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From the Editor's Desk
Pfizer's activist troubles, gene therapy questions, RFK Jr.'s MAHA ambitions - STAT Will an activist investor campaign against Pfizer lead to big changes at the struggling pharma giant? Why are some experts questioning the regulatory standards used to approve gene therapies for Duchenne muscular dystrophy? What’s the difference between Novo Holdings and Novo Nordisk, and will it impact a $16 billion acquisition of Catalent? And what lies ahead for Robert F. Kennedy Jr. and the Make America Healthy Again movement?
We talk about all that and more on this week’s episode of “The Readout LOUD,” STAT’s biotech podcast. In our “Chatty Cathy” segment, we mull over Starboard Value’s criticisms of Pfizer and what changes, including the replacement of CEO Albert Bourla, might lie ahead. We also discuss the impact that Pfizer’s failed gene therapy in Duchenne may have on other companies developing next-generation treatments, and noodle over Novo Holdings’ controversial plan to acquire Catalent, one of the world’s largest contract drug manufacturers.
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WorkWorkDonald Trump and the F-Word - The New Yorker Donald Trump is closing crazy. Does it matter? For the historical record, let it be noted that, with less than two weeks until his third and likely final Presidential election, Trump in recent days has talked about Arnold Palmers penis size and how Joe Biden actually likes him better than Kamala Harris. He has made digressions on the history of paper clips and why teleprompters are stupid and possibly dangerous. He has suggested that Harris is drinking or on drugs, that she choked like a dog on The View, and that she is a shit Vice-President. He has complained that wind power is killing birds and stopping people from watching television. Of his own much-critiqued ramblings, he has insisted, People say its total genius.
WorkA Simple Exercise to Help You Check Your Biases - Harvard Business Review The corporate diversity, equity, and inclusion (DEI) sector is at a crossroads. Two decades of rigorous research built the business case for DEI efforts. Studies consistently show that racially diverse teams outperform their competitors in terms of profitability, and corporations with women comprising more than a quarter of their executive committees realize 10 times higher profit margin than those with no female board members. WorkHere's What to Do When It Feels Like Everyone Doubts You - Inc Recently, I invited an experienced luxury hotelier to visit the new campus we were building near Santa Fe for Modern Elder Academy, the midlife wisdom school I co-founded in 2018. Looking out at the 2,566-acre site, he remarked, Youre quite a risk-taker. Hes not wrong, but his tone was more cautionary than it was cheerleading. My entrepreneurial balloon of confidence popped.
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WorkInside Trump worlds prep for a second term - WSJ (No paywall) Anyone associated with the Heritage Foundations Project 2025, which Trump and his advisers denounced after it became a political target for Democrats, would be barred from working on the team. Transition staff used Control+F," a keyboard shortcut, to search through Project 2025s 900-plus-page policy blueprint for the names of potential hires. WorkGucci has problems. The biggest may be a safe new look - WSJ (No paywall) Kering, the French luxury group that is Guccis owner, issued its third profit warning of the year on Wednesday evening as it unveiled quarterly results and now expects 2024 operating income to be barely half last years levels. Its star brand is weak. Sales at Gucci fell 25% in the third quarter compared with the same period of 2023. The label has been shrinking for more than a year and its performance has fallen behind rival fashion brands at luxury giant LVMH.
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WorkHow To Now Get Nearly Unlimited Funding To Build Your Small Business EmpireThe golden ticket to buy a small business has always been a Small Business Administration 7(a) loan. But thanks to a recent and overlooked rule change, it just got even better, giving ambitious entrepreneurs a chance to build a diversified collection of small businesses–their own baby Berkshire Hathaways. Work WorkStudies Show Emotional Intelligence Protects You Against 4 Bad Leadership BehaviorsBut there’s more. Emotional intelligence has long been recognized as one of the most significant and impactful aspects of great leadership. When working with other people, staying emotionally open allows leaders to connect with their employees to understand better and acknowledge how they feel. In team meetings, for example, bringing emotional intelligence to the conversation creates new levels of engagement, energy, and creative thinking. WorkWorkBrain waste-clearance system shown in people for first timeThough less well-known than the body’s blood vessels, the lymphatic system is also vital to health. The network of lymphatic vessels threaded throughout the body removes dead cells and other waste from the bloodstream. It also helps transport the immune cells that fight infections. WorkThe Lion of St. Marks Square in Venice is Chinese: Isotopic Analyses Confirm ItThe discovery comes from a multidisciplinary team of experts in geology, chemistry, archaeology, and art history from the University of Padua, the Ca’ Foscari University of Venice, and the International Association for Mediterranean and Oriental Studies (Ismeo). Through advanced metallurgical analysis, the team discovered that a significant portion of the bronze used in the lion came from the lower Yangtze River basin in southeastern China, and it was likely cast during the Tang Dynasty (618-907 CE). WorkBYD EV Teardown In Japan Reveals The Secret To Its AffordabilityJapan used to be a world leader in electric and electrified vehicles in the early 2000s, but its lead has since subsided, and it lags behind most developed nations in this regard. China is the undisputed global EV leader these days, and the Central Japan Economic and Trade Bureau organized a seminar that involved the teardown of multiple EVs to see how others are already so advanced. WorkIBMs Red Hat Acquisition Will Pay For Itself By Early Next YearBig Blue has reported its financial results for the third quarter of 2024, and the thing that stands out most is not the System z16 mainframes and Power10 midrange and big iron are getting a little long in the tooth ahead of new product cycles expected to start in 2025. Revenue slumps in these two core platforms from IBM are expected at this point in the cycle, and in fact, both are holding up better than past generations of systems did this late in the cycle. WorkWorkBritain is a world leader in pet health care - The Economist AN ONCOLOGY patient lies face down, surrounded by an expert team, as they edge him into a state-of-the-art CT scanner. In the intensive-care unit a ventilated patient lies under an inflatable warming blanket, receiving one-to-one care from a specialist nurse; watching on is an anaemia sufferer wearing an unseasonal Christmas jumper. There is an emergency room but this afternoon it is empty, says Vicky Lipscomb, a soft-tissue surgeon and the hospital’s clinical director. Welcome to the Queen Mother Hospital for Animals (QMHA) in Hertfordshire. WorkWorkWorkWorkWorkWe should take awkwardness less personally, and more seriously | Aeon EssaysA man knows he should speak up about the sexist behaviour of his coworkers, but doesn’t, because they’re his friends and he doesn’t want to make it awkward. A tenured professor is bothered by her colleague’s flirtatious remarks, but says nothing, because it would be awkward to bring it up. A person runs into a recently bereaved coworker, and wonders whether to address their loss, but doesn’t know what to say, so doesn’t mention it. WorkWorkSocial Security worries hang over the incoming recipientsVoters polled by Newsweek believe that Democrats are better protectors of Social Security than Republicans, even though the issue has barely registered in the election battle between former President Donald Trump and Vice President Kamala Harris. WorkYour Vote Is SafeAs Nov. 5 approaches, former president Donald Trump has left little room for doubt about his intentions. He will almost certainly declare victory on election night, as the votes are still being counted. He may turn out to be right. But if Vice President Kamala Harris wins, Trump will reject the result as corrupt and launch a scorched-earth campaign to overturn it. WorkWorkWorkWorkApples Have Never Tasted So Delicious. Heres Why - Scientific American We are living in a golden age of apples, a time of delicious, diverse, mouth-watering abundance that we could barely have imagined at the turn of the millennium. How did we get to a time when most of us, most of the year, can eat our choice of fragrant, juicy, sweet, crisp (oh so crisp) apples? WorkWorkVoters prefer Trump, not just his policies - WSJ (No paywall) No one can say precisely whether its due to hysterical Democrats tossing unhinged insults at the Republican presidential nominee, anger over the inflation of the Biden-Harris era, exhaustion with the never-ending culture war against American tradition, or perhaps the inability of the vice president to make a case for her candidacy. But quite unexpectedly Donald Trump is becoming less controversial. WorkWorkWorkWorkWorkWorkWhat to Know About the Looming Election Certification CrisisThe post-2020 “voter integrity” movement has many leaders and includes many groups, but among the most important is Cleta Mitchell, who helped on Trump’s efforts to overturn his loss in Georgia. Mitchell, though her Election Integrity Network, has exhorted allies to get involved in elections at the state and the local level. “We are going to retake our election system,” she said on her podcast, “one county at a time all over America.” WorkWall Street has already priced in a Trump victory--just look at European stocks and the inflation marketAnd because Wall Street expects Trump to win the election, projections for the future rate of inflation have ticked up. For example, inflation compensation, which is the premium investors are willing to pay to protect the real value of their returns from inflation, rose since September, according to Bank of America. Part of the increase was due to positive economic data. Another part had to do with Trump’s political fortunes. WorkS&P 500 Poised for Weekly Drop After Yield Spike: Markets Wrap(Bloomberg) -- S&P 500 futures were little changed, with the index heading for its first weekly drop in seven as rising borrowing costs put a chill on investor sentiment.Most Read from BloombergRobotaxis Are No Friend of Public TransportationBooming Cambridge Exposes England’s Widening Wealth GapOman Sees an Urban Future Distinct From Dubai and Abu DhabiArgentina Drug Trafficking Hotspot Sees Murders PlungeClimate Change Is Killing Buildings in Slow MotionThe US stocks benchmark is set for an al WorkWorkHow Trump is a fascist became Kamalas closing argumentThe US presidential campaign is in its final weeks and were dedicated to helping you understand the stakes. In this election cycle, its more important than ever to provide context beyond the headlines. But in-depth reporting is costly, so to continue this vital work, we have an ambitious goal to add 5,000 new members. WorkThe 'Greenest Governor' Fights to Save a Landmark Climate LawThe vote on the measure, Initiative 2117, is being watched across the country and around the world as government leaders struggle with how to put in place plans with enough potency to drastically alter carbon emissions — the primary cause of global warming — while answering to voters concerned about the costs. WorkHarris and Trump Deadlocked to the End, Final Times/Siena National Poll FindsWhile this latest Times/Siena College poll offers a glimpse into national sentiment, the presidential election will be decided in the seven battleground states where Ms. Harris and Mr. Trump have devoted the overwhelming amount of their time and resources. Most polls in those states — Arizona, Georgia, Michigan, Nevada, North Carolina, Pennsylvania, Wisconsin — suggest the contest is equally close. |
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