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Bowel cancer is rising among young people - The Economist   

When Dame Deborah James, a British teacher-turned-journalist, was diagnosed with bowel cancer she was just 35 years old. She died less than six years later in 2022, after documenting her life with the disease and raising more than £11m ($13.7m) for bowel-cancer research and awareness. Her death at that young age shocked many. But data suggest that cases like hers are becoming more common (see chart 1).

Bowel cancer, also known as colorectal cancer, is the second-most lethal cancer worldwide after lung cancer. But cases in many high-income countries have steadily fallen across older age groups over the past two decades. In America, rates among people aged over 75 have more than halved, from 386 to 173 per 100,000 people; the pattern is similar for people between the ages of 65 and 74. But there is a peculiar trend emerging among younger people. Rates for those aged between 15 and 39 almost doubled between 2000 and 2020, from three to 5.4 per 100,000. Because young people are not screened, the real number of under-50s with bowel cancer is probably much higher than the data suggest. In 2020 the pandemic also led to fewer people than normal being diagnosed, meaning the increase could be even greater.

The reason for this trend among the young is unclear, though it fits with a general increase in worldwide cancer cases in people aged under 50. Bowel cancer has previously been associated with problems such as an unhealthy lifestyle and poor diet. Studies also indicate that bowel cancer is linked to specific bacterial communities in the gut. One meta-analysis suggested that young people with bowel cancer have particular microbiome profiles. Because tumours can take decades to grow, these factors could stretch back into childhood.

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Richard Brody’s New York Film Festival Highlights - The New Yorker   

It was a scandal when, in 1969, the New York Film Festival showed Paul Mazursky's extramarital romp "Bob & Carol & Ted & Alice" in its Lincoln Center sanctuary, but these days few doubt that art can issue from Hollywood. Several industry notables will grace this year's edition of the festival, which kicks off tonight and runs through Oct. 15, including Todd Haynes, whose drama "May December"—featuring Natalie Portman as an actor preparing to portray a subject of a long-ago scandal (Julianne Moore)—is the opening-night offering. But N.Y.F.F. is largely a celebration of movies that likely won't be on hundreds of multiplex screens and yet are no less worthy of attention, such as the idiosyncratic and intimate comedy "The Feeling That the Time for Doing Something Has Passed"—written and directed by Joanna Arnow, who also stars as a thirtysomething Brooklyn woman whose quest for a romantic relationship conflicts with her desire to be sexually dominated—and "In Water," one of a pair of films by the veteran South Korean director Hong Sangsoo, about a young independent filmmaker's reckless effort to shoot an improvised drama. Many of Hong's images are intentionally out of focus, to surprising emotional effect, emphasizing the force of the film's confessional and confrontational dialogue.

But pride of place regarding long dialogue scenes of wondrous intensity goes to the Japanese drama "Evil Does Not Exist," directed by Ryûsuke Hamaguchi (whose 2021 film "Drive My Car" was nominated for four Oscars and won one, for Best International Feature Film). It's the story of a rural village of artisans and farmers whose way of life is threatened by a businessman's plan to open a glamping lodge there. Discussions among the villagers and the developers—as at a contentious public hearing—display a depth of practical knowledge and introduce a twisty succession of subjects that seem borrowed from the institution-probing documentaries of Frederick Wiseman. Hamaguchi flaunts his quasi-documentarian sensibility in wordless scenes, too, including an extraordinary long take of a woodcutter at work which is among the cinematic thrills of the year.

Few rappers can claim to be as skilled as Little Simz, a British Nigerian artist who has steadily grown from phenom to bellwether. Her early albums were about transitioning into adulthood, finding her way through the uncertainty of her early twenties to realize her purpose. Even then, it was clear that her path was fated—her lyricism is fluid yet rugged, casual even at its most technical, foreshadowing a future as one of rap's most distinguished soul-searchers. In the years since she established herself as a mainstay, she has performed with brio and bravado: "Name one time where I didn't deliver," she raps on "Gorilla," already knowing the answer. Not only has Simz always come through; she just keeps getting better.—Sheldon Pearce (Brooklyn Steel; Oct. 12.)

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