Pancreatic Cancer Vaccine Shows Promise in Small Initial Trial | Sam Bankman-Fried Considered Paying Trump $5 Billion Not To Run For President, New Book Says—Why The Deal May Have Been Legal | What PwC Learned from Its Policy of Flexible Work for Everyone | Michael Jordan Is Now Worth $3 Billion And Joins The Forbes 400

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Pancreatic Cancer Vaccine Shows Promise in Small Initial Trial - Scientific American

An mRNA vaccine prevented tumor recurrence after surgery in eight of 16 patients, but the therapy still needs to be validated in larger trials

Pancreatic cancer is one of the deadliest forms of cancer, with very few effective treatments. But messenger RNA (mRNA) vaccines—famous for their ability to prevent COVID—are starting to show some promise against the lethal cancer. In a recent early-stage trial, half of pancreatic cancer patients who received a personalized mRNA cancer vaccine after surgery did not have a recurrence of the tumor a year and a half later. The trial, which was described in a study published on Wednesday in Nature, was small—with just 16 patients—and it will need to be replicated in larger studies.

“I am very supportive of the findings,” says Drew Weissman, director of vaccine research and director of the Institute for RNA Innovation at the University of Pennsylvania, who is a pioneer of mRNA vaccines but was not involved in the new paper. He adds that “it is not a definitive proof-for-use study. Larger studies are needed to determine effectiveness.”

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Sam Bankman-Fried Considered Paying Trump $5 Billion Not To Run For President, New Book Says—Why The Deal May Have Been Legal - Forbes

Disgraced FTX founder Sam Bankman-Fried reportedly considered paying former President Donald Trump $5 billion not to run for office, according to a new bookâand despite Trump's previous declaration that such a move could be illegal, experts suggest that paying a candidate to drop out of a race could actually fall within the confines of the law.

Samuel Bankman-Fried leaves Manhattan Federal Court on Thursday, March 30, 2023, in Manhattan, New ... [+] York. (Barry Williams/New York Daily News/Tribune News Service via Getty Images)

Bankman-Fried received the offer after he "somehow created a back channel to the Trump operation," Lewis wrote, adding that Bankman-Fried was "exploring the legality" of the hypothetical scenario.

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What PwC Learned from Its Policy of Flexible Work for Everyone - Harvard Business Review

When it comes to flexible workplace policies, the key is to actually be “flexible.” It seems counterintuitive, but having rules in place can work against you. That’s why PricewaterhouseCoopers instilled a policy they loosely call “everyday flexibility.” It isn’t something the company mandates that all teams adopt; it’s a mentality and a way of life that is meant to be individualized for each person. The key is understanding that it’s impossible to have a one-size-fits-all approach to flexibility. Every employee, at any age, benefits from and is looking for its availability. Flexibility for a caregiver might mean being able to leave work early to take an elderly parent to a doctor’s appointment. For a parent, it might mean taking a midday run, so evenings can be spent with their children. And for others, it could simply be taking an hour in the afternoon to go to a yoga class and recharge. So, make sure that internal communications about flexibility speak to all employees. Remember, if you trusted an individual enough to hire them, you also should trust them enough to get work done when and where they prefer.

Every Tuesday at 7:30 a.m. Pacific Time, I join a video conference call with leadership colleagues from across the country. I’m on the West Coast, so these meetings are always early for me. When I started joining them more than 10 years ago, I was up early to ensure that I looked polished and ready to conquer the day before I got on the video conference. These days, I find myself forgoing dressing up or putting on makeup before dialing in. I no longer think twice about being on video from the comfort of my living room and in my morning sweatshirt. And, as I say good morning to my colleagues, it’s apparent that I’m not the only one.

It hasn’t always been this way. Our company has come a long way over the past decade by truly instilling a culture of flexibility across the firm. We now have the ability to work in a way that fits our personal lives and, if that means taking an early morning video call at home in our sweatpants, then so be it.

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Michael Jordan Is Now Worth $3 Billion And Joins The Forbes 400 - Forbes

Since Michael Jordan stepped onto an NBA court for the first time in 1984, earning an outsized payday has been a layup. Across his 15 NBA seasons, he hauled in $94 million and was the league’s highest-paid player in 1997 and 1998. But it was off the court where Jordan put serious air between himself and every other athlete on the planet, earning an estimated $2.4 billion (pre-tax) over his career with brands such as McDonald’s, Gatorade, Hanes and, of course, Nike, where his most recent yearly royalty check was for some $260 million.

Jordan had his biggest score in August, though, when he sold his majority stake in the Charlotte Hornets at an eye-watering $3 billion valuation. Even if he had sold at Forbes’ most recent valuation, an estimated $1.7 billion in 2022, it would have been a coup for the 60-year-old Hall of Famer. Instead, the 27th most valuable franchise in the NBA traded hands for the second-highest sale price in league history and nearly 17 times its value when Jordan became principal owner in 2010.

That places him in rare air. With an estimated net worth of $3 billion, Jordan has arrived on The Forbes 400, marking the first time a professional athlete has ranked among America’s wealthiest individuals.

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