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- The top 25 stories curated by editors and fellow readers!

Editor's Pick

Why Are Start-Ups Losing So Much Money? - American Affairs Journal

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losses for today’s start-ups are much more common than they were
decades ago, and the losses are much bigger. VCs are making back less
from their initial investments than at any point since the global
financial crisis of 2007–9. According to a study by Jay Ritter, only
22 percent of start-ups were profitable in 2021, the year of peak
IPOs, versus 80 percent in the early 1980s. And today’s start-ups
are not...

Continued here
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We carefully curate these stories to keep you informed and save you
time.

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Send us an email to let us know how we can make this newsletter even
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The Opposition to Trump Has Never Been This Deflated
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Around this time eight years ago, a whole lot of time went into
cobbling together what would come to be known as The Resistance. As
the countryand the world, reallystarted to come to understand the
incoming Trump administrations plans, an unlikely cooperative of
folksfeminists, scientists, immigration activists, traditional
Republicansfound common ground in their shared sense of dread. On the
first full day of Donald Trumps presidency, the amalgam responded with
a national day of protest that, to that point, had no peer.

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14 Subtle Ways Having A Toxic Parent Affects You As An Adult
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Certain traits that come out in adulthood can be signs that your
parents were toxic as a kid.















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Biden proposes massive expansion of US weight-loss drug coverage - FT
(No paywall) [[link removed]}&lead=419599&emailid=101000&nl=daily]
State-backed insurance programmes would fund drugs for obese patients
without separate health conditions

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A Revolution in How Robots Learn - The New Yorker (No paywall)
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In the first days of my sons life, during the fall of 2023, he spent
much of the time when he wasnt sleeping or eating engaged in what some
cognitive scientists call motor babbling. His arms and legs wiggled;
his eyes wandered and darted, almost mechanically. One night, as he
was drifting off to sleep, he smiled for the first time. As I admired
him, wondering what he might be thinking about, his expression
suddenly went blankand then, in quick succession, he looked upset,
then surprised, and then happy again. It was as if the equipment were
being calibrated. That is apparently the purpose of motor babbling:
random movements help the brain get acquainted with the body its in.














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Roche's TIGIT troubles continue, a novel Alzheimer's target misses the
mark, and other biotech news - STAT (No paywall)
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Speaking of Turkey Day, in the 1970s, my paternal grandparents lived
on Central Park West in NYC. They had a view of the parade route from
their apartment balcony. One of my most cherished childhood memories.

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The Makers of Phony Negroni Are on Track to Sell 2 Million Bottles
This Year. How the Nonalcoholic Spirits Industry Is Coming of Age -
Inc (No paywall) [[link removed]}&lead=419599&emailid=101000&nl=daily]
About a decade ago, Louis and Matt Catizone noticed that amaroa
bitter, herbal spirit they associated with their familys Sunday dinner
tablehad been discovered by negroni-sipping hipsters in Brooklyn, New
York.














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Drake-Kendrick Lamar Feud Timeline: Drake Claims Universal Music
Artificially Inflated Not Like Us Spotify Streams - Forbes (No
paywall) [[link removed]}&lead=419599&emailid=101000&nl=daily]
Drake took his long-running, highly dramatic feud against Kendrick
Lamar to the courts Monday, alleging in a filing Universal Music Group
artificially inflated streams of Lamars hugely successful diss track
aimed at Drake, Not Like Us, which the label deniedjust days after
Lamar surprise-dropped a new album that references the feud.

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U.S. airlines collected more than $12 billion from seat fees - WSJ (No
paywall) [[link removed]}&lead=419599&emailid=101000&nl=daily]
Five U.S. airlines collected $12.4 billion from such charges from 2018
to 2023, according to the report. Checked bags-the airlines biggest
source of revenue beyond tickets themselves-brought in about $25
billion over that stretch for those carriers.














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Starbucks, other retailers hit by ransomware attack on tech provider -
WSJ (No paywall) [[link removed]}&lead=419599&emailid=101000&nl=daily]
A ransomware attack against a major supply chain technology provider
left retailers including Starbucks and U.K. grocery chain Sainsburys
scrambling to manage operations including scheduling and handling
inventories.

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Fitch Ratings says it may cut some Adani Group bonds to junk status -
WSJ (No paywall) [[link removed]}&lead=419599&emailid=101000&nl=daily]
Fitch Ratings may cut some Adani Group bond ratings to speculative
territory after billionaire founder Gautam Adani was charged by the
U.S. Justice Department in a bribery scheme.














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Musk wants $2 trillion of spending cuts. Heres why thats hard. - WSJ
(No paywall) [[link removed]}&lead=419599&emailid=101000&nl=daily]
The U.S. federal government spent $6.75 trillion in the most recent
fiscal year ended Sept. 30, according to the Congressional Budget
Office. Walk around town handing $20,000 to everyone you see. Now do
that for the entire U.S. population, all 337 million of us. That is
about how much the U.S. spent.

Work

US New-Home Sales Slump to Two-Year Low After Storms in South -
Bloomberg (No paywall) [[link removed]}&lead=419599&emailid=101000&nl=daily]
Sales in South fell 28% in October to slowest pace since 2020 Rising
mortgage rates and high prices also dragged down sales














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How the World Gave up on 1.5 Degrees
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A decade after the Paris Agreement, Andreas Malm and Wim Carton trace
how we've kept on with business as usual.

Work

"No debate" that charges against Trump "constitute crimes": Ex-Trump
lawyer
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President-elect Donald Trump's former White House lawyer said on
Monday that there's "no debate" that the allegations in the special
counsel Jack Smith's election subversion case against Trump
"constitute crimes."














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Could tweaks to the tax code lead to more marriages and more kids?
[[link removed]}&lead=419599&emailid=101000&nl=daily]
Our mission could not be more clear and more necessary: We have a duty
to explain what just happened, and why, and what it means for you. We
need clear-eyed journalism that helps you understand what really
matters. Reporting that brings clarity in increasingly chaotic times.
Reporting that is driven by truth, not by what people in power want
you to believe.

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Thiago Messi following in father Lionel's footsteps
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When your father is hailed as one of the greatest footballers to ever
grace a pitch, there is a high likelihood you will follow in his
footsteps, right? Well, that appears to be the path that Thiago Messi,
the son of eight-time Ballon d'Or winner Lionel, is taking.













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Man Convicted for Gaining 44 Pounds To Dodge Military Duty
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A South Korean man has been handed a suspended prison sentence after
intentionally gaining over 44 pounds to avoid a more demanding
position under the country's military conscription system, a Seoul
court announced Tuesday.

Work

Sudden Panic Sparks $200 Billion Bitcoin And Crypto Price Crash
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Bitcoin and crypto prices have crashed following their huge rally on
the back of Donald Trump's U.S. election victory (despite Elon Musk
quietly confirming a crypto market game-changer).

Work

China Says No One Will Win A Trade War After Trump Tariff
Announcement--Asian Stocks Hit
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Chinese Embassy officials in the U.S. warned Monday that a trade war
between the two countries would have no winners, after President-elect
Donald Trump reiterated his plans to impose additional tariffs on
Chinese imports.

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China defends Mexico trade after Trump pledges fresh tariffs
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Cars and containers at Mexico's port of Lazaro Cardenas. China says
its products have "played an important role in the development of
Mexico's manufacturing industry and enhanced its trade
competitiveness." (C) Reuters

Work

Apple designed the iPhone 17 Slim so thin, it cannot hold a SIM card,
won't have mmWave
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Apple is pushing the boundaries of smartphone design with the upcoming
iPhone 17 Slim, also referred to as the iPhone 17 Air. This device,
rumoured to be just 6mm thick, is set to be one of the thinnest
smartphones ever made.

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Gavin Newsom Sparks Anger With Proposed Tesla Move: 'Insane'
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Tesla CEO Elon Musk has reacted with fury to reports that California
Governor Gavin Newsom could exclude his company from a state-funded
electric vehicle tax credit program.

Work

Couple Charged In Ring Suspected Of Stealing $1 Million In Lululemon
Clothes
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MINNEAPOLIS (AP) -- A Connecticut couple has been charged in Minnesota
with being part of a shoplifting ring suspected of stealing around $1
million in goods across the country from the upscale athletic wear
retailer Lululemon.

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5 stalled mega mergers that could get a green light under Trump
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The climate to resurrect stalled mergers (scroll down for our list of
top 5) is more favorable in part because many predict Lina Khan, the
current chair of the Federal Trade Commission and a noted antitrust
hawk, will be out the door shortly.

Work

Virginia animal rescue pilot killed in devastating plane crash while
transporting rescue dogs
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Seuk Kim, 49, was piloting a Mooney M20J and transporting three dogs
when his plane flying from Maryland to Albany crashed about 35 miles
south of Kim's destination, according to the Green County Sheriff's
Office. Kim was found deceased on the scene as well as one of the
dogs.

Work

MrBeast Says His Videos 'Suffered a Bit' After New Project
Announcement
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MrBeast has said his recent YouTube videos "suffered a bit" while he
dedicated his time to Beast Games, a reality competition show he
created with Prime Video.

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To design better water filters, MIT engineers look to manta rays
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Filter feeders are everywhere in the animal world, from tiny
crustaceans and certain types of coral and krill, to various molluscs,
barnacles, and even massive basking sharks and baleen whales.

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Anthropic launches tool to connect AI systems directly to datasets
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Anthropic has released a new open-source tool to connect AI assistants
directly to the information they need to inform their responses or
carry out tasks. The new Model Context Protocol (MCP) provides a
universal connection to all sorts of data sources, which Anthropic
says will improve performance.

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UK Will Consider Further Relaxing Rules on London Banker Bonuses -
Bloomberg (No paywall) [[link removed]}&lead=419599&emailid=101000&nl=daily]
Regulators to consider shortening deferral periods for bonuses

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Surrealism, cafes and lots (and lots) of cats: why Japanese fiction is
booming
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Anyone who has been in a bookshop in the last few years will have
noticed that Japanese fiction is experiencing an extraordinary boom.
In 2022, figures from Nielsen BookScan showed that Japanese fiction
represented 25% of all translated fiction sales in the UK.

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How to Not Get Lost When Your GPS Fails
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Your GPS is a modern marvel of navigation--until it fails. Here's what
to do next.

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4 Todoist Templates to Streamline and Organize Your Life | The Art of
Manliness
[[link removed]}&lead=419599&emailid=101000&nl=daily?p=184889&utm_source=pocket_discover_self-improvement]
Menu random podcast Get Style Clothing Accessories Facial Hair Ties
Get Strong Fitness Health Program Review Get Social Family Fatherhood
Relationships Social Skills Get Skilled How To Manly Know-How
Outdoor/SurvivalPodcastBooks Random Find more of the Art of Manliness:

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41-year-old whose side hustle brings in $600,000 a year: This is the
'best possible way' to make money
[[link removed]}&lead=419599&emailid=101000&nl=daily]

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Bar staff to be trained to deal with incidents of drink spiking |
Politics News | Sky News
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A new pilot programme rolled out from December to spring will see
10,000 workers in the night-time economy trained to spot and prevent
cases of spiking.

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Jersey Mike's gets an $8 billion boost. What's next?
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Blackstone's deep pockets could bring Jersey Mike's to the next level

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10 Sanity-Saving Tips for Camping With Young Kids
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Taking a baby camping? Intimidating, yes--but if you equip yourself
with a bit of know-how, mitigate risk, and practice overall good
judgement, a night in the woods with a tot in tow is not only
possible, but is also actually rollicking good fun.

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New Neuroscience Reveals 4 Secrets That Will Make You Lose Weight
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Diets are a dime a dozen. What does research say it really takes to
lose weight? Here's what you need to know...

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Adipose tissue retains an epigenetic memory of obesity after weight
loss | Nature [[link removed]}&lead=419599&emailid=101000&nl=daily]
Reducing body weight to improve metabolic health and related
comorbidities is a primary goal in treating obesity1,2. However,
maintaining weight loss is a considerable challenge, especially as the
body seems to retain an obesogenic memory that defends against body
weight changes3,4. Overcoming this barrier for long-term treatment
success is difficult because the molecular mechanisms underpinning
this phenomenon remain largely unknown. Here, by using single-nucleus
RNA sequencing, we show that both human and mouse adipose tissues
retain cellular transcriptional changes after appreciable weight loss.
Furthermore, we find persistent obesity-induced alterations in the
epigenome of mouse adipocytes that negatively affect their
function and response to metabolic stimuli. Mice carrying this
obesogenic memory show accelerated rebound weight gain, and the
epigenetic memory can explain future transcriptional deregulation in
adipocytes in response to further high-fat diet feeding. In summary,
our findings indicate the existence of an obesogenic memory, largely
on the basis of stable epigenetic changes, in mouse adipocytes and
probably other cell types. These changes seem to prime cells for
pathological responses in an obesogenic environment, contributing to
the problematic ‘yo-yo’ effect often seen with dieting. Targeting
these changes in the future could improve long-term weight management
and health outcomes. Stable epigenetic changes indicate the existence
of an obesogenic memory in mouse adipocytes that primes cells for
pathological responses in an obesogenic environment and potentially
contributes to the problematic ‘yo-yo’ effect often seen with
dieting.

Work

The Lost Girls: 'Chaotic and Curious, Women With ADHD All Have Missed
Red Flags That Haunt Us'
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After multiple burnouts, in my early 30s I finally knew why life
sometimes felt harder for me. It made perfect sense, so why had no one
noticed before?

Work

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once spend our time, and how do we spend it
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One Percent
Rule","url":"[link removed]}&lead=419599&emailid=101000&nl=daily,
researching and teaching AI and Progress. Ph.D in Behavioural
Economics and Data Science. Professor of AI and Data Science. Write
@HarvardBiz Triathlete,
Climber.","identifier":"user:3646001","sameAs":["[link removed]}&lead=419599&emailid=101000&nl=daily
One Percent
Rule","url":"[link removed]}&lead=419599&emailid=101000&nl=daily","description":"Researching
and sharing information about great discoveries, critical thinking,
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this postThe One Percent RuleHow people spent their time in the
1930'sCopy linkFacebookEmailNotesMoreHow people spent their time in
the 1930'sHow did we once spend our time, and how do we spend it
now?The One Percent RuleNov 19, 202418Share this postThe One Percent
RuleHow people spent their time in the 1930'sCopy
linkFacebookEmailNotesMore74ShareIn the 1930's they spent 48 hours
working, 56 hours sleeping, 31 hours on home obligations, and 24 hours
eating or running errands. What remained, a rather precarious 9 hours
per week, was time spent in the pursuit of what could generously be
called pleasure.

Work

Lucy Manning: A sexually obscene phone call
[[link removed]}&lead=419599&emailid=101000&nl=daily]
BBC correspondent Lucy Manning describes having to fight at every
moment to keep her case on track.

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Confused About Airline Points? These Apps Help
[[link removed]}&lead=419599&emailid=101000&nl=daily]
Optimizing travel requires assistance these days.

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Six Writers on Procrastination ‹ Literary Hub
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This first appeared in Lit Hub's Craft of Writing newsletter--sign up
here.

Work

Papal Elections Aren't Always as Dramatic as 'Conclave' - But the
History Behind the Process Is
[[link removed]}&lead=419599&emailid=101000&nl=daily]
The conclave system may seem dramatic, but it was developed after
centuries of outside interference and looting.

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The GIF Is on Its Deathbed
[[link removed]}&lead=419599&emailid=101000&nl=daily]
The internet's file format has been diagnosed as "cringe," but there
are other threats to its existence.

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Dont Let Identity Thieves Use Your Social Security Number. Heres How
to Lock It
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Our expert, award-winning staff selects the products we cover and
rigorously researches and tests our top picks. If you buy through our
links, we may get a commission. Reviews ethics statement

Work

Workday stock slips on light quarterly forecast
[[link removed]}&lead=419599&emailid=101000&nl=daily]
During the quarter, Workday acquired contract lifecycle management
software startup Evisort. Workday also said artificial intelligence
agents for spotting inefficiencies, filing expense reports and
updating succession plans would become available in early access in
2025.

Work

Why AI may not help decrease radiologists' burnout
[[link removed]}&lead=419599&emailid=101000&nl=daily]
Earlier in 2024, Neuralink faced questions about the device’s
accuracy, when officials revealed that some electrodes had moved after
implantation. Currently, two people have been implanted with the
device in the United States. —Timmy Broderick

Work

Biden administration wants to rein in use of AI in Medicare Advantage,
among other fixes
[[link removed]}&lead=419599&emailid=101000&nl=daily]
More than half of people on Medicare, the program for older adults and
people with disabilities, are now enrolled in Medicare Advantage
plans, but government watchdogs and others consistently find that they
deny necessary care and collect billions in dubious payments every
year. The plan rolled out Tuesday seeks to tackle everything from the
use of artificial intelligence to misleading marketing to coverage
barriers and inaccurate provider directories. 

Work

How the Return of Salmon to the Klamath River Shows Us Whats Possible
in Wildlife Conservation - Scientific American (No paywall)
[[link removed]}&lead=419599&emailid=101000&nl=daily]
Imagine standing on a riverbank as thousands of dead salmon float
past, belly-up and rotting in the hot California air. That's the
sightand smellthat greeted people along the Klamath River in September
2002, when 35,000 fish perished there in the span of a few days. They
were victims of warm water temperatures and low river levels, both
caused by dams and diversions that altered the rivers flow.

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