Alzheimer's Association International Conference® 2023 is a wrap — what comes next depends on you.

Dear Friend, I'm so grateful to the educators, dementia scientists and advocates who traveled from around the world to the Alzheimer's Association International Conference® 2023 (AAIC®). They know there's no better place to learn about all the latest developments in Alzheimer's science, network, share and collaborate. I'm also thankful to you. The kind of progress that was made at AAIC this week doesn't happen without the generous support of new partners in the fight against Alzheimer's — like you. Friend, the generosity and commitment of friends like you helps make AAIC possible. This past week at AAIC was packed with: Advances in Treatments, and Clinical Trial Results: New, more complete data were reported at AAIC 2023 by Eli Lilly from the TRAILBLAZER-ALZ 2 Phase 3 clinical trial of donanemab in early symptomatic Alzheimer's disease. With this fuller picture of the donanemab Phase 3 results we see additional convincing scientific evidence that thoroughly removing beta amyloid from the brain is associated with significant slowing of disease progression in people living with early Alzheimer's. The results of this trial also further illustrate that initiating treatment as early as possible in the course of the disease enables the possibility of a bigger beneficial effect, but also that there is potential for slowing of disease progression even when treatment is started later. The progress we've seen in this class of treatments, as well as the diversification of potential new therapies over the past few years, provides hope to those impacted by this devastating disease. Blood Tests: The Next Frontier in Alzheimer's Diagnosis: Researchers from University of Gothenburg, Sweden, reported results from a simple, finger prick blood test that shows promise in the ability to detect markers of Alzheimer's using a single drop of blood dried on spot cards and shipped overnight between two countries, without temperature control or cooling. If validated through additional research, this test could offer a quick, noninvasive and cost-effective option that is simple enough to be performed independently, or by caregivers. It may be particularly valuable for use in rural districts or other lower resourced areas. Volunteering Later in Life May Promote a Healthy Brain: Reported for the first time at AAIC 2023, researchers from University of California Davis examined volunteering habits among an ethnic and racially diverse population of older adults and found that volunteering was associated with better baseline scores on tests of memory, thinking and planning. The researchers stated volunteering may be important for better cognition in late life and could serve as a simple intervention in older adults to protect against Alzheimer's and other dementias. What comes next — more clinical trials, new approaches to care and support, and increased advocacy to ensure people living with the early stages of Alzheimer's have access to new Food and Drug Administration-approved treatments — won't happen without your support. We must seize the momentum and do all we can to accelerate research progress while being there for those living with Alzheimer's with the care and support that is so needed. As these researchers return to their labs and offices, their work will continue, and so will ours, until we achieve our vision of a world without Alzheimer's and all other dementia. Will you help us kick off this exciting new era in the fight to end Alzheimer's with your first gift now? I truly believe the sharing and collaborating that took place this week will lead to more breakthrough research discoveries. Thank you for supporting our mission to lead the way to end Alzheimer's and all other dementia — by accelerating global research, driving risk reduction and early detection, and maximizing quality care and support. Gratefully, Donna McCullough Chief Mission and Field Operations Officer P.S. While another successful and energizing AAIC has ended, our work toward a future free from Alzheimer's and helping improve the lives of those affected by dementia is ongoing. Please support all our vital work with your first gift now.

Your donation will strengthen our efforts to advance Alzheimer's care, support and research. From face-to-face support to online education programs and promising global research initiatives, your gift makes a difference in the lives of all those affected by Alzheimer's and other dementias in your community and across the world. Thank you for your continued support. Alzheimer's Association Home Office, 225 N. Michigan Ave., Fl. 17, Chicago, IL 60601 © 2023 Alzheimer's Association. All rights reserved. 800.272.3900 | alz.org® | Donate Please add [email protected] to your address book to ensure you receive all future emails.   Having trouble reading this email? View it in your browser   View your email preferences or unsubscribe.

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