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How the new generation of weight-loss drugs work - The Economist   

This article is part of our Summer reads series. Visit the full collection for book lists, guest essays and more seasonal distractions.

WEIGHT-LOSS DRUGS are everywhere. In newspapers, on social media or by the water cooler, the gossip about injections that can help to melt away 10-20% of one’s body weight is hard to avoid. The real news is getting buried. These drugs offer a powerful new option to treat obesity, which is now widely accepted by doctors as a chronic disease. Being seriously overweight raises a person’s risk of suffering from diabetes, heart disease, strokes and 13 cancers. But there is evidence that, for most people, dieting is not an effective way to lose and keep off large amounts of weight: the body fights attempts to shift more than a little. How might new drugs help?

The history of weight-loss medication is a sorry tale. In 1934 as many as 100,000 Americans were using dinitrophenol to shed excess pounds. It is toxic, causing cataracts and, occasionally, deaths. By one estimate 25,000 people were blinded by the drug; it was banned as a drug for human use in 1938 but deaths continue to this day as people are still enticed to buy it online. Next amphetamines became popular—until the risk of addiction and other side-effects became apparent. Ephedra, a herbal medication which in 1977 was taken by an estimated 70,000 people, was also banned in America after it led to deaths. Two other weight-loss drugs, rimonabant and sibutramine, were withdrawn from sale because of safety concerns.

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