Collaboration and cutting-edge science are unlocking new discoveries about our health.

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Fall 2024

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Priscilla Chan looks into a microscope while a colleague observes her work in a well-lit laboratory at the CZ Imaging Institute. ([link removed] )

During the early days of the pandemic, doctors were struggling to understand why a small fraction of kids who’d been infected with the COVID virus — and successfully fought it off — started suffering from severe inflammation and organ failure weeks later.

The condition, called MIS-C, has life-threatening consequences. The cause was a mystery until researchers made a groundbreaking discovery earlier this year. It turns out kids with MIS-C were producing antibodies and T cells that targeted not only the COVID virus, but also their own immune system.

There’s a fascinating story ([link removed] ) behind that discovery, and one of the keys to unlocking this mystery came from our San Francisco Biohub president, Joe DeRisi. He and a team of scientists had been using a tool to study antibodies called phage immunoprecipitation sequencing (PhIP-Seq). Scientists at UCSF and the San Francisco Biohub, in partnership with doctors at St. Jude Children’s Research Hospital and Boston Children’s Hospital, used PhIP-Seq to discover the root causes of MIS-C. This discovery not only unraveled the MIS-C puzzle, but has now opened new avenues for understanding autoimmune diseases more broadly.

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With care,

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CO-FOUNDER AND CO-CEO

CHAN ZUCKERBERG INITIATIVE

What I've been listening to

"Beautiful Things" by Benson Boone

How I celebrated spooky season

As a bunch of silly ballerinas ([link removed] ) — Prima Donna, Banana Ballerina, Piñata Ballerina and Fairy Ballerina.

What I’m geeked about

Daniel Baker’s 2024 Nobel Prize in Chemistry win. He and his team succeeded with the almost impossible: designing new proteins from scratch ([link removed] ) !

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