A message from our President and Chief Executive Officer


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Dear Friend,

This year, we continued to transform all areas of our work to help people with cystic fibrosis. Here are some exciting highlights that community members like you made possible. I could not be more grateful, and I hope you feel proud of all that we've accomplished together in support of our shared mission.

# Hallmarks of Excellence in 2024

* Expanded our genetic therapies pipeline to roughly a dozen programs, with six already in early-stage clinical trials
* Celebrated FDA approval of a new once-a-day modulator, Alyftrek (vanzacaftor/tezacaftor/deutivacaftor), for people with CF ages 6 and older who have CFTR mutations that are eligible for Trikafta, as well as 31 additional rare mutations that have not been approved previously for any other CFTR modulator
* Supported the FDA's expansion of Trikafta (elexacaftor/tezacaftor/ivacaftor) to people with CF ages 2 and older who have at least one of 94 additional rare CFTR mutations
* Continued to deliver state-of-the-art CF care by funding a national network of CF care centers, while further evolving our CF care model to best meet the diverse needs of a growing CF adult population
* Appointed Albert Faro, MD as the Foundation's new chief medical officer to guide excellent clinical care delivery into the next era of CF
* Supported clinical trials around the world and invested millions in research to address drug-resistant infections, CF-related diabetes, advanced lung disease, and other health complications of this disease
* Worked to ensure that people with CF from all backgrounds receive the best possible care by investing in research to treat the full range of CFTR mutations, increasing access to clinical trials through new enrollment practices, and improving newborn screening guidelines so that every baby born with CF in the U.S. can be diagnosed early
* Helped nearly 4,000 CF families navigate financial, insurance, access, legal, and other issues associated with living with CF through Compass, saving the community a projected $3 million
* Partnered with dedicated donors and volunteers, raising close to $100 million in fundraising revenue to speed progress and raised more than $185 million toward the $200 million goal of our Milestones III fundraising campaign
* Collaborated with community members by connecting at hundreds of events nationwide, advocating for beneficial legislative policies, and developing community programs that best support all people with CF and their families no matter where they are on their unique journey



As we look to the future, we have so much to celebrate. At the same time, we share the sense of urgency that many CF families feel every day as they await new scientific breakthroughs. We stand resolute in our commitment to do all we can for people with CF. Together, I know we will cure cystic fibrosis.


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Have a safe and happy holiday season,

Michael P. Boyle, MD

President and CEO

Cystic Fibrosis Foundation


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4550 Montgomery Avenue, Suite 1100N | Bethesda, MD 20814 US


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