From the Editor's Desk

Alzheimers may be caused by a build-up of fat in brain cells - New Scientist (No paywall)

But this debate ignores the fact that fat droplets can also be seen in the brains of people who have died from the disease, says Haney. These were first described by Alois Alzheimer, a German doctor who gave his name to the condition in the early 20th century, when he noted amyloid plaques, tau tangles and fat droplets present in the brains of people who had Alzheimer’s. But for decades the fat was mostly overlooked.

To shed more light, Haney and his colleagues carried out a series of experiments while he was working at Stanford University in California. First, the team used a relatively recent technique called single-cell RNA sequencing to identify which proteins were being made in individual cells. They applied this to tissue samples from people who had died from Alzheimer’s disease, who had either two copies of the APOE4 variant or two copies of APOE3.

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