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- The top 25 stories curated by editors and fellow readers!

Editor's Pick

How Scientific Incentives Stalled the Fight Against Antibiotic Resistance, and How We Can Fix It
Sree VijaykumarFor all of human history until the past 100 years, infectious diseases have been our deadliest foe. Even during the roaring 1920s, nearly one in a hundred Americans would die of an infectious disease every year. To put that into context, the US infectious disease death rate was 10x lower during the height of the COVID-19 pandemic in 2021. The glorious relief we enjoy from the ancient specter of deadly disease is due in large part to development of antibiotic treatments like penicillin.

But this relief may soon be coming to an end. If nothing is done, antibiotic resistance promises a return to the historical norm of frequent death from infectious disease. As humans use more antibiotics, we are inadvertently running the world's largest selective breeding program for bacteria which can survive our onslaught of drugs. Already by the late 1960s, 80% of cases of Staphylococcus aureus, a common and notorious bacterial infection agent, were resistant to penicillin. Since then, we have discovered many more powerful antibiotic drugs, but our use of the drugs is growing rapidly, while our discovery rate is stagnating at best.

Continued here


Editor's Note: The most promising solution to antibiotic resistance comes from dragon blood. Komodo dragons, native to a few small islands in Indonesia, are the world's largest lizards. They eat carrion and live in swamps, and their saliva hosts many of the world's most stubborn and infectious bacteria. But Komodos almost never get infected. Even when they have open wounds, Komodo dragons can trudge happily along through rotting corpses and mud without a worry.



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Startup founders flooded inauguration parties hopeful for dealmaking | TechCrunch
Startup founders flooded inauguration parties hopeful for dealmaking | TechCrunch
If this weekend shows anything, it’s that the hardest challenge founders will face, between balls and Mar-a-Lago trips, might just be staying focused on their day job. “There’s people who are trying to be in the right room,” Taylor said. “And there are people trying to get the work done.” 


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Why Gen Z Is Drinking Less
Why Gen Z Is Drinking Less
Gen Z is drinking less alcohol than previous generations. There isn't one clear reason for the, but experts point to a variety of factors.






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Why have you read 'The Great Gatsby' but not Ursula Parrott's 'Ex-Wife'?
Why have you read 'The Great Gatsby' but not Ursula Parrott's 'Ex-Wife'?
In 1925, F. Scott Fitzgerald published "The Great Gatsby." Four years later, Ursula Parrott published her first novel, "Ex-Wife." I probably read "The Great Gatsby" a dozen times between junior high school and my late 20s.


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The Gilded Age novel that helps explain our fascination with Luigi Mangione
The Gilded Age novel that helps explain our fascination with Luigi Mangione
A good-looking young man with a mysterious past carries a loaded gun, ready to kill, on the streets of the world's financial capital.




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The Unexpected Power Of Outsiders In Building Innovative Teams
No one keeps a job for life anymore. Looking for brilliance outside a specific niche opens your business up to the best people out there. At Atom.com, we've recently expanded our team. We were specific about what we wanted, and we now have a team that works extremely well together.


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Dutch pension funds divest from Tesla
Dutch pension funds divest from Tesla
ABP and Bpf Bouw, two of the largest four pension funds in the Netherlands with over EUR600bn in assets between them, have sold their shares in Tesla over ESG concerns




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What comes after Design thinking
What comes after Design thinking
The popular methodology isn't equipped to solve the complexities of the current world. If you've been in business or innovation circles in the past ten years, chances are you have experimented with design thinking.


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David Lynch's Enchanting Sound Worlds
David Lynch's Enchanting Sound Worlds
David Lynch, the filmmaker whose death at 78 was announced Thursday, was known for his surreal visions that mix the macabre with the everyday.




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Man Diagnosed With Rare Kidney Disease Thanks ChatGPT For 'Saving His Life'
Man Diagnosed With Rare Kidney Disease Thanks ChatGPT For 'Saving His Life'
The AI chatbot evaluated that the symptoms were associated with "moderate to severe Rhabdomyolysis" and its prediction turned out to be accurate. The man had developed severe Rhabdomyolysis due to intense workout.


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I clock up to 20,000 steps a night: my life with restless legs syndrome
I clock up to 20,000 steps a night: my life with restless legs syndrome
I'd always known something was wrong with my legs. When I was a teenager, my best friend and I shared her full-sized bed - she would wake me up, giggling: "Lying next to you is like trying to sleep through an earthquake!" Now I'm 45, and my boyfriend says the same thing.




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Tanzania confirms Marburg virus outbreak after initial denial
Tanzania confirms Marburg virus outbreak after initial denial
Tanzania's president has announced an outbreak of Marburg virus, an Ebola-like virus, just a week after her health minister denied that there were any cases in the country.


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Game Developers Are Getting Fed Up With Their Bosses' AI Initiatives
Game Developers Are Getting Fed Up With Their Bosses' AI Initiatives
The video game industry has been in a troubled place for the past year, with studio closures and job security at the forefront of developer concerns. Increasing layoffs with seemingly no end paint a bleak picture for devs, while companies are busy pumping money into AI initiatives.




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Calm Tech Certification "Rewards" Less Distracting Tech
Calm Tech Certification
The distractions of modern technology seem inescapable. Articles, social media posts, and academic studies frequently condemn the attention-grabbing qualities of our phones and laptops--ironically, a problem we often read about and discuss on the very devices said to cause it.


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Robot Gets Up Close to the Seabed Without Disturbing It
Robot Gets Up Close to the Seabed Without Disturbing It
Seabed observation plays a major role in safeguarding marine systems by keeping tabs on the species and habitats on the ocean floor at different depths.




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Suicide and soap operas: North Koreans react to being Ukrainian POWs
Suicide and soap operas: North Koreans react to being Ukrainian POWs
The North Koreans showed up on the battlefield in late October, and have since earned a grim reputation among Ukrainians for apparently preferring to kill themselves rather than surrender.


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Southport attack: why is so much information being published only now?
Southport attack: why is so much information being published only now?
What were the missed chances to stop Rudakubana?Keir Starmer said unequivocally on Tuesday that the failure to prevent this attack "frankly leaps off the page".




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4 Things Apple Maps Does Better Than Google Maps
4 Things Apple Maps Does Better Than Google Maps
If you buy something using links in our stories, we may earn a commission. This helps support our journalism. Learn more. Please also consider subscribing to WIRED


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UK aims to fix government IT with help from AI Humphrey
UK aims to fix government IT with help from AI Humphrey
The UK government is striving to end its checkered record in managing large-scale projects with a "plan to put technology to work across public services.


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The global struggle over how to regulate AI
The global struggle over how to regulate AI
In March 2024, a Brazilian senator traveled on a commercial flight to Washington, D.C.


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These are the defining traits of the most fulfilling relationships, according to the longest scientific study of happiness
These are the defining traits of the most fulfilling relationships, according to the longest scientific study of happiness
In The Good Life: Lessons from the World's Longest Scientific Study of Happiness, Dr. Robert Waldinger and Marc Schulz, PhD, contrast the lives of two men: A teacher who had rich relationships with his friends, family, and students.


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How One Country Plans to Resettle Planeloads of Deportees from the U.S.
How One Country Plans to Resettle Planeloads of Deportees from the U.S.
Carlos Navarro was eating takeout outside a restaurant in Virginia recently when immigration officers apprehended him and said there was an order for his removal from the country. He had never had an encounter with the law, said Mr. Navarro, 32, adding that he worked at poultry plants.


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Poland fumes over US block on AI chips
Poland fumes over US block on AI chips
Mark Brzezinski, U.S. ambassador to Poland, was asked to explain the decision just before he left his post on Monday, the Polish ministry for economic development said in e-mailed remarks shared with POLITICO. Deputy Minister Michal Baranowski will also raise the issue during a trip to the U.S.


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Research analysts protest SEBI's new norms, some announce quitting the profession
Research analysts protest SEBI's new norms, some announce quitting the profession
SEBI-registered research analysts (RAs) are voicing their protest against the compliance requirements, particularly the ones that were released recently, and a few prominent names have announced their intention of winding up their services.


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Its a nightmare: couriers mystified by the algorithms that control their jobs
Its a nightmare: couriers mystified by the algorithms that control their jobs
Most days a thicket of couriers can be seen around the McDonald's in Northern Ireland's Ballymena, waiting for orders and discussing the mysteries of the systems that rule their working lives.


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Elon Musk to Get Terrifying Level of Access to Trump's White House
Elon Musk to Get Terrifying Level of Access to Trump's White House
Donald Trump has been president for less than a day, and Elon Musk already has a White House email address--and is expected to receive office space as well.


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Paris Olympics Medals Are Tarnishing, Putting LVMH in the Spotlight
Paris Olympics Medals Are Tarnishing, Putting LVMH in the Spotlight
Rarely in Olympic history had a single company been as ubiquitous as LVMH Moet Hennessy Louis Vuitton, the luxury goods empire owned by France's richest family. As the Paris Olympics' biggest corporate sponsor, LVMH was everywhere. Its Moet & Chandon champagne flowed in V.I.P. suites.


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'The Brutalist' AI backlash, explained
'The Brutalist' AI backlash, explained
Brady Corbert's The Brutalist is one of the most prominently featured films in this year's awards season, including widespread Oscar expectations of a Best Picture nod.


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Do All Democracies Have to Die?
Do All Democracies Have to Die?
Ancient thinkers believed that political systems, like people, had natural lifespans and that, like seasons, one type of system followed another in a predictable and unchanging cycle.


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Trump's science advisers: how they could influence his second presidency
Trump's science advisers: how they could influence his second presidency
For almost half of Donald Trump's first US presidency, which ran from 2017 to 2021, he did not have an official science adviser. His second term is shaping up to be different.


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The alcohol industry is hooked on its heaviest drinkers - WSJ (No paywall)
The alcohol industry is hooked on its heaviest drinkers
Heavier drinkers are obviously where the money is," said Philip Cook, a professor emeritus at Duke University whose 2007 book, Paying the Tab," was among the scientific studies analyzed by Bernstein.


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Dollar, bitcoin, treasury yields ease as investors weigh Trumps tariffs - WSJ (No paywall)
Dollar, bitcoin, treasury yields ease as investors weigh Trumps tariffs
The dollar fell against a basket of currencies, the yield on the 10-year Treasury eased and bitcoin pulled back from recent record highs in the wake of President Donald Trumps inaugural speech, with the absence of any immediate imposition of broad tariffs providing some relief to equities.


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Apples smartphone sales slump in China as Huawei gains market share - WSJ (No paywall)
Apples smartphone sales slump in China as Huawei gains market share
Apples smartphone sales in China fell sharply in the final quarter of 2024, hurt by the popularity of local rivals like Huawei and others expanding into the premium market, according to a closely followed research firm.


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Georgia Reports First Bird Flu Outbreak in Commercial Flock - Inc (No paywall)
Georgia Reports First Bird Flu Outbreak in Commercial Flock
This colorized electron microscope image released by the National Institute of Allergy and Infectious Diseases on March 26, 2024, shows avian influenza A H5N1 virus particles (yellow), grown in Madin-Darby Canine Kidney (MDCK) epithelial cells (blue). Photo: CDC/NIAID via AP, File


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To Fix Broken Work Systems, You Need to Reset - Harvard Business Review (No paywall)
To Fix Broken Work Systems, You Need to Reset
If youve ever tried to change things at work, you know the headwinds you face. Teams and processes are often trapped in longstanding, ineffective patterns that are hard to budge. Dan Heath, senior fellow at Duke Universitys Fuqua School of Business, explains proven techniques to reset. Those include making the problem visible, jolting incremental progress to start gaining traction, and motivating teams into a new direction. He shares real-life examples of how leaders and teams broke through seemingly intractable work situations. Heath is the author of the new bookReset: How to Change Whats Not Working.


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Trump And Melania Meme Coins Down 50% Since Weekend Peak - Forbes (No paywall)
Trump And Melania Meme Coins Down 50% Since Weekend Peak
A pair of crypto tokens launched by President Donald Trump and First Lady Melania Trump have dropped in value by more than 50% since their weekend peak, highlighting the volatile nature of so-called meme coinswhich several crypto executives warned could harm their industrys reputation.


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Canada has adopted assisted dying faster than anywhere on Earth - The Economist (No paywall)
Canada has adopted assisted dying faster than anywhere on Earth
Sandra Demontigny watched early-onset Alzheimers transform her athletic father from a robust patriarch into a battered shell of a man. Once the disease took hold, his untethered energy compelled him to walk into walls and crawl aimlessly along floors. He died aged 53, his face streaked with tears of frustration. When Ms Demontigny was diagnosed with the same, fatal neurodegenerative disease at 39, she vowed that she would not endure her fathers undignified death. Now she can take comfort in knowing she will not.


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Perella Weinberg feud goes to trial a decade after schism - FT (No paywall)
Perella Weinberg feud goes to trial a decade after schism
Tens of millions of dollars is at stake in dispute between elite investment bank and fired restructuring star Michael Kramer


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Managing AI agents as employees is the challenge of 2025, says Goldman Sachs CIO
Managing AI agents as employees is the challenge of 2025, says Goldman Sachs CIO
This year, artificial intelligence will be dominated by the maturation of AI code as corporate "workers" that can take over corporate processes and be managed just like employees, according to a year-outlook blog post disseminated by investment bank Goldman Sachs featuring its chief information of


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Vivek Ramaswamy responds to comments he left Trump's DOGE
Vivek Ramaswamy responds to comments he left Trump's DOGE
Vivek Ramaswamy has officially announced that he will no longer serve as co-leader of President Donald Trump's Department of Government Efficiency (DOGE), responding to comments about his departure on social media.


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Is Donald Trumps agenda actually popular?
Is Donald Trumps agenda actually popular?
Fearless journalism is more important than ever. When news breaks, you need to understand what actually matters and what to do about it. At Vox, our mission to help you make sense of the world has never been more vital. But we cant do it on our own.


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Oracle shares jump 7 on involvement in AI infrastructure initiative that Trump will announce
Oracle shares jump 7 on involvement in AI infrastructure initiative that Trump will announce
Last year Oracle picked up cloud business from artificial intelligence startup OpenAI, which needs large numbers of Nvidia graphics processing units to train and run AI models for its ChatGPT assistant and other products.


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Trump revives aremain in Mexicoa policy as part of anti-immigration crackdown
Trump revives aremain in Mexicoa policy as part of anti-immigration crackdown
This together with a policy of routine expulsions at the border under a heavily criticized pandemic rule ostensibly to curb Covid, known as title 42, has driven thousands to make unauthorized crossings, often repeatedly, and with deadly results for some - succumbing to botched smuggling businesses, the swirling waters of the Rio Grande in Texas or the desert there and further west.


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Mistral AI plans IPO | TechCrunch
Mistral AI plans IPO | TechCrunch
Mistral has raised around $1.14 billion in capital to date from investors including Andreessen Horowitz, General Catalyst, and Lightspeed Venture Partners. The company was reportedly last valued at around $6 billion.


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Perplexity launches Sonar, an API for AI search
Perplexity launches Sonar, an API for AI search
Perplexity on Tuesday launched an API service called Sonar, allowing enterprises and developers to build the startup's generative AI search tools into their own applications.


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Spotify's educational audio courses could be coming to U.S.
Spotify's educational audio courses could be coming to U.S.
Spotify is expanding its streaming service to now include educational courses in addition to music, podcasts, and audiobooks. The company on Tuesday referenced one of its newer features called courses, which allow users to learn about topics in areas like business, tech, lifestyle, music, and more.


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Undocumented Women Fear for Unborn Children After Trump's Birthright Citizenship Order
Undocumented Women Fear for Unborn Children After Trump's Birthright Citizenship Order
Ms. Calderas, who is from Guatemala, said Mr. Trump’s move stirred anxiety and uncertainty about the future of her family and especially her son. “It worries me that the new president doesn’t want to give citizenship to our baby,” she said. “This is where he will go to school and grow up. He will speak English like an American.”


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Trump Sued by Federal Employees Union Over Schedule F Order
Trump Sued by Federal Employees Union Over Schedule F Order
“The American people deserve to have day-to-day government services in the hands of qualified professionals who are committed to public service and stay on the job regardless of which political party holds the White House,” Doreen Greenwald, the union’s president, said in a statement.


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Panama Alerts United Nations to Trump's Inaugural Remarks
Panama Alerts United Nations to Trump's Inaugural Remarks
Starting late last year, Mr. Trump has repeatedly taken aim at Panama, falsely claiming that Panama has ceded control of the canal to China and that the United States must reclaim the strategic passageway.


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Elise Stefanik Pledges to Back Trump's Vision of a 'Reformed' U.N.
Elise Stefanik Pledges to Back Trump's Vision of a 'Reformed' U.N.
On several occasions, she also singled out the U.N. Relief and Works Agency, which is known as UNRWA and serves Palestinian refugees in Lebanon, Jordan, Syria, the Palestinian Territories and East Jerusalem, as too deeply infiltrated by Hamas to deserve U.S. support. U.N. investigators recently investigated allegations that some of its employees were involved in the Hamas-led attack on Israel on Oct. 7. 2023, and fired several people who were accused of participating.


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Tech leaders praise Trump's rollback of Biden's 'AI red tape'
Tech leaders praise Trump's rollback of Biden's 'AI red tape'
“This critical legislation would ensure no future President or bureaucrats can coerce social media sites to suppress lawful American speech,” Robert Winterton, NetChoice vice president of public affairs, said in a statement.




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