From Immunize.org <[email protected]>
Subject IZ Express #1,688: Mpox in MMWR, ACIP meeting, and more
Date April 19, 2023 10:45 AM
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Issue 1,688: April 19, 2023

Top Stories
* “Racial and Ethnic Disparities in Mpox Cases and Vaccination among Adult Males—United States, May–December 2022” published in MMWR
* “Epidemiologic and Clinical Features of Mpox-Associated Deaths—United States, May 10, 2022–March 7, 2023” published in MMWR
* Virtual: Watch April 19 ACIP meeting. Topics include updates to COVID-19 vaccine recommendations.
* National Infant Immunization Week is April 24–30; use CDC’s digital media toolkit
* Spotlight: Immunize.org resources to help with your vaccine advocacy
* Vaccines in the news


Immunize​.org Pages and Handouts
* Immunize.org updates its resource “Pneumococcus: Questions and Answers”
* Immunize.org updates its resource for healthcare professionals: “Don't Be Guilty of These Preventable Errors in Vaccine Storage and Handling!”


Featured Resources
* Immunize.org updates and streamlines its “Vaccines: COVID-19” main page
* Organizing a new vaccination program? Use Immunize.org’s Vaccinating Adults: A Step-by-Step Guide—free to download by chapter or in its entirety.


Notable Publications
* "COVID-19 Vaccines in Young Children—Reassuring Evidence for Parents," commentary by Paul Offit, MD, published in JAMA Pediatrics
* "Bivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants" published in New England Journal of Medicine


Global News
* “Update on Wild Poliovirus Type 1 Outbreak—Southeastern Africa, 2021–2022” published in MMWR

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Top Stories
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“Racial and Ethnic Disparities in Mpox Cases and Vaccination among Adult Males—United States, May–December 2022” published in MMWR

CDC published Racial and Ethnic Disparities in Mpox Cases and Vaccination among Adult Males—United States, May–December 2022 ([link removed]) on April 14 in MMWR ([link removed]). A portion of the article appears below.

During May 10–December 31, 2022, mpox case incidences were higher among racial and ethnic minority males than those among White males, except Asian males, whose incidence was similar to that among White males. Disparities in mpox incidence peaked in August, particularly among Black (RR = 6.9) and Hispanic (RR = 4.1) males, relative to White males. After incidence peaked in August, disparities decreased slightly through December; however, substantial disparities in incidence remained during October–December. . . .

The vaccination-to-case ratio aggregated across all racial and ethnic groups during the full analytic period was 23.8. The highest vaccination-to-case ratios were observed among Asian (59.2) and White (42.5) males, whereas those among Hispanic and Black males were the lowest (16.2 and 8.8, respectively). From the beginning of the outbreak (May–June) to its peak (August), all groups showed increases in vaccination-to-case ratios, reflecting higher vaccination availability during this period. However, across each separate period examined, vaccination-to-case ratios were lowest among Black and Hispanic males (Figure).

Sustained equity-based strategies, such as tailored messaging and expanding vaccination services to reach racial and ethnic minority groups, are needed to prevent disparities in future mpox outbreaks.

Access the MMWR article in HTML ([link removed]) or PDF ([link removed]).

Related Link
* MMWR's main page ([link removed]) provides access to MMWR Weekly and its companion publications

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“Epidemiologic and Clinical Features of Mpox-Associated Deaths—United States, May 10, 2022–March 7, 2023” published in MMWR

CDC published Epidemiologic and Clinical Features of Mpox-Associated Deaths—United States, May 10, 2022–March 7, 2023 ([link removed]) on April 14 in MMWR ([link removed]). A portion of the summary appears below.

Thirty-eight mpox-associated deaths occurred in the United States during May 10, 2022–March 7, 2023 (1.3 mpox-associated deaths per 1,000 cases). Most decedents were non-Hispanic Black or African American (87%) persons and cisgender men (95%). Among 24 decedents with HIV for whom data were available, all had advanced HIV, typically with a CD4 count <50. . . .

Equitable and early access to prevention and treatment for both mpox and HIV is critical to reducing mpox-related mortality.

Access the MMWR article in HTML ([link removed]) or PDF ([link removed]).

Related Link
* MMWR's main page ([link removed]) provides access to MMWR Weekly and its companion publications

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Virtual: Watch April 19 ACIP meeting. Topics include updates to COVID-19 vaccine recommendations.

CDC will convene its Advisory Committee on Immunization Practices ([link removed]) (ACIP) today, April 19, 11:00 a.m.–3:00 p.m. (ET). The meeting will include discussion of the use of bivalent COVID-19 mRNA vaccines as primary series vaccines, consideration of an additional booster dose recommendation among people at high risk of serious COVID-19 illness, and simplification of the COVID-19 vaccination schedule.

No registration is required to watch webcasts of live ACIP meetings or listen via telephone. Opportunities for public comment are described on the website.

Related Links
* ACIP main page ([link removed]) for access to webcast, agendas
* ACIP: Meeting Information ([link removed]) for presentation slides, content from previous meetings, and information about future meetings

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National Infant Immunization Week is April 24–30; use CDC’s digital media toolkit

National Infant Immunization Week ([link removed]) (NIIW), April 24–30, highlights the importance of protecting infants from vaccine-preventable diseases and celebrates the achievements of immunization partners. Completing the recommended vaccinations by age 2 years is the best way to protect young children from 15 potentially life-threatening diseases. After the disruptions of three pandemic years, these messages are more important than ever for families to hear.

CDC makes it simple for you to participate in NIIW by using their 2023 NIIW Digital Media Toolkit ([link removed]) to plan activities. The toolkit includes updated English and Spanish logos, sample social media content, social graphics, and key messages. Please share your posts using the hashtag #ivax2protect.

Related Links
* CDC: National Infant Immunization Week ([link removed]) main page
* CDC: 2023 NIIW Digital Media Toolkit ([link removed]) main page
* Immunize.org: Parent Handouts ([link removed]) main page

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Spotlight: Immunize.org resources to help with your vaccine advocacy

In this week’s Spotlight, we summarize resources at Immunize.org that can aid your vaccine advocacy efforts.

State Laws and Mandates by Vaccine ([link removed]) main page contains links to vaccine-specific requirements state by state for daycare, K-12, and post-secondary education settings. State-specific information about exemption policies is available as well.

State Exemptions ([link removed]) main page offers information on state mandates by vaccine-preventable disease. It includes policy statements from medical organizations endorsing strong school and childcare vaccination requirements and the elimination of non-medical exemptions.

State Information: Exemptions Permitted for State Immunization Requirements ([link removed]) web page shows which states allow medical, religious, and personal vaccination exemptions and offers a map of exemptions permitted for school and child care.

State Information: Direct Links to State Immunization Websites ([link removed]) main page offers links to each state’s vaccination policy web page.

Talking about Vaccines ([link removed]) main page provides medical professionals with background information and practical resources divided into different topics that will help them discuss vaccination with concerned parents or patients.

Unprotected People Stories ([link removed]) main page features 109 real-life accounts of people who suffered or died from vaccine-preventable diseases: compelling personal testimonies, remembrances, case reports, and newspaper articles.

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Vaccines in the news

These recent articles convey the potential risks of vaccine-preventable diseases and the importance of vaccination.

* Medpage Today: Vaccine Mandates Are Not Enough to Solve Our Infectious Disease Problem ([link removed]) (4/11/23)

* USA Today:[link removed] House to Invest $5 Billion in Next-Generation COVID Vaccines. Here’s Why We Need New Ones. ([link removed]) (4/10/23)

* NBC News: Conspiracy Theorists Made Tiffany Dover into an Anti-vaccine Icon. She’s Finally Ready to Talk about It. ([link removed]) (4/10/23)

* ABC: Florida Officials Cut Key Data From Vaccine Study ([link removed]) (4/8/23)

* Contemporary Pediatrics: Half of Meningococcal Vaccination Appointments Delayed or Canceled during COVID-19 Pandemic ([link removed]) (4/5/23)

* Wall Street Journal: My Family and the Measles Vaccine ([link removed]) (3/23/23)

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Immunize​.org Pages and Handouts
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Immunize.org updates its resource “Pneumococcus: Questions and Answers”

Immunize​.org updated its resource Pneumococcus: Questions and Answers ([link removed]) to incorporate the newer pneumococcal conjugate vaccines (PCV15 and PCV20) and their recommendations.

Related Links
* Immunize​.org: Handouts: Q&As: Diseases and Vaccines ([link removed]) web page
* Immunize​.org: Handouts: Pneumococcal conjugate (PCV) ([link removed]) web page
* Immunize​.org: Handouts: Pneumococcal polysaccharide (PPSV) ([link removed]) web page
* Immunize​.org: Handouts for Patients and Staff ([link removed]) web page, where you can sort materials by topic, vaccine, or language
* Immunize​.org: Educational Materials for Patients and Staff ([link removed])—an alphabetical listing of more than 300 ready-to-print staff educational materials and patient handouts

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Immunize.org updates its resource for healthcare professionals: “Don't Be Guilty of These Preventable Errors in Vaccine Storage and Handling!”

Immunize​.org recently updated its resource for healthcare professionals: Don't Be Guilty of These Preventable Errors in Vaccine Administration! ([link removed]) Changes include information on accessing CDC's vaccine storage and handling information for COVID-19 vaccines.

Related Links
* Immunize​.org: Ask the Experts: Administering Vaccines ([link removed]) web page
* Immunize​.org: Clinic Tools: Administering Vaccines ([link removed]) web page
* Immunize​.org: Handouts: Administering Vaccines ([link removed]) web page
* Immunize​.org: Handouts for Patients and Staff ([link removed]) web page, where you can sort materials by topic, vaccine, or language
* Immunize​.org: Educational Materials for Patients and Staff ([link removed])—an alphabetical listing of more than 300 ready-to-print staff educational materials and patient handouts

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Featured Resources
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Immunize.org updates and streamlines its “Vaccines: COVID-19” main page

Immunize.org updated and simplified its Vaccines: COVID-19 ([link removed]) main page. This page directs visitors seeking quick links to any print-ready federal fact sheets and COVID-19 vaccination resource to Immunize.org’s Checklist of Current Versions of U.S. COVID-19 Vaccination Guidance and Clinic Support Tools ([link removed]). This checklist consolidates all of these resources in one document, and is updated at least monthly.

Bookmark Immunize.org's Vaccines: COVID-19 ([link removed]) main page to connect with a comprehensive list of resources from CDC and FDA including fact sheets, clinical considerations, vaccine administration tools, and storage and handling guidance.

Related Links
* Immunize.org: Checklist of Current Versions of U.S. COVID-19 Vaccination Guidance and Clinic Support Tools ([link removed])(PDF)
* Immunize.org: Vaccines: COVID-19 ([link removed]) main page
* Immunize.org: Ask the Experts: COVID-19 ([link removed]) web page
* CDC: Interim Clinical Considerations ([link removed]) main page summarizing use of COVID-19 vaccines in the United States

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Organizing a new vaccination program? Use Immunize​.org’s Vaccinating Adults: A Step-by-Step Guide—free to download by chapter or in its entirety.

Download Immunize​.org’s free 142-page book on adult vaccination to help build your program and train your team: Vaccinating Adults: A Step-by-Step Guide (Guide) ([link removed]).

This thorough "how to" guide on adult vaccination provides easy-to-use, practical information covering all essential activities. It helps vaccine providers enhance their existing adult vaccination services or introduce them into any clinical setting.

The Guide is available to download/print either by chapter or in its entirety free at www.immunize.org/guide ([link removed]). The National Vaccine Program Office and CDC both supported the development of the Guide and provided early technical review.

The Guide is a valuable resource to assist providers in increasing adult vaccination rates. Be sure to get a copy today!

Please note: this guide was produced in 2017, before the COVID-19 era, and reflects the recommendations of that time.

Related Links
* Vaccinating Adults: A Step-by-Step Guide ([link removed]) main page, permitting download of entire Guide (142 pages, PDF) ([link removed])
* View the table of contents and individual chapters (PDF):
+ Table of Contents ([link removed])
+ Step 1: Getting Started ([link removed])
+ Step 2: Setting Up for Vaccination Services ([link removed])
+ Step 3: Vaccine Storage and Handling ([link removed])
+ Step 4: Deciding Whom to Vaccinate ([link removed])
+ Step 5: Administering Vaccines ([link removed])
+ Step 6: Documentation and Related Issues ([link removed])
+ Step 7A: Financial Considerations ([link removed])
+ Step 7B: How to Bill for Adult Immunizations ([link removed])
* Immunize​.org’s educational materials (handouts) on adult immunization ([link removed])

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Notable Publications
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"COVID-19 Vaccines in Young Children—Reassuring Evidence for Parents," commentary by Paul Offit, MD, published in JAMA Pediatrics

In the January 23 issue, JAMA Pediatrics published a commentary by Paul Offit, MD, titled COVID-19 Vaccines in Young Children—Reassuring Evidence for Parents ([link removed]). A portion of the article appears below.

Parents should be both compelled and reassured by the following facts: (1) although the COVID-19 pandemic is ending, SARS-CoV2 virus will be circulating for years, if not decades; (2) while some SARS-CoV-2 variants might have become less virulent, the virus is unlikely to evolve to avirulence; (3) about 3 to 4 million children will be born every year who will be susceptible to this virus; (4) the SARS-CoV-2 virus can cause severe and occasionally fatal disease in all age groups; (5) mRNA vaccines, which have now been given to more than 10 million children between 5 and 11 years of age, have been shown to be effective at preventing severe disease; and (6) myocarditis is an extremely rare consequence of mRNA vaccines in young children. Given the amount of information currently available to parents, the decision to vaccinate their children should be an easy one.

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"Bivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants" published in New England Journal of Medicine

In the April 5 issue, New England Journal of Medicine published Bivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants ([link removed]). The study found a vaccine efficacy of 81.8% for medically attended severe lower respiratory tract illness occurring within 90 days after birth, and 69.7% within 180 days after birth. The conclusions section appears below.

RSVpreF vaccine administered during pregnancy was effective against medically attended severe RSV-associated lower respiratory tract illness in infants, and no safety concerns were identified.

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Global News
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“Update on Wild Poliovirus Type 1 Outbreak—Southeastern Africa, 2021–2022” published in MMWR

CDC published Update on Wild Poliovirus Type 1 Outbreak—Southeastern Africa, 2021–2022 ([link removed]) on April 14 in MMWR ([link removed]). A portion of the summary appears below.

To date, one WPV1 [wild poliovirus type 1] case was detected in Malawi and eight in Mozambique. These countries and Tanzania, Zambia, and Zimbabwe implemented up to six national and subnational supplementary immunization activities (SIAs) per country and strengthened poliovirus surveillance. . . .

Further enhancing surveillance, implementing high-quality SIAs, and strengthening routine immunization are essential to stopping WPV1 transmission within 12 months of the first case, thereby preserving the WHO African Region’s WPV-free status.

Access the MMWR article in HTML ([link removed]) or PDF ([link removed]).

Related Link
* MMWR's main page ([link removed]) provides access to MMWR Weekly and its companion publications

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For more upcoming events, visit our Calendar of Events ([link removed]).

Editorial Information

Editor-in-Chief
Kelly L. Moore, MD, MPH

Managing Editor
John D. Grabenstein, RPh, PhD

Associate Editor
Sharon G. Humiston, MD, MPH

Writer/Publication Coordinator
Taryn Chapman, MS
Courtnay Londo, MA

Style and Copy Editor
Marian Deegan, JD

Web Edition Managers
Arkady Shakhnovich
Jermaine Royes

Contributing Writer
Laurel H. Wood, MPA

Technical Reviewer
Kayla Ohlde

About IZ Express
Immunize​.org welcomes redistribution of this issue of IZ Express or selected articles. When you do so, please add a note that Immunize​.org is the source of the material and provide a link to this issue ([link removed]).

IZ Express is supported in part by Grant No. 1NH23IP922654 from the National Center for Immunization and Respiratory Diseases, CDC. Its contents are solely the responsibility of Immunize​.org and do not necessarily represent the official views of CDC.

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