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- The top 25 stories curated by editors and fellow readers!

Editor's Pick

Cambridge researchers develop urine test for early detection of lung
cancer | University of Cambridge

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scientists have developed a urine test for early detection of lung
cancer. The test, the first of its kind, detects "zombie" cells that
could indicate the first signs of the disease.

Continued here
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Editor's Note: Lung cancer has a poor prognosis for many patients
because often there are no noticeable symptoms until it has spread
through the lungs or into other parts of the body. The new urine test
will allow doctors to spot the disease before it develops.

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Suspect in Killing of Insurance C.E.O. Is Said to Have Used Fake New
Jersey ID
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The authorities released two images that they said showed the face of
the man they believe fatally shot the chief executive of one of the
largest health insurers in the country.

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Why 597 million chickens go missing from America?s food supply each
year
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If you believe in the work we do at Vox, please support us by becoming
a member. Our mission has never been more urgent. But our work isn?t
easy. It requires resources, dedication, and independence. And that?s
where you come in.















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Can Russia still save Assad in Syria?
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Just when it seemed he had consolidated his position as Syrian
president after the Arab Spring uprising and Islamic State land grabs,
Bashar al-Assad's future hangs in the balance after a stunning advance
by anti-regime forces, who seized control of key cities.

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How to Build a General-Purpose LLM Agent
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Why build a general-purpose agent? Because it's an excellent tool to
prototype your use cases and lays the groundwork for designing your
own custom agentic architecture. Before we dive in, let's quickly
introduce LLM agents. Feel free to skip ahead.














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The Immigrants Most Vulnerable to Trump's Mass Deportation Plans
Entered the Country Legally - The New Yorker (No paywall)
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One afternoon, in November, 2022, Emily was on her way to church, in
Maracaibo, Venezuela, when she received a video call from her husband.
It had been two years since they'd seen each other in person. He was a
policeman who had fled the country after refusing to arrest
pro-democracy demonstrators. Emily and their two children, who were
seven years old and eleven months old, had stayed behind. Travelling
north was expensive, and the journey would have taken the family
through the dangerous jungle of the Dari

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Bird Flu Virus Is One Mutation Away from Binding More Efficiently to
Human Cells - Scientific American (No paywall)
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A new study finds tweaking part of the H5N1 virus infecting dairy cows
in a single spot could allow it to better attach to human cell
receptors, raising concerns it could transmit more easily between
people














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Academic trolled for PhD 'unfazed by the vitriol'
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An academic who received death and rape threats after posting a
picture of herself on X with her completed PhD has said she feels
"quite unfazed by the vitriol".

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France steps into deep trouble - The Economist (No paywall)
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ON DECEMBER 7th, 50 heads of state and government will take their
places to celebrate the reopening of Notre Dame, Paris?s 12th-century
Gothic cathedral, gutted by fire five years ago but now restored with
astonishing speed and loving skill. Donald Trump will be there (Joe
Biden, only the second Catholic president of America, sadly will not)
to witness France at its best. It has pulled off, on time and to
budget, a feat of craftsmanship and renewal that surely no other
country could have managed.














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The 70% problem: Hard truths about AI-assisted coding
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After spending the last few years embedded in AI-assisted development,
I've noticed a fascinating pattern. While engineers report being
dramatically more productive with AI, the actual software we use daily
doesn't seem like it's getting noticeably better. What's going on
here?

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PulseNet identifies and stops foodborne illness outbreaks. Health care
needs something similar - STAT (No paywall) [[link removed]}&lead=419599&emailid=106598&nl=daily]
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The recently ended Boar?s Head listeria outbreak, which has caused 57
infections and nine deaths, is just one of the many foodborne illness
incidents that the Centers for Disease Control and Prevention detects
each year using its PulseNet system. Many people might not realize the
extensive effort behind PulseNet, which systematically collects data
on foodborne illnesses from patients across the U.S., performs genomic
fingerprinting, and traces outbreaks back to their sources. This
network of surveillance has been alerting the public to foodborne
outbreaks and recalls for years.














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Your Stress Could Be Stressing Out Your Dog
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New research suggests that a person's stress levels could directly
impact their dog. The study, conducted by researchers at Queen's
University, Belfast (QUB), found a potential correlation between a
dog's stress levels and its owner's stress levels.

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Trump picks Musk ally David Sacks as crypto and AI tsar
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Ex-PayPal executive and VC investor hosted Silicon Valley fundraiser
for president-elect














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As Greenland's Ice Sheet Melts, an Island Town Rises
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Geologists are working with local communities to determine how
residents can adapt as the area's sea level, in effect, goes down

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The Year of the Underconsumer
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Frugality got a glossy rebrand in 2024.














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Your Internet Shouldn't Be My Internet
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I deleted my Instagram a few weeks ago. It felt like the most
difficult platform to give up in my quest to redefine my relationship
to the internet and reduce the time I spent doomscrolling.

Work

The 10 Best Yoga Poses To Do Every Day, According To The Pros
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No hour-long flow needed.













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Designing a Shared Use, Incubator, or Commissary Kitchen
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The shared kitchen industry continues to grow. Pandemic disruptions, a
surge in delivery platforms, and the daunting hurdles of escalating
construction costs and labor shortages have resulted in a dramatically
altered landscape.

Work

Why Prepping for End Times Is So American
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Millions are preparing for doomsday, not together, but by closing the
hatch. It's a logical response to a hollowed-out state.

Work

Is the Dunning-Kruger effect real?
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This is an abridged, less technical version of our longer report,
found here. You've probably heard that people who are bad at something
tend to overestimate how skilled they are. They don't even know enough
to know how bad they are.

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Why did clothing become boring?
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One of the reasons I'm a historian is that I find the strangeness of
the past to be underrated. You can find something deeply,
fascinatingly weird about virtually any aspect of any human culture
prior to around the year 1880, provided you take the time to dig into
it.

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The Future of B2B Marketing: 11 Predictions for 2025, From New
Playbooks to Strategic Brands and AI Agents
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In 2006, we founded Marketo and I helped create the traditional B2B
marketing playbook--the one built on MQLs, marketing automation, and
measuring everything. For years, it worked brilliantly. Marketing
finally had a seat at the revenue table, with clear metrics and
predictable processes.

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Congo government says it's 'on alert' over mystery flu-like disease
that killed dozens
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Congo's health minister said Thursday the government is on alert over
a mystery flu-like disease that in recent weeks killed dozens of
people, nearly half of which were children.

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What It's Like to Live in the World's Most Innovative Countries
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The BBC speaks to residents and travellers in some of the top-ranked
countries on the 2024 Global Innovation Index to find out how
cutting-edge technology benefits day-to-day life.

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Ukraine gave up its nuclear weapons. Now it's asking why
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Under heavy grey skies and a thin coating of snow, hulking grey and
green Cold War relics recall Ukraine's Soviet past.

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How Epic?s 81-Year-Old Billionaire Founder Plans To Keep Her Health
Data Empire Private Forever - Forbes (No paywall)
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Judy Faulkner takes the stage at Epic System?s annual customer
meeting, trailed by a 6-foot tall plastic swan boat that requires two
human handlers. Seven thousand healthcare industry executives titter
in befuddled amusement wondering why the founder and CEO of a company
with $4.9 billion in annual revenue, whose medical records software is
used for 325 million patients worldwide, is sporting a wreath of white
feathers around her neck and several more from a plume atop her head.
Faulkner says it?s her modern spin on one of the world?s great
storytellers: instead of Mother Goose, she calls herself ?Lady Swan.?

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Microbiome interventions for children raise the ethical stakes
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When she had her daughter in 2008, microbiologist Deanna Gibson rarely
saw probiotics in the baby formula on supermarket shelves. "Then when
I had my son in 2012, it was pretty much in every formula," recalls
Gibson, who is at the University of British Columbia in Kelowna,
Canada.

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Why housing shortages cause homelessness
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Diona's mom gave her one week's notice. There were too many kids and
too little space. If 17-year-old Diona didn't find someone to stay
with, she would be forced to check herself and her 3-month-old son
into a homeless shelter.

Work

Bernie Sanders Says RFK Jr.?s Comments On Food Industry ?Exactly
Correct? But Health Views ?Extremely Dangerous? - Forbes (No paywall)
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Sen. Bernie Sanders, D-Va., backed Robert F. Kennedy Jr.'s comments on
the food industry, in an interview with CBS News on Thursday, but
stopped short of committing to approve his nomination as Health and
Human Services Secretary, citing concern about his views on other key
health issues.

Work

OpenWeb's ousted CEO who refused to quit speaks exclusively with BI
about his battle with the board
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Nadav Shoval says the conflict that culminated in his dramatic ouster
from OpenWeb, the company he cofounded, started with a disagreement
over a potential BlackRock investment.

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Emmanuel Macron to Name New French PM Within Days
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French President Emmanuel Macron has rejected calls to stand down amid
a political crisis that has seen his prime minister ousted in a
no-confidence vote. In an address following Michel Barnier's
resignation, Macron said that his mandate was one of five years that
he would see through to the end.

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Franco-German Fight Over South American Trade Deal Threatens EU
Rupture
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Ursula von der Leyen granted the wish of her native Germany by flying
off to seal an accord with the Mercosur bloc. France, which fiercely
opposes the deal, is in uproar.

Work

Life Is One Long Intelligence Test
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This is part of a series, of people, who have contributed
significantly to their field. Whilst they are known within the field,
rarely are they known outside the field or widely, yet should be. See
below for others. I keep a note on my desk; "memory is all we have".

Work

Insurance companies like United Healthcare are not the only ones to
blame for a broken system
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Brian Thompson was an advocate for universal coverage through private
insurance.  I have argued here and elsewhere that better policy,
including effective regulation, should make that possible. Perhaps, if
we can begin to make affordable, accessible, high-quality health care
a reality for everyone, fewer people will feel excluded, disrespected,
uncared for — and angry.

Work

PulseNet identifies and stops foodborne illness outbreaks. Health care
needs something similar
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Alexander Sundermann is an assistant professor of epidemiology at the
University of Pittsburgh, School of Public Health. He studies how to
detect and mitigate health care outbreaks using genomic surveillance
and infection prevention innovations.

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Inside a Nobel-winning marriage: They see each other as scientific
equals, even if the prize committee doesn't
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Inspired, Ambros and Lee launched their own search, and by spring the
following year had unearthed a dozen more microRNAs. The discovery had
them riding high through the summer, as they took trips to their
country house and cheered from the sidelines at their teenage sons’
baseball and soccer games. Then came the email from the editor.

Work

NYC Mayor Eric Adams Takes Victory Lap: 'Remember Y'All Laughed When I
First Got My Bitcoin? Who's Laughing Now?'
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It’s no wonder Jeff Bezos holds over $70 million in art — this
alternative asset has outpaced the S&P 500 since 1995, delivering an
average annual return of 11.4%. Here’s how everyday investors are
getting started.

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Sundar Pichai says Google Search will 'change profoundly' in 2025
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Google CEO Sundar Pichai says the company's search engine will "change
profoundly" in 2025. "I think we are going to be able to tackle more
complex questions than ever before," Pichai said during the NYT's
DealBook Summit on Wednesday.

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Meet the Unstoppable Artificial Intelligence (AI) Stock That Could
Join Apple, Nvidia, and Microsoft in the $3 Trillion Club by 2028
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Randi Zuckerberg, a former director of market development and
spokeswoman for Facebook and sister to Meta Platforms CEO Mark
Zuckerberg, is a member of The Motley Fool's board of directors. Adam
Levy has positions in Apple, Meta Platforms, and Microsoft. The Motley
Fool has positions in and recommends Apple, Meta Platforms, Microsoft,
and Nvidia. The Motley Fool recommends the following options: long
January 2026 $395 calls on Microsoft and short January 2026 $405 calls
on Microsoft. The Motley Fool has a disclosure policy.

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Why Jumia Stock Skyrocketed Today
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Stock Advisor provides investors with an easy-to-follow blueprint for
success, including guidance on building a portfolio, regular updates
from analysts, and two new stock picks each month. The Stock
Advisor service has more than quadrupled the return of S&P 500 since
2002*.

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Analysis-Gas price shock set to add to Europe's industrial pain
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(Reporting by Forrest Crellin, Nora Buli and Nina Chestney; additional
reporting by Christoph Steitz in Frankfurt, Jesus Calero in Gdansk and
Mark John in London; Writing by Nina Chestney; Editing by Barbara
Lewis)

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Teaching Elderly People to Use Android - Lessons Learned
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This is my story about an adventure into online teaching, video course
making, and choosing a hard-to-reach audience, who desperately needs
help.

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GameStop-Themed Memecoins Explode As Roaring Kitty Returns With
Intriguing X Post: GME Coin Shoots Up Over 80%
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CEO of Integris gathered a team of senior investment managers who have
$34.22 billion in combined owned and managed assets in the West Coast
— here’s how to invest in their private credit fund that targets
12% annual interest rate.

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Jensen Huang Just Announced Bad News for Nvidia's Rivals
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Nvidia (NASDAQ: NVDA) is in a position any chip designer would envy.
The company dominates the high-growth artificial intelligence (AI)
chip market, and this leadership has helped bring Nvidia triple-digit
revenue growth in recent quarters, along with soaring share
performance. This top chip company has its share of competitors, from
other chip designers like Advanced Micro Devices and Intel to its own
customers -- due to their in-house chip projects.

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The Doomsday Trade: These 3 Assets Could Skyrocket if WW3 Breaks Out
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RISK OF INVESTING. Investing is inherently risky. Do not trade with
money you cannot afford to lose. There is a real risk of loss
(including total loss of investment) in following any strategy or
investment discussed in this article or on our website. This is
neither an offer to purchase, nor a solicitation of an offer to sell,
subscribe for or buy any securities or the solicitation of any vote in
any jurisdiction. No representation is being made as to the future
price of securities mentioned herein, or that any stock acquisition
will or is likely to achieve profits.

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Here's What OpenAI's $200 Monthly ChatGPT Pro Subscription Includes
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Earlier today, OpenAI launched ChatGPT Pro, a $200 monthly
subscription for its flagship chatbot. This release is the first of
many expected during the next 12 days, as the San Francisco startup
has scheduled a slew of announcements to roll out starting today.

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Billionaire Steven Cohen Sold Point72's Entire Stake in Supermicro and
Is Piling Into This Game-Changing Artificial Intelligence (AI) Stock
Instead
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Billionaire Steven Cohen Sold Point72's Entire Stake in Supermicro and
Is Piling Into This Game-Changing Artificial Intelligence (AI) Stock
Instead was originally published by The Motley Fool

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OpenAI's o1 model sure tries to deceive humans a lot | TechCrunch
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Behind the releases of big new AI models, there’s a lot of work that
OpenAI does internally to measure the safety of its models. Reports
suggest there’s a proportionally smaller team at the company doing
this safety work than there used to be, and the team may be getting
less resources as well. However, these findings around o1’s
deceptive nature may help make the case for why AI safety and
transparency is more relevant now than ever.

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MobiKwik's IPO will value it at $250M, 73% less than its last private
valuation | TechCrunch
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The 15-year-old startup operates one of the most widely used mobile
wallet apps in India. But it has struggled to maintain relevance after
a government-backed protocol, UPI, saw broader adoption. The company
has raised more than $268 million to date.

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How Shopping Malls Are Being Transformed Into Apartments In The U.S.
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While many U.S. malls face anchor store closures and empty parking
lots, some are finding new life by becoming housing. Real estate
developers are building housing inside of or next to shopping malls as
department stores like Macy's, JCPenney and Sears shrink or cease to
exist. At least 192 U.S. m

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Senior Biden aide commits to giving Ukraine avalanche of military
assistance
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These meetings carry heightened urgency, particularly after House
speaker Mike Johnson blocked a vote on $24bn in additional aid to
Ukraine. The Pentagon has nonetheless committed to sending $725m in
military assistance this week, the largest shipment since April.

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California school shooter identified as police call childrena??s
survival a??miraclea??
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"Here we are again in Butte county dealing with another major
incident, major tragedy," Honea said. "This community has endured so
much in the last three years, it's hard to believe we're back here
again."

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Biden wishes US a??light of libertya?? during last White House
Christmas tree lighting
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That tree came from a farm in Newland, North Carolina, where Hurricane
Helene struck earlier this year. The Cartner's Christmas Tree Farm,
which had stood for decades, lost thousands of trees to a mudslide.

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Trump picks venture capitalist David Sacks as AI and crypto a??czara??
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Rodney S Scott, the former chief of the US Border Patrol and a
border-wall advocate, was picked for US Customs and Border Protection
commissioner. Caleb Vitello, who currently serves as assistant
director of the Office of Firearms and Tactical Programs was selected
as acting director of Immigration and Customs Enforcement (Ice).

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Average UK house price hits record A?298,083, says Halifax
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"Homes that are well-priced and well-presented continue to sell
relatively quickly. Buyers may pause to assess the financial
implications of a purchase but high-demand areas are likely to retain
interest into the new year and beyond."

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Struggling Thames Water receives A?5bn buyout offer from Covalis
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Existing investors in Thames Water, which include the pension funds
Omers and USS, as well as Chinese and Abu Dhabi sovereign wealth
funds, have said they believe the business is "uninvestable".

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Keir Starmer dismisses approval ratings slump, saying a??all that
mattersa?? is delivering change by next election a?? UK politics live
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I find it very helpful when readers point out mistakes, even minor
typos. No error is too small to correct. And I find your questions
very interesting too. I can't promise to reply to them all, but I will
try to reply to as many as I can, either BTL or sometimes in the blog.

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Sale of the Observer to Tortoise Media agreed in principle
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Lambert said: “The Observer matters. In a noisy marketplace, it has
an independent and progressive voice, covering ideas and stories that
don’t get proper attention elsewhere. Its editorial comments are
shaped by its journalists rather than by other interests. These values
must be supported, and I’m keen to do anything I can to help.”

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National Rail says a??nationwide faulta?? disrupting trains across
Britain a?? live updates
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National Rail advised that trains across the network are having to
start journeys later because "of a nationwide fault with the onboard
'GSMR radio system that allows communication between train drivers and
signal operators"

Work

Dona??t expect better public services a??by Christmasa??, Starmer says
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Matthew Pennycook, the housing minister, sought to defuse the row on
Friday morning, telling LBC Radio: "We have to take the civil service
with us on a journey to do government in a slightly different way â¦
I haven't experienced any particular civil servant in a tepid bath of
declinism - they share our ambition."

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Middle East crisis live: thousands flee Homs in central Syria as rebel
forces push on
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Russian foreign minister, Sergei Lavrov, has said that he plans to
hold talks on Friday with Turkish and Iranian officials on the
situation in Syria. On Thursday, Lavrov said Moscow was “very much
concerned” with a recent escalation of violence in Syria.

Work

Marles rejects Netanyahua??s criticism of Australian governmenta??s UN
vote on Palestine
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"There are in fact many resolutions in the UN around Israel and
Palestine. In terms of how we vote in the whole suite of those, we do
so really trying to give expression to a view that we very much
support Israel, but we support a two-state solution and that
ultimately does mean the establishment of a Palestinian state," he
told Radio National.

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