Post : Why Does My Child Have a Knot in Their Leg After Their Vaccine?
URL : [link removed]
Posted : May 2, 2024 at 1:01 am
Author : Vincent Iannelli, MD
Tags : allergy, aluminum, granuloma, itching, knot, lump, nodule, vaccination granuloma, vaccination nodule
Categories : Vaccine Side Effects

Does your child have a lump or knot in their leg after getting a vaccine?

Is that a normal reaction?

Why Does My Child Have a Knot in Their Leg After Their Vaccine?

Developing a lump or knot in their leg after getting a vaccine is a common and very normal vaccine reaction.

[link removed] Developing a temporary knot or hard lump is common after many vaccines.

It is well known that most vaccines will cause local reactions, with pain, tenderness, swelling, and tenderness where it was injected. Local reactions that are typically mild and go away with no or minimal interventions.

And then, in addition to these local reactions, some kids develop lumps or knots at the injection site.

These knots are usually painless and go away in a few days or weeks.

If the knot is bothersome, you can apply a warm compress to the injection site a few times a day.

Persistent Vaccination Nodules

What about a lump or knot that doesn't go away in a few days or weeks?

> "Granulomas are a local formation of specific cells including macrophages and lymphocytes, revealing a chronic inflammatory reaction against an inciting agent. The etiology of vaccination granulomas has been described as an inflammatory response incited by the injection of a vaccine, particularly those which are aluminum adsorbed."
>
> The Evaluation of Palpable Thigh Nodularity in Vaccination-age Children – Differentiating Vaccination Granulomas from Other Causes

In this case, the knot might have developed into a granuloma.

Why do some kids develop these knots?

> "Rarely, delayed-type hypersensitivity to a vaccineconstituent can cause an injection-site nodule, but this is not acontraindication to subsequent vaccination."
>
> Adverse reactions to vaccines practice parameter 2012 update

It could be a delayed-type hypersensitivity to a vaccine constituent (usually aluminum ( [link removed] ) or neomycin ( [link removed] ) ), especially if the shot wasn't injected deep enough into the muscle and some leaked into the subcutaneous space under the skin.

> "Vaccine-induced itching granulomas caused by an aluminium-adsorbed acellular pertussis toxoid vaccine seem to disappear over time. Future vaccinations with aluminium-adsorbed vaccines can be performed with little risk for new itching nodules later in life."
>
> Long-term clinical course and prognosis of vaccine-related persistent itching nodules (1997–2019): An observational study

These knots, granulomas, or nodules eventually go away, are not usually a sign of any kind of systemic allergy or injury, and are not a reason to skip or delay your child's vaccines.

More on Vaccine Side Effects

* Why Did My Child Get a Fever After Their MMR Vaccine? ( [link removed] )

* DTaP Vaccine Reactions – Is This Normal? ( [link removed] )

( [link removed] ) How Often Do Severe Events Occur After Vaccines? ( [link removed] )

* How Long Do Side Effects of Immunizations Last? ( [link removed] )

* Is This a Horrible Vaccine Reaction? ( [link removed] )

* Injection site nodules ( [link removed] )

* Treatment of local injection reactions ( [link removed] )

* Adverse reactions to vaccines practice parameter 2012 update ( [link removed] )

* The Evaluation of Palpable Thigh Nodularity in Vaccination-age Children – Differentiating Vaccination Granulomas from Other Causes ( [link removed] )

* Long-term clinical course and prognosis of vaccine-related persistent itching nodules (1997–2019): An observational study ( [link removed] )

* Sixty-four children with persistent itching nodules and contact allergy to aluminium after vaccination with aluminium-adsorbed vaccines-prognosis and outcome after booster vaccination ( [link removed] )

* Immunization Reactions ( [link removed] )

* After your child is immunised ( [link removed] )

* What is normal after vaccination? ( [link removed] )

* Aluminum-based vaccine adjuvants: much ado about nothing ( [link removed] )

* Posts Raise Unfounded Concerns About Aluminum in Vaccines ( [link removed] )

* The level of aluminum in childhood vaccines is safe, even for babies ( [link removed] )

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