFinder on Vaccines.gov ([link removed]) or Vacunas.gov ([link removed]) .
Related Links
* CDC: Weekly National Flu Vaccination Dashboard ([link removed]) main page
* CDC: FluView ([link removed]) main page
* CDC: RESP-NET ([link removed]) main page
* Immunize.org: free clinical resources and patient handouts related to influenza ([link removed])
* Immunize.org: Vaccines A–Z: Influenza ([link removed]) main page
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Immunize.org revises "Supplies You May Need at an Immunization Clinic"
Immunize.org updated the URLs in its resource, Supplies You May Need at an Immunization Clinic ([link removed]) .
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Related Links
* Immunize.org: Clinical Resources: Administering Vaccines ([link removed]) main page
* Immunize.org: Clinical Resources A–Z ([link removed]) main page, where you can filter by topic, vaccine, language, or other criteria
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“How Is RSV Preventive Antibody Different from an RSV Vaccine?” Watch the 2-minute answer, part of the Ask the Experts Video Series on YouTube.
This week, our featured episode from the Ask the Experts Video Series is How Is RSV Preventive Antibody Different from an RSV Vaccine? ([link removed] ) The video describes how antigens in vaccines activate the immune system. The resulting immune response induces antibody production. In contrast, monoclonal antibodies give the recipient direct, immediate protection through passive immunization.
The 2-minute video is available on our YouTube channel ([link removed]) , along with our full collection of quick video answers to popular Ask the Experts ([link removed]) questions.
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Like, follow, and share Immunize.org’s social media accounts and encourage colleagues and others interested in vaccination to do likewise.
* Facebook at ImmunizeOrg ([link removed])
* Instagram at ImmunizeOrg ([link removed])
* LinkedIn at ImmunizeOrg ([link removed])
* YouTube at ImmunizeOrg ([link removed])
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IZ Express keeps 52,000+ readers up to date on what’s new in vaccines each week; invite your colleagues to subscribe!
Encourage your coworkers to subscribe to ([link removed]) IZ Express ([link removed]) ([link removed]) so they get all the news that matters to vaccinators in their own inbox each Wednesday. It’s free! IZ Express, the weekly e-newsletter produced by Immunize.org, alerts 52,000+ readers to the week’s important vaccine developments. IZ Express also features:
* Educational materials from Immunize.org, CDC, AAP, and others
* Newly posted VISs and their translations
* Notices about online and in-person educational opportunities, many offering free continuing education credit
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We appreciate you as a subscriber! Thank you for helping us get the latest vaccine news to every clinical and public health professional who needs to know.
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Vaccines in the news
These recent articles convey the potential risks of vaccine-preventable diseases and the importance of vaccination.
* Annals of Internal Medicine: Letter from the American College of Physicians to the U.S. Presidential Transition Team ([link removed]) (1/14/25)
* New York Times: Even Adults May Soon Be Vulnerable to ‘Childhood’ Diseases ([link removed]) (1/13/25)
* Washington Post: My Mother Had Polio. We Thought It Was Gone for Good. ([link removed]) (1/13/25)
* New York Times: Don’t Call Kennedy a Vaccine Skeptic. Call Him What He Is: A Cynic. ([link removed]) (commentary) (1/13/25)
* New York Times: Falling Child Vaccination Rates ([link removed]) (1/13/25)
* New York Times: How Lagging Vaccination Could Lead to a Polio Resurgence ([link removed]) (1/13/25)
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Immunize.org Website and Clinical Resources
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Spotlight on the website: Official Guidance: WHO and FDA
Today, we turn the spotlight on WHO ([link removed]) and FDA ([link removed]) immunization-related resources, which are located under the Official Guidance menu tab atop each page.
Selecting the WHO option under Official Guidance leads you to the World Health Organization ([link removed]) page, which links to current vaccine-specific and general position papers. Also included are links to the Bulletin of the World Health Organization and Weekly Epidemiological Record.
Find direct links to vaccine package inserts ([link removed]) and related content under Official Guidance. Click FDA, then click FDA Package Inserts & EUAs. Use the Vaccine or Disease Name filter to narrow results.
Package inserts can also be accessed from their respective Vaccines A–Z ([link removed]) page. For example, package inserts for both PCV and PPSV vaccines are included on Pneumococcal Vaccine ([link removed]) . View the right menu on this page and click on FDA Package Inserts & EUAs to jump directly to their location.
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Featured Resources
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Now shipping! Order laminated 2025 U.S. immunization schedule booklets from Immunize.org.
Laminated booklets of the 2025 U.S. child and adolescent immunization schedule ([link removed]) and the 2025 U.S. adult immunization schedule ([link removed]) are available now in the Immunize.org shop. The laminated booklets are shipping now.
The schedules are available online as PDFs from CDC ([link removed]) at no cost. Immunize.org’s laminated booklets are ideal for use in any busy healthcare setting where vaccines are given. Features include:
* Durability: Their tough coating can be wiped down, and they can stand up to a year's worth of use.
* Format: Each schedule is produced in an 8.5” X 11” booklet format; with color coding for easy reading, our laminated schedules replicate the original CDC formatting, including all tables and notes. The adult schedule is 16 pages and the child and adolescent schedule is 20 pages.
* Easy access to CDC updates: The CDC online schedule includes an addendum page that will display ACIP’s new recommendations as CDC adopts them during 2025. Each Immunize.org laminated schedule addendum page includes QR codes you can scan to view or print the online addendum page as it is revised.
* Bonus content: Both schedules include a bonus page with Immunize.org’s popular 1-page handout summarizing the dose, route, and needle size recommendations for all vaccines and recipients.
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Pricing:
Child and Adolescent Booklets Adult Booklets ([link removed])
1 copy: $10.50 1 copy: $10.00
2–4 copies: $10.00 each 2–4 copies: $9.50 each
5–19 copies: $9.00 each 5–19 copies: $8.50 each
20–99 copies: $8.00 each 20–99 copies: $7.50 each
100–499 copies: $6.50 each 100–499 copies: $6.00 each
500–999 copies: $5.50 each 500–999 copies: $5.00 each
1,000–1,999 copies: $4.50 each 1,000–1,999 copies: $4.00 each
2,000+ copies: $3.75 each 2,000+ copies: $3.25 each
Visit the Shop Immunize.org: Laminated Schedules ([link removed]) web page to view images and preorder today!
For additional information, call 651-647-9009 or email [email protected] (mailto:[email protected]) .
Related Links
* Immunize.org: Laminated Child and Adolescent Immunization Schedules (0–18 years) ([link removed]) web page
* Immunize.org: Laminated Adult Immunization Schedules (19 and older) ([link removed]) web page
* Immunize.org: Shop Immunize.org ([link removed]) main page
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Visit St. Jude’s HPV Cancer Prevention Program for resources for Cervical Cancer Awareness Month and beyond
The St. Jude HPV Cancer Prevention Program website ([link removed]) identifies opportunities for increasing HPV vaccination. You will find a wide range of HPV- and HPV-vaccine-related resources.
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Visit St. Jude HPV Prevention Program ([link removed]) to view the resources.
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Immunize Kansas Coalition offers HPV education module to help increase HPV vaccination rates; CE credit available
Immunize Kansas Coalition's ([link removed]) (IKC) updated and accredited its Shutting the Door on HPV Cancers ([link removed]) module, available at no cost. The module’s development team included Immunize.org’s Sharon G. Humiston, MD, MPH. During Cervical Cancer Awareness Month, IKC will focus on increasing HPV vaccination rates, emphasizing the vaccine's proven protection against cervical precancers and cancers.
This is a 0.5-hour continuing education (CE) activity. CE is available at no cost to physicians, pharmacists, physician assistants, nurses, and nurse practitioners.
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View the education module ([link removed]) .
See all of IKC's education modules ([link removed]) .
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National Foundation for Infectious Diseases shares its “U.S. Vaccine Uptake Dashboard” mapping attitudes, behaviors, and barriers to vaccination against respiratory diseases
The National Foundation for Infectious Diseases ([link removed]) (NFID) and partners created the U.S. Vaccine Update Dashboard ([link removed]) . This tool aims to improve adult vaccine uptake by tracking motivation and access barriers to vaccination against COVID-19, influenza, RSV, and pneumococcal disease. Users can view health data at the state, county, and zip code levels and compare geographies based on intent to get vaccinated.
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Request access to the dashboard ([link removed]) .
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Voices for Vaccines releases podcast featuring Paul Offit, MD, on the role of school vaccine requirements in protecting children
Voices for Vaccines ([link removed]) (VFV) posted a new entry in its Vax Talk ([link removed]) podcast series: Vaccines Are Required for School ([link removed] ) featuring Paul Offit, MD. A description from the VFV web page appears below.
The conversation delves into pivotal moments in vaccine policy history, from the early days of state mandates to modern challenges facing public health measures. Dr. Offit recalls his firsthand experience with Philadelphia’s devastating 1991 measles outbreak and discusses how the 2014 Disneyland outbreak led to significant policy changes in California. The discussion tackles complex issues around religious and philosophical exemptions, the impact on vulnerable populations, and growing concerns about vaccine hesitancy in the post-COVID era.
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CHOP and Pennsylvania pediatricians offer online modules on vaccine communication; CE credit available
Children’s Hospital of Philadelphia (CHOP) Vaccine Education Center (VEC), the Pennsylvania Chapter of the American Academy of Pediatrics, and partners developed four free web-based, interactive learning modules related to vaccines ([link removed]) . Several modules offer CME and CNE credit. The project’s development team included Immunize.org’s Sharon G. Humiston, MD, MPH.
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View the modules ([link removed]) .
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Moderna offers "Healthy Discussions" simulation to aid healthcare professionals in discussing COVID-19 vaccines with patients
Moderna developed a web-based simulation game called Healthy Discussions ([link removed]) to help healthcare professionals hold stronger COVID-19 vaccination conversations with their patients. The game shows how to incorporate data around personal risk, use presumptive language, and frame dialogue for responding to patient concerns. Each scenario in the game takes no more than 5 minutes.
Other than a disclaimer stating "brought to you by Moderna," there is no mention of specific products or manufacturers.
View Healthy Discussions ([link removed]) .
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Notable Publications
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“Invalid Vaccine Doses Among Children Aged 0 to 35 Months: 2011 to 2020” published in Pediatrics
In the January 10 issue, Pediatrics published Invalid Vaccine Doses Among Children Aged 0 to 35 Months: 2011 to 2020 ([link removed]) . The Results section appears below.
[Among 161,187 children, 15.4%] had an invalid vaccine dose. Of children with a minimum age or minimum interval invalid dose, 44.9% . . . received extra doses and completed the series. The highest prevalence of invalid doses was for 3-dose rotavirus (n = 5733, 4.4%), with the first dose being administered after the maximum age (n = 3996, 3.1%). Overall, the percentage of children with an invalid dose decreased from 2011 (16.9%) to 2020 (12.5%). Children who moved across state lines vs not . . . had higher odds of an invalid vaccine dose.
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Upcoming Events
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Questions about our website? Register for Immunize.org Website Office Hours February 12 at 4:00 p.m. (ET) or February 13 at 12:00 p.m. (ET). Previously recorded sessions available online.
To learn simple tips and tricks for using our website efficiently, please register for our next set of Website Office Hours on Wednesday, February 12 at 4:00 p.m. (ET) ([link removed]) or Thursday, February 13 at 12:00 p.m. (ET) ([link removed]) . The same content will be covered in both sessions.
We will open each 45-minute session with a short, live demonstration on navigating the Official Guidance ([link removed]) (part 2: state resources) website section and address questions submitted in advance. This section is extremely useful for those who want to know about state immunization requirements for school and childcare. You can submit questions when you register or live on Zoom during the session.
Register today for Immunize.org Website Office Hours (content is the same for both):
* Wednesday, February 12 at 4:00 p.m. (ET) ([link removed])
* Thursday, February 13 at 12:00 p.m. (ET) ([link removed])
The archive of previous Website Office Hours content is posted at Immunize.org’s Webinars & Videos ([link removed]) page.
Mark your calendar ([link removed]) for future Immunize.org Website Office Hours.
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For more upcoming events, visit our Calendar of Events ([link removed]) .
Editorial Information
Editor-in-Chief
Kelly L. Moore, MD, MPH
Managing Editor
John D. Grabenstein, RPh, PhD
Associate Editor
Sharon G. Humiston, MD, MPH
Writer/Publication Coordinator
Taryn Chapman, MS
Courtnay Londo, MA
Style and Copy Editor
Marian Deegan, JD
Web Edition Managers
Arkady Shakhnovich
Jermaine Royes
Contributing Writer
Laurel H. Wood, MPA
Technical Reviewer
Kayla Ohlde
About IZ Express
Immunize.org welcomes redistribution of this issue of IZ Express or selected articles.
When you do so, please add a note that Immunize.org is the source of the material and provide a link to this issue ([link removed]) .
IZ Express is supported in part by Grant No. NH23IP922654 from the National Center for Immunization and Respiratory Diseases, CDC. Its contents are solely the responsibility of Immunize.org and do not necessarily represent the official views of CDC.
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