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Editor's Pick
New Insight into Genetic Disease Variability - Neuroscience News
 Summary: New research reveals that certain cells inactivate one parent’s copy of a gene, leading to a bias in gene activity that may explain why some individuals with disease-causing mutations remain symptom-free. This selective gene inactivation, known as monoallelic expression, affects about 1 in 20 genes and varies between cell types.
Enlisting an international team of collaborators, the researchers looked at several families with different genetic disorders affecting their immune systems. In each case, the disease-causing copy was more likely to be active in sick patients and suppressed in healthy relatives who had inherited the same genes.
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Editor's Note: So in some cells in your body every 20th gene can be a little bit more Mom, a little bit less Dad, or vice versa. And to make thing even more complicated, this can be different in white blood cells than in the kidney cells, and it can perhaps change with time.
WorkWorkIt's Official: Boring Cities Are Bad for Your Health A significant proportion of people today live in towns and cities that grew up around trade, industry, and cars. Think of the docks of Liverpool, the factories of Osaka, the automobile obsession of New York's Robert Moses, or the low-density sprawl of modern Riyadh.
WorkWorkCreating new utopias in Portugal - FT (No paywall) The country has long attracted creatives and entrepreneurs looking for a different way of living. Now, a clutch of pioneers is reimagining agricultural sites as new communities that speak to a yearning for reconnection
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WorkScam Recruiters Are Hiring for Your Company. Here's How to Fight Back - Inc (No paywall) Jenny Battershell knows when her employer, Goodwin Recruiting, has been hit with another hiring scam. As the director of marketing, she monitors site traffic, and when a new scam rears its head, visits jump upwards of 1,500 percent. Then comes the deluge of texts and emails from job seekers asking if the cold messages theyve received from Goodwin recruitersvia text, WhatsApp, or LinkedInare legitimate. WorkWhy An Old-School Value Investor Is Betting On Bitcoin - Forbes (No paywall) My first trip to Las Vegas is one I remember very fondly. I was only about a year out of college when my best friend offered me a free flight to go with him for a few days. We stayed at the Hard Rock Casino, which was off the Strip at the time and exactly the kind of place where someone my age would want to be at with its party-like atmosphere, smaller and more intimate table gaming pit than the bigger casinos on the Strip, and some of the most generous comps.
WorkTrump has faced down Republican dissidents in Congress - The Economist (No paywall) REPUBLICANS ON CAPITOL HILL have a reputation for infighting and not getting much done. January 3rd, the first day of the 119th Congress, featured plenty of infighting. Surprisingly, the House GOP also managed to get something donethe formerly simple process of electing their leader. Yet the uneasy victory of Mike Johnson, the House speaker, looks tame compared with the legislative fights to come. WorkDo Insects Feel Pain? - The New Yorker (No paywall) One of the stranger effects of Brexit was that, after the United Kingdom left the European Union, in 2020, it no longer recognized animals as sentient beings. When the U.K. was an E.U. member state, it was bound by European laws, including the Lisbon Treaty, which invoked sentience in order to shield animals from sensations such as pain, hunger, and fear. But, after Brexit, the U.K. was no longer subject to the treaty. Numerous advocacy groups demanded a replacement animal-sentience law. Twenty-nine leading veterinarians, who treated cattle, birds, fish, dogs, and other animals, sent a letter to the Daily Telegraph. Scientific evidence demonstrates the ability of animals across a range of species to have feelings, they wrote. We have fought for legislation that places a duty on the state to recognise this.
WorkWorkHow Florida's population is set to change by 2030 Florida will remain one of the most populous U.S. states in 2030 with more than a quarter of its residents expected to be aged 65 and over, according to projections from the University of Virginia's Weldon Cooper Center for Public Service.
WorkWorkHillary Clinton Receives the Highest U.S. Civilian Honor WASHINGTON In the East Room of the White House on a particularly frigid Saturday afternoon, President Joe Biden bestowed the Presidential Medal of Freedom to 19 of the most famous names in politics, sports, entertainment, civil rights, LGBTQ+ advocacy and science.
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WorkMusk says Farage 'doesn't have what it takes' to be Reform UK leader Elon Musk has called for Nigel Farage to be replaced as leader of Reform UK, just weeks after it was claimed the multi-billionaire was in talks to donate a large sum to the party. In a post on his social media site X, Musk said Farage "doesn't have what it takes" to lead the party. WorkWorkWorkA Novel to Help You Slow Down Culture and entertainment musts from Kristen V. Brown This is an edition of The Atlantic Daily, a newsletter that guides you through the biggest stories of the day, helps you discover new ideas, and recommends the best in culture. Sign up for it here. WorkWorkWorkWorkWorkWorkAI Agents In 2025: What Enterprise Leaders Need To Know "2025 will be the year of the AI agent." Wait -- didn't we already say that in 2023? Back then, I talked about chaining AI models in my podcast. The excitement around AI was huge, and by 2024, many companies rushed to try generative AI, with some even using chained models. WorkWorkWorkHow datacenters use water and why kicking the habit is nearly impossible Feature The explosive growth of datacenters that followed ChatGPT's debut in 2022 has shone a spotlight on the environmental impact of these power-hungry facilities. But it's not just power we have to worry about. These facilities are capable of sucking down prodigious quantities of water. WorkWorkWorkWorkWorkThe Secret Lab Hidden Inside a Famous Monument The Monument is one of London's most famous landmarks, even giving its name to a local Tube stop. But this tribute to London's greatest fire also has a secret second use - as a giant piece of scientific equipment. WorkWorkWorkWorkWorkWorkCalifornia Police Department Agrees to Reforms After Federal Inquiry In the messages, officers used racist slurs to describe Black people, bragged about the use of force and, during the protests in 2020 in response to the murder of George Floyd at the hands of police officers, used slurs against Mr. Floyd and mocked the public outrage against racism in law enforcement. WorkWorkWorkWorkIn Reversal, Musk Trashes Farage, U.K.'s Anti-Immigrant Populist Mr. Musk’s rupture with Mr. Farage was a new twist in the days-long barrage of increasingly strident, misinformation-filled posts about Britain from Mr. Musk, who appears intent on exercising the same influence in European countries that he did during the American presidential election. WorkUnited will start testing Starlink on flights in February Starlink has expanded in some serious ways in the last year. SpaceX got to test Starlink's direct-to-cell satellite service with T-Mobile during Hurricane Milton's landfall in the US, made plans for a larger beta test of the service for February and launched a nationwide satellite texting service in New Zealand. WorkWorkWho really gets the H-1B visas Elon Musk is fighting about? H-1B visas also allow international students graduating from US medical schools to stay in the country and work in hospitals or clinics in underserved and often remote or rural areas, Batalova said, places incidentally "where American workers will not go." WorkWork TradeBriefs Publications are read by over 100,000 Industry Executives About Us | Advertise | Privacy PolicyUnsubscribe (one-click) You are receiving this mail because of your subscription with TradeBriefs.
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