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IZ Express #1,695: Mpox outbreak potential, mRNA vaccine durability, and more
| From | Immunize.org <[email protected]> |
| Subject | IZ Express #1,695: Mpox outbreak potential, mRNA vaccine durability, and more |
| Date | May 31, 2023 10:45 AM |
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Issue 1,695: May 31, 2023
Top Stories
* Immunize.org updates its "Checklist of Current Versions of U.S. COVID-19 Vaccination Guidance and Clinic Support Tools” to include new bivalent mRNA vaccine standing orders for children and adults from CDC. New version dated May 29.
* "Potential for Recurrent Mpox Outbreaks in Gay, Bisexual, and Other Men Who Have Sex with Men—United States, 2023" published in MMWR
* "Urban and Rural Mpox Incidence among Persons Aged 15–64 Years—United States, May 10–December 31, 2022" published in MMWR
* "Estimates of Bivalent mRNA Vaccine Durability in Preventing COVID-19–Associated Hospitalization and Critical Illness among Adults with and without Immunocompromising Conditions—VISION Network, September 2022–April 2023" published in MMWR
* Pew Research Center finds that Americans’ mostly positive views on childhood vaccines remain
* Calling students in grades 6 through 12: 2023 Dr. Maurice R. Hilleman Essay Contest, sponsored by CHOP’s Vaccine Education Center, open for submissions
* Immunize.org’s Hepatitis B Birth Dose Honor Roll recognizes 578 institutions, including two new honorees
* Spotlight: Immunize.org resources focused on vaccine-preventable diseases, one disease at a time
* Vaccines in the news
Immunize.org Pages and Handouts
* Immunize.org updates the standing orders template for administering inactivated poliovirus vaccine to infants and children
* Immunize.org posts corrected Simplified Chinese translation of “After the Shots . . . What to Do If Your Child Has Discomfort”
* Immunize.org refreshes several popular handouts; make sure you use the latest versions
Featured Resources
* CHOP releases new video that addresses treating fevers; check out the “Healthy at Home with Dr. Handy” playlist
Notable Publications
* "COVID-19 Booster Vaccination in Early Pregnancy and Surveillance for Spontaneous Abortion" published in JAMA Network Open
* "Evaluation of Waning of SARS-CoV-2 Vaccine–Induced Immunity: A Systematic Review and Meta-Analysis" published in JAMA Network Open
* "Estimated U.S. Pediatric Hospitalizations and School Absenteeism Associated with Accelerated COVID-19 Bivalent Booster Vaccination" published in JAMA Network Open
Upcoming Events
* Virtual: Immunization Coalition of Los Angeles hosts Summer Vaccine Film Forum on June 20
* Virtual: Watch June 21–23 ACIP meeting. Topics include RSV, polio, influenza, pneumococcal, dengue, chikungunya, mpox, meningococcal, and COVID-19 vaccines.
------------------------------------------------------------
Top Stories
------------------------------------------------------------
Immunize.org updates its "Checklist of Current Versions of U.S. COVID-19 Vaccination Guidance and Clinic Support Tools” to include new bivalent mRNA vaccine standing orders for children and adults from CDC. New version dated May 29.
Immunize.org reviews and updates the Checklist of Current Versions of U.S. COVID-19 Vaccination Guidance and Clinic Support Tools ([link removed]) at least monthly, prominently indicating when it was last revised at the top of the page. The checklist was updated a third time in May because CDC released widely anticipated new standing orders templates reflecting the most current recommendations for use of bivalent mRNA vaccines in children and adults. Our checklist also reflects CDC’s new interim COVID-19 vaccination schedule for all ages.
All COVID-19 vaccination providers should review the checklist regularly and download the latest CDC schedule and standing order documents. The checklist is posted on Immunize.org's Vaccines: COVID-19 ([link removed]) main page to help practices stay up to date.
Related Links
* Immunize.org: Checklist of Current Versions of U.S. COVID-19 Vaccination Guidance and Clinic Support Tools ([link removed]) (PDF)
* Immunize.org: Vaccines: COVID-19 ([link removed]) main page
* Immunize.org: Ask the Experts: COVID-19 ([link removed]) web page
* CDC: Interim Clinical Considerations ([link removed]) main page summarizing use of COVID-19 vaccines in the United States
------------------------------------------------------------
"Potential for Recurrent Mpox Outbreaks in Gay, Bisexual, and Other Men Who Have Sex with Men—United States, 2023" published in MMWR
CDC published Potential for Recurrent Mpox Outbreaks in Gay, Bisexual, and Other Men Who Have Sex with Men—United States, 2023 ([link removed]) in the May 26 issue of MMWR ([link removed]). A portion of the summary appears below.
Monkeypox (mpox) has disproportionately affected gay, bisexual, and other men who have sex with men (MSM); the percentage of MSM with immunity due to vaccination or infection varies among jurisdictions. . . .
Mathematical modeling suggests that the risk for future outbreaks depends linearly on the level of immunity in the population at risk; cumulative incidence, on the other hand, has multiple thresholds [based on proportion of immune individuals]. More than 592,000 MSM live in jurisdictions with risk for mpox recurrences capable of sustained transmission if a cluster of infectious cases were reintroduced. . . .
Increasing vaccination coverage among MSM at risk and in jurisdictions with low immunity has the potential to reduce the risk for and potential size of future mpox outbreaks.
Access the MMWR article in HTML ([link removed]) or PDF ([link removed]) .
Related Link
* MMWR's main page ([link removed]) provides access to MMWR Weekly and its companion publications
------------------------------------------------------------
"Urban and Rural Mpox Incidence among Persons Aged 15–64 Years—United States, May 10–December 31, 2022" published in MMWR
CDC published Urban and Rural Mpox Incidence among Persons Aged 15–64 Years—United States, May 10–December 31, 2022 ([link removed]) in the May 26 issue of MMWR ([link removed]). A portion of the summary appears below.
Information on urbanicity of mpox cases during the 2022 outbreak is limited. . . .
During May–December 2022, U.S. mpox incidence was 13.5 per 100,000 persons peaking in August. Among cisgender men and cisgender women, incidence in rural areas was 4% and 11% of incidence in large central urban areas, respectively. Incidence among Black or African American and Hispanic or Latino persons was higher than among White persons. . . .
National mpox surveillance should be continued to ensure persons at risk for mpox get tested and treated. Prevention efforts should be focused on MSM in urban areas.
Access the MMWR article in HTML ([link removed]) or PDF ([link removed]) .
Related Link
* MMWR's main page ([link removed]) provides access to MMWR Weekly and its companion publications
------------------------------------------------------------
"Estimates of Bivalent mRNA Vaccine Durability in Preventing COVID-19–Associated Hospitalization and Critical Illness among Adults with and without Immunocompromising Conditions—VISION Network, September 2022–April 2023" published in MMWR
CDC published Estimates of Bivalent mRNA Vaccine Durability in Preventing COVID-19–Associated Hospitalization and Critical Illness among Adults with and without Immunocompromising Conditions—VISION Network, September 2022–April 2023 ([link removed]) in the May 26 issue of MMWR ([link removed]). A portion of the summary appears below.
Bivalent mRNA COVID-19 vaccines help provide protection against medically attended COVID-19–associated illness. However, the durability of this protection is uncertain. . . .
Among adults aged ≥18 years without immunocompromising conditions, bivalent booster vaccine effectiveness (VE) against COVID-19–associated hospitalization declined from 62% at 7–59 days postvaccination to 24% at 120–179 days compared with VE among unvaccinated adults. Among immunocompromised adults, lower bivalent booster VE was observed. However, bivalent booster VE was sustained against critical COVID-19–associated outcomes, including intensive care unit admission or death. . . .
Adults should stay up to date with recommended COVID-19 vaccines. Optional additional bivalent vaccine doses are available for older adults and persons with immunocompromising conditions.
Access the MMWR article in HTML ([link removed]) or PDF ([link removed]) .
Related Link
* MMWR's main page ([link removed]) provides access to MMWR Weekly and its companion publications
------------------------------------------------------------
Pew Research Center finds that Americans’ mostly positive views on childhood vaccines remain
According to a survey conducted by the Pew Research Center ([link removed]) in March 2023, Americans remain steadfast in their belief in the overall value of childhood vaccines. However, there are signs of some concern, particularly among parents of young children and mothers. While the last 4 years demonstrated no change in the large majority who say the benefits of childhood vaccination against measles, mumps, and rubella (MMR) outweigh the risks, there is a sizable gap between higher public confidence in childhood vaccines and lower confidence in COVID-19 vaccines.
Other key findings:
* Fewer than half of Americans rate their perception of COVID-19 vaccines’ health benefits as high, but the majority perceive the risk of side effects as at least medium
* Americans’ positive perception of MMR vaccine remains largely steady in the wake of debate over COVID-19 vaccines
* Politically partisan differences widened over the requirement for MMR vaccine in K-12 schools
* Parents whose children are less than age 18 years perceive slightly higher risks from MMR vaccines than other adults
* The majority of Americans perceive a positive societal impact from childhood vaccines, though about four-in-ten wonder if vaccines are all necessary
* Doctors are at least somewhat trusted as sources of information about the health effects of MMR vaccine
* Interviews with those concerned about MMR vaccine reveal desires to rely on multiple sources of information, ones they believe to have trustworthy motives
Read the full report: Americans’ Largely Positive Views of Childhood Vaccines Hold Steady ([link removed]) .
------------------------------------------------------------
Calling students in grades 6 through 12: 2023 Dr. Maurice R. Hilleman Essay Contest, sponsored by CHOP’s Vaccine Education Center, open for submissions
The Vaccine Makers Project ([link removed]), the classroom-based program of the Vaccine Education Center (VEC) at Children’s Hospital of Philadelphia, invites submissions for the 2023 Maurice R. Hilleman Essay Contest. Students in grades 6 through 12 in the United States and Canada are encouraged to learn about Dr. Hilleman’s life and accomplishments and submit a 500- to 600-word essay by June 9, 2023. This year's writing prompt is "Preparedness is an important component of science as demonstrated by Maurice Hilleman when he identified the 1957 influenza pandemic. How is preparedness critical in science today?"
Details and the entry form are available at HillemanFilm.com/contest ([link removed]). This year there will be six winners—three each from the United States and Canada. The winners will each receive $500, a certificate, and recognition at a virtual award event this fall. Please share this information with eligible students or with teachers who may be interested in sharing with their students.
Related Links
* The Vaccine Makers Project ([link removed]) website
* VEC: Hilleman Film ([link removed]) website
------------------------------------------------------------
Immunize.org’s Hepatitis B Birth Dose Honor Roll recognizes 578 institutions, including two new honorees
Immunize.org is pleased to welcome two new institutions into its Hepatitis B Birth Dose Honor Roll ([link removed]), for a total of 578 honorees. The birthing institutions are listed below with their reported hepatitis B birth dose coverage rates in parentheses.
* Reynolds Memorial Hospital, Glen Dale, WV (95%)
* UPMC Chautauqua, Jamestown, NY (90%)
Several institutions are being recognized for qualifying for an additional year:
* St. Joseph’s Hospital North, Lutz, FL (92%) (2 years)
* Union Hospital, Terre Haute, IN (100%) (5 years)
* Platte Valley Medical Center, Brighton, CO (90%) (7 years)
* Arkansas Valley Regional Medical Center, La Junta, CO (91%) (9 years)
* Perry County Memorial Hospital, Tell City, IN (91%) (11 years)
The Honor Roll includes 578 birthing institutions from 45 states, the District of Columbia, Puerto Rico, Guam, Saipan, and our U.S. military base in England.
[link removed]
The Honor Roll is a key part of Immunize.org’s initiative urging the nation’s hospitals to Give Birth to the End of Hep B ([link removed]). Hospitals and birthing centers are recognized for attaining high coverage for hepatitis B vaccine at birth and meeting additional criteria. To learn whether your organization qualifies and to access the application form, please see Hepatitis B Birth Dose Honor Roll online ([link removed]).
Honorees are awarded an 8.5" x 11" color certificate suitable for printing and framing and their acceptance is announced through Immunize.org’s social media channels and to IZ Express’s 54,000+ readers.
Please visit the Hepatitis B Birth Dose Honor Roll web page that lists these institutions and celebrates their exceptional efforts to protect infants from perinatal hepatitis B transmission.
Related Immunize.org Resources
* Give Birth to the End of Hep B ([link removed]) main page
* Fact sheet: Do You Qualify for the Hepatitis B Birth Dose Honor Roll? If So, Apply Today. ([link removed])
* Handout on Immunize.org’s campaign: Give Birth to the End of Hep B ([link removed])
* Hepatitis B Birth Dose Honor Roll ([link removed]) web page
------------------------------------------------------------
Spotlight: Immunize.org resources focused on vaccine-preventable diseases, one disease at a time
Immunize.org offers a host of materials that focus on specific vaccine-preventable diseases. Here are some highlights.
Vaccines ([link removed]) main page leads viewers to 24 pages, one for each vaccine-preventable disease. These pages provide curated materials from public health authorities and Immunize.org on each disease and vaccine.
Ask the Experts ([link removed]) main page gives you access to more than 1,200 questions answered by Immunize.org experts. Topics include specific diseases and their vaccines as well as vaccine delivery guidance (e.g., administration, billing, documenting).
Advisory Committee on Immunization Practices (ACIP) ([link removed]) main page links to all current ACIP vaccine recommendations as well as most dating back to 1991. You can sort the ACIP recommendations by diseases or publication date.
Unprotected People Stories ([link removed]) main page features more than a hundred real-life accounts of people who suffered or died from vaccine-preventable diseases. There are compelling personal testimonies, remembrances, case reports, and newspaper articles.
Image Library ([link removed]) main page offers hundreds of photos of people affected by vaccine-preventable diseases; micrographs of viruses, bacteria, and pathology specimens; and pictures of people being vaccinated. Please follow noted copyright requirements.
------------------------------------------------------------
Vaccines in the news
These recent articles convey the potential risks of vaccine-preventable diseases and the importance of vaccination.
* STAT: We’ll Soon Have Tools to Protect Infants against RSV. Can We Put Them to Good Use? ([link removed]) (5/24/23)
* Science: COVID-19 Vaccines May Undergo Major Overhaul This Fall ([link removed]) (5/23/23)
* STAT: FDA Advisory Panel Backs Pfizer’s RSV Vaccine, but Expresses Some Safety Concerns ([link removed]) (5/18/23)
------------------------------------------------------------
Immunize.org Pages and Handouts
------------------------------------------------------------
Immunize.org updates the standing orders template for administering inactivated poliovirus vaccine to infants and children
Many healthcare facilities simplify vaccination by using standing orders. Immunize.org recently reviewed and updated its Standing Orders for Administering Inactivated Poliovirus Vaccine [IPV] to Infants and Children ([link removed]). A note was removed stating that young adults who received four doses of IPV before August 2009 were exempted from the recommendation for that one dose be administered after the fourth birthday. CDC no longer advises this exemption. Such individuals may receive an additional dose when identified, although no specific catch-up initiative is recommended. In addition, a QR code now links to the online version of the document.
Related Links
* Immunize.org: Standing Orders Templates for Administering Vaccines ([link removed]) main page
* Immunize.org: Handouts for Patients and Staff ([link removed]) main page, where you can sort materials by topic, vaccine, or language
* Immunize.org: Educational Materials for Patients and Staff ([link removed]) —an alphabetical listing of more than 230 ready-to-print staff educational materials and patient handouts
------------------------------------------------------------
Immunize.org posts corrected Simplified Chinese translation of “After the Shots . . . What to Do If Your Child Has Discomfort”
Immunize.org posted the corrected Simplified Chinese translation of its popular handout, After the Shots . . . What to Do If Your Child Has Discomfort ([link removed]). As noted previously, those who downloaded the Chinese version dated 3/29/2023 should discard it and replace it with the 5/15/2023 translation of the English 3/29/2023 version.
Related Link
* Immunize.org: Handouts: Chinese Translations ([link removed]) main page
------------------------------------------------------------
Immunize.org refreshes several popular handouts; make sure you use the latest versions
Immunize.org refreshed several of its popular handouts with minor edits. The following handouts were reviewed and updated:
* MMR Vaccine Does Not Cause Autism ([link removed])
* Using Standing Orders for Administering Vaccines: What You Should Know ([link removed])
* Suggestions to Improve Your Immunization Services ([link removed])
------------------------------------------------------------
Featured Resources
------------------------------------------------------------
CHOP releases new video that addresses treating fevers; check out the “Healthy at Home with Dr. Handy” playlist
In her latest video ([link removed]), Dr. Lori Handy, Associate Director of the Vaccine Education Center at Children’s Hospital of Philadelphia (CHOP) and board-certified infectious diseases pediatrician, discusses how to treat fevers, when they can become a problem, and what to do about fevers associated with vaccination.
Other recent videos include a discussion of ([link removed]) why vaccines don’t weaken a baby’s immune system ([link removed]) and how to keep newborns healthy ([link removed]).
Related Links
* CHOP: Dr. Handy's Corner ([link removed]) playlist
* CHOP: Videos and DVDs ([link removed])
------------------------------------------------------------
Notable Publications
------------------------------------------------------------
"COVID-19 Booster Vaccination in Early Pregnancy and Surveillance for Spontaneous Abortion" published in JAMA Network Open
In the May 19 issue, JAMA Network Open published COVID-19 Booster Vaccination in Early Pregnancy and Surveillance for Spontaneous Abortion ([link removed]). A portion of the conclusions and relevance section appears below.
In this case-control surveillance study, COVID-19 booster vaccination in pregnancy was not associated with spontaneous abortion. These findings support the safety of recommendations for COVID-19 booster vaccination, including in pregnant populations.
------------------------------------------------------------
"Evaluation of Waning of SARS-CoV-2 Vaccine–Induced Immunity: A Systematic Review and Meta-Analysis" published in JAMA Network Open
In the May 3 issue, JAMA Network Open published Evaluation of Waning of SARS-CoV-2 Vaccine–Induced Immunity: A Systematic Review and Meta-Analysis ([link removed]). A portion of the conclusions and relevance section appears below.
These findings suggest that the effectiveness of COVID-19 vaccines against laboratory-confirmed Omicron or Delta infection and symptomatic disease rapidly wanes over time after the primary vaccination cycle and booster dose. These results can inform the design of appropriate targets and timing for future vaccination programs.
------------------------------------------------------------
"Estimated U.S. Pediatric Hospitalizations and School Absenteeism Associated with Accelerated COVID-19 Bivalent Booster Vaccination" published in JAMA Network Open
In the May 19 issue, JAMA Network Open published Estimated U.S. Pediatric Hospitalizations and School Absenteeism Associated with Accelerated COVID-19 Bivalent Booster Vaccination ([link removed]). A portion of the conclusions and relevance section appears below.
In this decision analytical model, increased uptake of bivalent booster vaccination among eligible age groups was associated with decreased hospitalizations and school absenteeism in the pediatric population. These findings suggest that although COVID-19 prevention strategies often focus on older populations, the benefits of booster campaigns for children may be substantial.
------------------------------------------------------------
Upcoming Events
------------------------------------------------------------
Virtual: Immunization Coalition of Los Angeles hosts Summer Vaccine Film Forum on June 20
The Immunization Coalition of Los Angeles will host a Summer Vaccine Film Forum, June 20, 12:00–3:00 p.m. (ET). The virtual forum will feature two award-winning films, "Shot In The Arm" and "Vaccinate Watts," to highlight two perspectives on the challenges brought on by the pandemic, including fighting disinformation, community engagement, and more.
Register to reserve a spot ([link removed]) for this free event!
------------------------------------------------------------
Virtual: Watch June 21–23 ACIP meeting. Topics include RSV, polio, influenza, pneumococcal, dengue, chikungunya, mpox, meningococcal, and COVID-19 vaccines.
CDC will convene an extended, 3-day meeting of the Advisory Committee on Immunization Practices ([link removed]) (ACIP), June 21–23. The ACIP will discuss vaccination recommendations for respiratory syncytial virus (RSV), polio, influenza, pneumococcal, dengue, chikungunya, mpox, meningococcal, and COVID-19 vaccines.
No registration is required to watch webcasts of live ACIP meetings or listen via telephone. Opportunities for public comment are described on the website.
View the agenda ([link removed]).
Related Links
* ACIP main page ([link removed]) for access to webcast, agendas
* ACIP: Meeting Information ([link removed]) for presentation slides, content from previous meetings, and information about future meetings
------------------------------------------------------------
For more upcoming events, visit our Calendar of Events ([link removed]).
Editorial Information
Editor-in-Chief
Kelly L. Moore, MD, MPH
Managing Editor
John D. Grabenstein, RPh, PhD
Associate Editor
Sharon G. Humiston, MD, MPH
Writer/Publication Coordinator
Taryn Chapman, MS
Courtnay Londo, MA
Style and Copy Editor
Marian Deegan, JD
Web Edition Managers
Arkady Shakhnovich
Jermaine Royes
Contributing Writer
Laurel H. Wood, MPA
Technical Reviewer
Kayla Ohlde
About IZ Express
Immunize.org welcomes redistribution of this issue of IZ Express or selected articles.
When you do so, please add a note that Immunize.org is the source of the material and provide a link to this issue ([link removed]).
IZ Express is supported in part by Grant No. 1NH23IP922654 from the National Center for Immunization and Respiratory Diseases, CDC. Its contents are solely the responsibility of Immunize.org and do not necessarily represent the official views of CDC.
IZ Express Disclaimer ([link removed])
ISSN: 2771-8085
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Issue 1,695: May 31, 2023
Top Stories
* Immunize.org updates its "Checklist of Current Versions of U.S. COVID-19 Vaccination Guidance and Clinic Support Tools” to include new bivalent mRNA vaccine standing orders for children and adults from CDC. New version dated May 29.
* "Potential for Recurrent Mpox Outbreaks in Gay, Bisexual, and Other Men Who Have Sex with Men—United States, 2023" published in MMWR
* "Urban and Rural Mpox Incidence among Persons Aged 15–64 Years—United States, May 10–December 31, 2022" published in MMWR
* "Estimates of Bivalent mRNA Vaccine Durability in Preventing COVID-19–Associated Hospitalization and Critical Illness among Adults with and without Immunocompromising Conditions—VISION Network, September 2022–April 2023" published in MMWR
* Pew Research Center finds that Americans’ mostly positive views on childhood vaccines remain
* Calling students in grades 6 through 12: 2023 Dr. Maurice R. Hilleman Essay Contest, sponsored by CHOP’s Vaccine Education Center, open for submissions
* Immunize.org’s Hepatitis B Birth Dose Honor Roll recognizes 578 institutions, including two new honorees
* Spotlight: Immunize.org resources focused on vaccine-preventable diseases, one disease at a time
* Vaccines in the news
Immunize.org Pages and Handouts
* Immunize.org updates the standing orders template for administering inactivated poliovirus vaccine to infants and children
* Immunize.org posts corrected Simplified Chinese translation of “After the Shots . . . What to Do If Your Child Has Discomfort”
* Immunize.org refreshes several popular handouts; make sure you use the latest versions
Featured Resources
* CHOP releases new video that addresses treating fevers; check out the “Healthy at Home with Dr. Handy” playlist
Notable Publications
* "COVID-19 Booster Vaccination in Early Pregnancy and Surveillance for Spontaneous Abortion" published in JAMA Network Open
* "Evaluation of Waning of SARS-CoV-2 Vaccine–Induced Immunity: A Systematic Review and Meta-Analysis" published in JAMA Network Open
* "Estimated U.S. Pediatric Hospitalizations and School Absenteeism Associated with Accelerated COVID-19 Bivalent Booster Vaccination" published in JAMA Network Open
Upcoming Events
* Virtual: Immunization Coalition of Los Angeles hosts Summer Vaccine Film Forum on June 20
* Virtual: Watch June 21–23 ACIP meeting. Topics include RSV, polio, influenza, pneumococcal, dengue, chikungunya, mpox, meningococcal, and COVID-19 vaccines.
------------------------------------------------------------
Top Stories
------------------------------------------------------------
Immunize.org updates its "Checklist of Current Versions of U.S. COVID-19 Vaccination Guidance and Clinic Support Tools” to include new bivalent mRNA vaccine standing orders for children and adults from CDC. New version dated May 29.
Immunize.org reviews and updates the Checklist of Current Versions of U.S. COVID-19 Vaccination Guidance and Clinic Support Tools ([link removed]) at least monthly, prominently indicating when it was last revised at the top of the page. The checklist was updated a third time in May because CDC released widely anticipated new standing orders templates reflecting the most current recommendations for use of bivalent mRNA vaccines in children and adults. Our checklist also reflects CDC’s new interim COVID-19 vaccination schedule for all ages.
All COVID-19 vaccination providers should review the checklist regularly and download the latest CDC schedule and standing order documents. The checklist is posted on Immunize.org's Vaccines: COVID-19 ([link removed]) main page to help practices stay up to date.
Related Links
* Immunize.org: Checklist of Current Versions of U.S. COVID-19 Vaccination Guidance and Clinic Support Tools ([link removed]) (PDF)
* Immunize.org: Vaccines: COVID-19 ([link removed]) main page
* Immunize.org: Ask the Experts: COVID-19 ([link removed]) web page
* CDC: Interim Clinical Considerations ([link removed]) main page summarizing use of COVID-19 vaccines in the United States
------------------------------------------------------------
"Potential for Recurrent Mpox Outbreaks in Gay, Bisexual, and Other Men Who Have Sex with Men—United States, 2023" published in MMWR
CDC published Potential for Recurrent Mpox Outbreaks in Gay, Bisexual, and Other Men Who Have Sex with Men—United States, 2023 ([link removed]) in the May 26 issue of MMWR ([link removed]). A portion of the summary appears below.
Monkeypox (mpox) has disproportionately affected gay, bisexual, and other men who have sex with men (MSM); the percentage of MSM with immunity due to vaccination or infection varies among jurisdictions. . . .
Mathematical modeling suggests that the risk for future outbreaks depends linearly on the level of immunity in the population at risk; cumulative incidence, on the other hand, has multiple thresholds [based on proportion of immune individuals]. More than 592,000 MSM live in jurisdictions with risk for mpox recurrences capable of sustained transmission if a cluster of infectious cases were reintroduced. . . .
Increasing vaccination coverage among MSM at risk and in jurisdictions with low immunity has the potential to reduce the risk for and potential size of future mpox outbreaks.
Access the MMWR article in HTML ([link removed]) or PDF ([link removed]) .
Related Link
* MMWR's main page ([link removed]) provides access to MMWR Weekly and its companion publications
------------------------------------------------------------
"Urban and Rural Mpox Incidence among Persons Aged 15–64 Years—United States, May 10–December 31, 2022" published in MMWR
CDC published Urban and Rural Mpox Incidence among Persons Aged 15–64 Years—United States, May 10–December 31, 2022 ([link removed]) in the May 26 issue of MMWR ([link removed]). A portion of the summary appears below.
Information on urbanicity of mpox cases during the 2022 outbreak is limited. . . .
During May–December 2022, U.S. mpox incidence was 13.5 per 100,000 persons peaking in August. Among cisgender men and cisgender women, incidence in rural areas was 4% and 11% of incidence in large central urban areas, respectively. Incidence among Black or African American and Hispanic or Latino persons was higher than among White persons. . . .
National mpox surveillance should be continued to ensure persons at risk for mpox get tested and treated. Prevention efforts should be focused on MSM in urban areas.
Access the MMWR article in HTML ([link removed]) or PDF ([link removed]) .
Related Link
* MMWR's main page ([link removed]) provides access to MMWR Weekly and its companion publications
------------------------------------------------------------
"Estimates of Bivalent mRNA Vaccine Durability in Preventing COVID-19–Associated Hospitalization and Critical Illness among Adults with and without Immunocompromising Conditions—VISION Network, September 2022–April 2023" published in MMWR
CDC published Estimates of Bivalent mRNA Vaccine Durability in Preventing COVID-19–Associated Hospitalization and Critical Illness among Adults with and without Immunocompromising Conditions—VISION Network, September 2022–April 2023 ([link removed]) in the May 26 issue of MMWR ([link removed]). A portion of the summary appears below.
Bivalent mRNA COVID-19 vaccines help provide protection against medically attended COVID-19–associated illness. However, the durability of this protection is uncertain. . . .
Among adults aged ≥18 years without immunocompromising conditions, bivalent booster vaccine effectiveness (VE) against COVID-19–associated hospitalization declined from 62% at 7–59 days postvaccination to 24% at 120–179 days compared with VE among unvaccinated adults. Among immunocompromised adults, lower bivalent booster VE was observed. However, bivalent booster VE was sustained against critical COVID-19–associated outcomes, including intensive care unit admission or death. . . .
Adults should stay up to date with recommended COVID-19 vaccines. Optional additional bivalent vaccine doses are available for older adults and persons with immunocompromising conditions.
Access the MMWR article in HTML ([link removed]) or PDF ([link removed]) .
Related Link
* MMWR's main page ([link removed]) provides access to MMWR Weekly and its companion publications
------------------------------------------------------------
Pew Research Center finds that Americans’ mostly positive views on childhood vaccines remain
According to a survey conducted by the Pew Research Center ([link removed]) in March 2023, Americans remain steadfast in their belief in the overall value of childhood vaccines. However, there are signs of some concern, particularly among parents of young children and mothers. While the last 4 years demonstrated no change in the large majority who say the benefits of childhood vaccination against measles, mumps, and rubella (MMR) outweigh the risks, there is a sizable gap between higher public confidence in childhood vaccines and lower confidence in COVID-19 vaccines.
Other key findings:
* Fewer than half of Americans rate their perception of COVID-19 vaccines’ health benefits as high, but the majority perceive the risk of side effects as at least medium
* Americans’ positive perception of MMR vaccine remains largely steady in the wake of debate over COVID-19 vaccines
* Politically partisan differences widened over the requirement for MMR vaccine in K-12 schools
* Parents whose children are less than age 18 years perceive slightly higher risks from MMR vaccines than other adults
* The majority of Americans perceive a positive societal impact from childhood vaccines, though about four-in-ten wonder if vaccines are all necessary
* Doctors are at least somewhat trusted as sources of information about the health effects of MMR vaccine
* Interviews with those concerned about MMR vaccine reveal desires to rely on multiple sources of information, ones they believe to have trustworthy motives
Read the full report: Americans’ Largely Positive Views of Childhood Vaccines Hold Steady ([link removed]) .
------------------------------------------------------------
Calling students in grades 6 through 12: 2023 Dr. Maurice R. Hilleman Essay Contest, sponsored by CHOP’s Vaccine Education Center, open for submissions
The Vaccine Makers Project ([link removed]), the classroom-based program of the Vaccine Education Center (VEC) at Children’s Hospital of Philadelphia, invites submissions for the 2023 Maurice R. Hilleman Essay Contest. Students in grades 6 through 12 in the United States and Canada are encouraged to learn about Dr. Hilleman’s life and accomplishments and submit a 500- to 600-word essay by June 9, 2023. This year's writing prompt is "Preparedness is an important component of science as demonstrated by Maurice Hilleman when he identified the 1957 influenza pandemic. How is preparedness critical in science today?"
Details and the entry form are available at HillemanFilm.com/contest ([link removed]). This year there will be six winners—three each from the United States and Canada. The winners will each receive $500, a certificate, and recognition at a virtual award event this fall. Please share this information with eligible students or with teachers who may be interested in sharing with their students.
Related Links
* The Vaccine Makers Project ([link removed]) website
* VEC: Hilleman Film ([link removed]) website
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Immunize.org’s Hepatitis B Birth Dose Honor Roll recognizes 578 institutions, including two new honorees
Immunize.org is pleased to welcome two new institutions into its Hepatitis B Birth Dose Honor Roll ([link removed]), for a total of 578 honorees. The birthing institutions are listed below with their reported hepatitis B birth dose coverage rates in parentheses.
* Reynolds Memorial Hospital, Glen Dale, WV (95%)
* UPMC Chautauqua, Jamestown, NY (90%)
Several institutions are being recognized for qualifying for an additional year:
* St. Joseph’s Hospital North, Lutz, FL (92%) (2 years)
* Union Hospital, Terre Haute, IN (100%) (5 years)
* Platte Valley Medical Center, Brighton, CO (90%) (7 years)
* Arkansas Valley Regional Medical Center, La Junta, CO (91%) (9 years)
* Perry County Memorial Hospital, Tell City, IN (91%) (11 years)
The Honor Roll includes 578 birthing institutions from 45 states, the District of Columbia, Puerto Rico, Guam, Saipan, and our U.S. military base in England.
[link removed]
The Honor Roll is a key part of Immunize.org’s initiative urging the nation’s hospitals to Give Birth to the End of Hep B ([link removed]). Hospitals and birthing centers are recognized for attaining high coverage for hepatitis B vaccine at birth and meeting additional criteria. To learn whether your organization qualifies and to access the application form, please see Hepatitis B Birth Dose Honor Roll online ([link removed]).
Honorees are awarded an 8.5" x 11" color certificate suitable for printing and framing and their acceptance is announced through Immunize.org’s social media channels and to IZ Express’s 54,000+ readers.
Please visit the Hepatitis B Birth Dose Honor Roll web page that lists these institutions and celebrates their exceptional efforts to protect infants from perinatal hepatitis B transmission.
Related Immunize.org Resources
* Give Birth to the End of Hep B ([link removed]) main page
* Fact sheet: Do You Qualify for the Hepatitis B Birth Dose Honor Roll? If So, Apply Today. ([link removed])
* Handout on Immunize.org’s campaign: Give Birth to the End of Hep B ([link removed])
* Hepatitis B Birth Dose Honor Roll ([link removed]) web page
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Spotlight: Immunize.org resources focused on vaccine-preventable diseases, one disease at a time
Immunize.org offers a host of materials that focus on specific vaccine-preventable diseases. Here are some highlights.
Vaccines ([link removed]) main page leads viewers to 24 pages, one for each vaccine-preventable disease. These pages provide curated materials from public health authorities and Immunize.org on each disease and vaccine.
Ask the Experts ([link removed]) main page gives you access to more than 1,200 questions answered by Immunize.org experts. Topics include specific diseases and their vaccines as well as vaccine delivery guidance (e.g., administration, billing, documenting).
Advisory Committee on Immunization Practices (ACIP) ([link removed]) main page links to all current ACIP vaccine recommendations as well as most dating back to 1991. You can sort the ACIP recommendations by diseases or publication date.
Unprotected People Stories ([link removed]) main page features more than a hundred real-life accounts of people who suffered or died from vaccine-preventable diseases. There are compelling personal testimonies, remembrances, case reports, and newspaper articles.
Image Library ([link removed]) main page offers hundreds of photos of people affected by vaccine-preventable diseases; micrographs of viruses, bacteria, and pathology specimens; and pictures of people being vaccinated. Please follow noted copyright requirements.
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Vaccines in the news
These recent articles convey the potential risks of vaccine-preventable diseases and the importance of vaccination.
* STAT: We’ll Soon Have Tools to Protect Infants against RSV. Can We Put Them to Good Use? ([link removed]) (5/24/23)
* Science: COVID-19 Vaccines May Undergo Major Overhaul This Fall ([link removed]) (5/23/23)
* STAT: FDA Advisory Panel Backs Pfizer’s RSV Vaccine, but Expresses Some Safety Concerns ([link removed]) (5/18/23)
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Immunize.org Pages and Handouts
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Immunize.org updates the standing orders template for administering inactivated poliovirus vaccine to infants and children
Many healthcare facilities simplify vaccination by using standing orders. Immunize.org recently reviewed and updated its Standing Orders for Administering Inactivated Poliovirus Vaccine [IPV] to Infants and Children ([link removed]). A note was removed stating that young adults who received four doses of IPV before August 2009 were exempted from the recommendation for that one dose be administered after the fourth birthday. CDC no longer advises this exemption. Such individuals may receive an additional dose when identified, although no specific catch-up initiative is recommended. In addition, a QR code now links to the online version of the document.
Related Links
* Immunize.org: Standing Orders Templates for Administering Vaccines ([link removed]) main page
* Immunize.org: Handouts for Patients and Staff ([link removed]) main page, where you can sort materials by topic, vaccine, or language
* Immunize.org: Educational Materials for Patients and Staff ([link removed]) —an alphabetical listing of more than 230 ready-to-print staff educational materials and patient handouts
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Immunize.org posts corrected Simplified Chinese translation of “After the Shots . . . What to Do If Your Child Has Discomfort”
Immunize.org posted the corrected Simplified Chinese translation of its popular handout, After the Shots . . . What to Do If Your Child Has Discomfort ([link removed]). As noted previously, those who downloaded the Chinese version dated 3/29/2023 should discard it and replace it with the 5/15/2023 translation of the English 3/29/2023 version.
Related Link
* Immunize.org: Handouts: Chinese Translations ([link removed]) main page
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Immunize.org refreshes several popular handouts; make sure you use the latest versions
Immunize.org refreshed several of its popular handouts with minor edits. The following handouts were reviewed and updated:
* MMR Vaccine Does Not Cause Autism ([link removed])
* Using Standing Orders for Administering Vaccines: What You Should Know ([link removed])
* Suggestions to Improve Your Immunization Services ([link removed])
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Featured Resources
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CHOP releases new video that addresses treating fevers; check out the “Healthy at Home with Dr. Handy” playlist
In her latest video ([link removed]), Dr. Lori Handy, Associate Director of the Vaccine Education Center at Children’s Hospital of Philadelphia (CHOP) and board-certified infectious diseases pediatrician, discusses how to treat fevers, when they can become a problem, and what to do about fevers associated with vaccination.
Other recent videos include a discussion of ([link removed]) why vaccines don’t weaken a baby’s immune system ([link removed]) and how to keep newborns healthy ([link removed]).
Related Links
* CHOP: Dr. Handy's Corner ([link removed]) playlist
* CHOP: Videos and DVDs ([link removed])
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Notable Publications
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"COVID-19 Booster Vaccination in Early Pregnancy and Surveillance for Spontaneous Abortion" published in JAMA Network Open
In the May 19 issue, JAMA Network Open published COVID-19 Booster Vaccination in Early Pregnancy and Surveillance for Spontaneous Abortion ([link removed]). A portion of the conclusions and relevance section appears below.
In this case-control surveillance study, COVID-19 booster vaccination in pregnancy was not associated with spontaneous abortion. These findings support the safety of recommendations for COVID-19 booster vaccination, including in pregnant populations.
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"Evaluation of Waning of SARS-CoV-2 Vaccine–Induced Immunity: A Systematic Review and Meta-Analysis" published in JAMA Network Open
In the May 3 issue, JAMA Network Open published Evaluation of Waning of SARS-CoV-2 Vaccine–Induced Immunity: A Systematic Review and Meta-Analysis ([link removed]). A portion of the conclusions and relevance section appears below.
These findings suggest that the effectiveness of COVID-19 vaccines against laboratory-confirmed Omicron or Delta infection and symptomatic disease rapidly wanes over time after the primary vaccination cycle and booster dose. These results can inform the design of appropriate targets and timing for future vaccination programs.
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"Estimated U.S. Pediatric Hospitalizations and School Absenteeism Associated with Accelerated COVID-19 Bivalent Booster Vaccination" published in JAMA Network Open
In the May 19 issue, JAMA Network Open published Estimated U.S. Pediatric Hospitalizations and School Absenteeism Associated with Accelerated COVID-19 Bivalent Booster Vaccination ([link removed]). A portion of the conclusions and relevance section appears below.
In this decision analytical model, increased uptake of bivalent booster vaccination among eligible age groups was associated with decreased hospitalizations and school absenteeism in the pediatric population. These findings suggest that although COVID-19 prevention strategies often focus on older populations, the benefits of booster campaigns for children may be substantial.
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Upcoming Events
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Virtual: Immunization Coalition of Los Angeles hosts Summer Vaccine Film Forum on June 20
The Immunization Coalition of Los Angeles will host a Summer Vaccine Film Forum, June 20, 12:00–3:00 p.m. (ET). The virtual forum will feature two award-winning films, "Shot In The Arm" and "Vaccinate Watts," to highlight two perspectives on the challenges brought on by the pandemic, including fighting disinformation, community engagement, and more.
Register to reserve a spot ([link removed]) for this free event!
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Virtual: Watch June 21–23 ACIP meeting. Topics include RSV, polio, influenza, pneumococcal, dengue, chikungunya, mpox, meningococcal, and COVID-19 vaccines.
CDC will convene an extended, 3-day meeting of the Advisory Committee on Immunization Practices ([link removed]) (ACIP), June 21–23. The ACIP will discuss vaccination recommendations for respiratory syncytial virus (RSV), polio, influenza, pneumococcal, dengue, chikungunya, mpox, meningococcal, and COVID-19 vaccines.
No registration is required to watch webcasts of live ACIP meetings or listen via telephone. Opportunities for public comment are described on the website.
View the agenda ([link removed]).
Related Links
* ACIP main page ([link removed]) for access to webcast, agendas
* ACIP: Meeting Information ([link removed]) for presentation slides, content from previous meetings, and information about future meetings
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For more upcoming events, visit our Calendar of Events ([link removed]).
Editorial Information
Editor-in-Chief
Kelly L. Moore, MD, MPH
Managing Editor
John D. Grabenstein, RPh, PhD
Associate Editor
Sharon G. Humiston, MD, MPH
Writer/Publication Coordinator
Taryn Chapman, MS
Courtnay Londo, MA
Style and Copy Editor
Marian Deegan, JD
Web Edition Managers
Arkady Shakhnovich
Jermaine Royes
Contributing Writer
Laurel H. Wood, MPA
Technical Reviewer
Kayla Ohlde
About IZ Express
Immunize.org welcomes redistribution of this issue of IZ Express or selected articles.
When you do so, please add a note that Immunize.org is the source of the material and provide a link to this issue ([link removed]).
IZ Express is supported in part by Grant No. 1NH23IP922654 from the National Center for Immunization and Respiratory Diseases, CDC. Its contents are solely the responsibility of Immunize.org and do not necessarily represent the official views of CDC.
IZ Express Disclaimer ([link removed])
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