First full day of AIDS 2024
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[link removed] July 24, 2024
** First full day of AIDS 2024
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Dear Advocate,
Lenacapavir for PrEP ([link removed]) has taken center stage at the 25th International AIDS Conference ([link removed]) , #AIDS2024, which opened Monday with many highlighting its potential for long-acting PrEP for HIV prevention. Some advocates took to the halls in protest calling on LEN’s maker to price the product low. Leaders across HIV voiced the need for urgency in galvanizing support for the introduction of lenacapavir. “It is gobsmackingly exciting to see zero in a clinical trial” AVAC’s Mitchell Warren told Forbes ([link removed]) . The potential to bend the curve of the epidemic depends on speeding access to prevention options like LEN, that show high efficacy.
At the same time, it’s imperative to remember that neither lenacapavir, nor any other single product, now or in the future, will ever be a ‘miracle drug’, and LEN must not be equated with a vaccine, as seen in some conference media reports.
Ongoing investment in the pipeline for HIV prevention must be founded on the principle of choice, offering a range of products to meet diverse needs among people facing the risk of HIV. We hope that vaccines will one day be among those choices, as will long and short-acting products, and topical and systemic products. Clear communication that allows product users to understand how products are different supports widespread adoption of HIV prevention and moves the world toward finally ending the epidemic.
See AVAC’s statement ([link removed]) calling for early planning to accelerate LEN’s regulatory review and for ambitious introduction plans, and the joint civil society call to action ([link removed]) with specific priorities about what needs to happen next. Our primer, the Lens on LEN ([link removed]) , also offers advocates a guide in explaining the findings from the Purpose 1 trial and next steps for advocacy.
As Albert Liu from UCSF’s Center for AIDS Research told delegates in the symposium on breakthrough and insights in long-acting technologies, "It's never just the 'product.' New options can't solve everything." Atul Gawande of USAID ([link removed]) reiterated a similar message at the satellite focused on women’s prevention ([link removed]) , “The critical message to understand is that there isn’t going to be a magic bullet for prevention. What we have to understand is that there are also considerations that affect the likelihood that women will have what they want and what they’re likely to use.”
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People First
The conference theme, "Put People First," is the main message we all must hear. Lillian Mworeko of the International Community of Women living with HIV/AIDS East Africa (ICWEA) captured the essence of the meeting: “I am not just a recipient of care. I need a seat at the table to meaningfully engage and tell people what I need and how I need it.”
Monday’s opening session ([link removed]) underscored the vital role of community engagement and the necessity for inclusive policies that address disparities affecting marginalized populations. Jay Mulucha of Fem Alliance, Uganda, the first trans man to speak at the International AIDS Conference, delivered a compelling message to the 12,000+ delegates attending both in person and online: “As a trans man living in Uganda, I am asking you to stop leaving us behind. Nothing about us, without us.”
New UNAIDS Report
UNAIDS released a report, The Urgency of Now, AIDS at a Crossroads ([link removed]) calling out funding disparities and the need to dismantle the discrimination and stigma that are pushing the most marginalized people away from health care. The report warned of the peril in delayed funding decisions; investment needs to happen urgently for long-acting treatment and prevention options to reach all low- and middle-income countries and meet 2025 targets.
Money, Money, Money
Making the most of investment in HIV prevention fundamentally depends on political will, but the field needs the right data, too. Monday’s satellite session, Money, money, money: Building towards a sustainable end state for HIV prevention ([link removed]) , called for better data that goes beyond PrEP initiation numbers. “[PrEP initiations] alone do not tell us how much product is needed or how long people stay on PrEP. We are not collecting the right data,” said Katherine Kripke of Avenir Health ([link removed]) . AVAC’s Mitchell Warren described the vicious cycle of small pilot projects generating limited data on PrEP use, resulting in unpredictable demand and cautious investment. “We have lots of small examples, and then we don’t scale it up because governments don’t know what it will cost. And still the world has 1.3 million new infections. We have to break the cycle.”
The Future of Women’s Prevention
At the session organized by CASPR (Coalition to Accelerate & Support Prevention Research ([link removed]) ) and MATRIX (Microbicide R&D to Advance HIV Prevention Technologies through Responsive Innovation and Excellence ([link removed]) ), New ways for the next wave: Innovative R&D for the future of women's prevention ([link removed]) , MATRIX laid out their innovative approach that involves very early engagement of all stakeholders in the research, development and delivery of new products for HIV prevention. The session emphasized the equitable inclusion of women in all phases and in every aspect of R&D—as researchers, potential users, and advocates.
Sharon Hillier of Magee-Women’s Research Institute ([link removed]) noted, “What we've learned in our research is that women care about efficacy, but it's just one element of what they consider when they decide on prevention. They're quite interested in safety, ease of use, discretion, price, availability, and accessibility.”
Stay tuned for more highlights from AIDS 2024 and visit our curated conference webpage ([link removed]) , which includes new resources and summaries of the preconference sessions.
Best,
AVAC
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AVAC Global Advocacy for HIV Prevention
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